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Hepatocellular Cancer: Pathologic Considerations

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Abstract

While the incidence of HCCs has been rising worldwide, there has been a steady stream of novel information related to the histologic characteristics of HCCs, including their pattern of spread, the risk factors for recurrence, and long-term prognosis. More particularly, a focus of great interest has been the diagnosis of early HCC. Understanding by histopathologists, surgeons, hepatologists, and oncologists of the nuances of the diagnosis of early HCC, as well as the importance of detailed pathologic analysis of surgical specimens, is crucial to developing appropriate therapeutic algorithms based on precise prognostic stratification.

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References

  1. Nzeako UC, Goodman ZD, Ishak KG (1996) Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients. Am J Clin Pathol 105:65–75

    CAS  Google Scholar 

  2. Smalley SR, Moertel CG, Hilton JF, Weiland LH, Weiand HS, Adson MA, Melton LJ, 3rd, Batts K (1988) Hepatoma in the noncirrhotic liver. Cancer 62:1414–1424

    Article  CAS  PubMed  Google Scholar 

  3. Bismuth H, Chiche L, Castaing D (1995) Surgical treatment of hepatocellular carcinomas in noncirrhotic liver: experience with 68 liver resections. World J Surg 19:35–41

    Article  CAS  PubMed  Google Scholar 

  4. Kishi K, Shikata T, Hirohashi S, Hasegawa H, Yamazaki S, Makuuchi M (1983) Hepatocellular carcinoma. A clinical and pathologic analysis of 57 hepatectomy cases. Cancer 51:542–548

    Article  CAS  PubMed  Google Scholar 

  5. Lauwers GY, Vauthey JN (1998) Pathological aspects of hepatocellular carcinoma: a critical review of prognostic factors. Hepatogastroenterology 45(Suppl 3):1197–1202

    PubMed  Google Scholar 

  6. Yuki K, Hirohashi S, Sakamoto M, Kanai T, Shimosato Y (1990) Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases. Cancer 66: 2174–2179

    Article  CAS  PubMed  Google Scholar 

  7. Adachi E, Maeda T, Matsumata T, Shirabe K, Kinukawa N, Sugimachi K, Tsuneyoshi M (1995) Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 108:768–775

    Article  CAS  PubMed  Google Scholar 

  8. Liver Cancer Study Group of Japan (1990) Primary liver cancer in Japan. Clinicopathologic features and results of surgical treatment. Ann Surg 211:277–287

    Google Scholar 

  9. Izumi R, Shimizu K, Ii T, Yagi M, Matsui O, Nonomura A, Miyazaki I (1994) Prognostic factors of hepatocellular carcinoma in patients undergoing hepatic resection. Gastroenterology 106:720–727

    CAS  PubMed  Google Scholar 

  10. Liver Cancer Study Group of Japan (1997) Classification of primary liver cancer. Kanehira & Co., Tokyo, p. 30 (in English)

    Google Scholar 

  11. Nagao T, Inoue S, Goto S, Mizuta T, Omori Y, Kawano N, Morioka Y (1987) Hepatic resection for hepatocellular carcinoma. Clinical features and long-term prognosis. Ann Surg 205:33–40

    Article  CAS  PubMed  Google Scholar 

  12. Arii S, Tanaka J, Yamazoe Y, Minematsu S, Morino T, Fujita K, Maetani S, Tobe T (1992) Predictive factors for intrahepatic recurrence of hepatocellular carcinoma after partial hepatectomy. Cancer 69:913–919

    Article  CAS  PubMed  Google Scholar 

  13. Eggel H (1901) Uber das primare carcinom der leber. Beitr Pathol Ann 30:506–604

    Google Scholar 

  14. Nagao T, Inoue S, Yoshimi F, Sodeyama M, Omori Y, Mizuta T, Kawano N, Morioka Y (1990) Postoperative recurrence of hepatocellular carcinoma. Ann Surg 211:28–33

    Article  CAS  PubMed  Google Scholar 

  15. Lai EC, You K-T, Ng IO, Shek TW (1993) The pathological basis of resection margin for hepatocellular carcinoma. World J Surg 17:786–791

    Article  CAS  PubMed  Google Scholar 

  16. Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama T, Kawasaki S, Makuuchi M (2003) Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 38:200–207

    Article  PubMed  Google Scholar 

  17. Lauwers GY, Terris B, Balis UJ, Batts KP, Regimbeau JM, Chang Y, Graeme-Cook F, Yamabe H, Ikai I, Cleary KR, Fujita S, Flejou JF, Zukerberg LR, Nagorney DM, Belghiti J, Yamaoka Y, Vauthey JN (2002) Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index. Am J Surg Pathol 26:25–34

    Article  PubMed  Google Scholar 

  18. Sakamoto M, Hirohashi S, Tsuda H, Shimosato Y, Makuuchi M, Hosoda Y (1989) Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern. Am J Surg Pathol 13:1064–1067

    Article  CAS  PubMed  Google Scholar 

  19. Toyosaka A, Okamoto E, Mitsunobu M, Oriyama T, Nakao N, Miura K (1996) Pathologic and radiographic studies of intrahepatic metastasis in hepatocellular carcinoma; the role of efferent vessels. HPB Surgery 10:97–104

    Article  CAS  PubMed  Google Scholar 

  20. Ikai I, Yamaoka Y, Yamamoto Y, Ozaki N, Sakai Y, Satoh S, Shinkura N, Yamamoto M (1998) Surgical intervention for patients with stage IV-A hepatocellular carcinoma without lymph node metastasis: proposal as a standard therapy. Ann Surg 227: 433–439

    Article  CAS  PubMed  Google Scholar 

  21. Kojiro M, Sugihara S, Kakizoe S, Nakashima O, Kiyomatsu K (1989) Hepatocellular carcinoma with sarcomatous change: a special reference to the relationship with anticancer therapy. Cancer Chemother Pharmacol 23(Suppl):S4–S8

    Google Scholar 

  22. Kojiro M, Kawabata K, Kawano Y, Shirai F, Takemoto N, Nakashima T (1982) Hepatocellular carcinoma presenting as intrabile duct tumor growth: a clinicopathologic study of 24 cases. Cancer 49:2144–2147

    Article  CAS  PubMed  Google Scholar 

  23. Nakashima T, Kojiro M (1986) Pathologic characteristics of hepatocellular carcinoma. Semin Liver Dis 6:259–266

    Article  CAS  PubMed  Google Scholar 

  24. Ishak KG, Anthony PP, Sobin L (1994) Histological typing of tumours in the liver. Springer, Berlin

    Google Scholar 

  25. Denk H, Stumptner C, Fuchsbichler A, Muller T, Farr G, Muller W, Terracciano L, Zatloukal K (2006) Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related? J Pathol 208:653–661

    Article  CAS  PubMed  Google Scholar 

  26. Edmondson H, Steiner P (1954) Primary carcinoma of the liver; a study of 100 cases among 48,900 necropsies. Cancer 7:462–503

    Article  CAS  PubMed  Google Scholar 

  27. Haratake J, Takeda S, Kasai T, Nakano S, Tokui N (1993) Predictable factors for estimating prognosis of patients after resection of hepatocellular carcinoma. Cancer 72: 1178–1183

    Article  CAS  PubMed  Google Scholar 

  28. Adachi E, Maeda T, Kajiyama K, Kinukawa N, Matsumata T, Sugimachi K, Tsuneyoshi M (1996) Factors correlated with portal venous invasion by hepatocellular carcinoma: univariate and multivariate analyses of 232 resected cases without preoperative treatments. Cancer 77:2022–2031

    Article  CAS  PubMed  Google Scholar 

  29. Lai CL, Wu PC, Lam KC, Todd D (1979) Histologic prognostic indicators in hepatocellular carcinoma. Cancer 44:1677–1683

    Article  CAS  PubMed  Google Scholar 

  30. Yang SH, Watanabe J, Nakashima O, Kojiro M (1996) Clinicopathologic study on clear cell hepatocellular carcinoma. Pathol Int 46:503–509

    Article  CAS  PubMed  Google Scholar 

  31. Maeda T, Adachi E, Kajiyama K, Takenaka K, Sugimachi K, Tsuneyoshi M (1996) Spindle cell hepatocellular carcinoma. A clinicopathologic and immunohistochemical analysis of 15 cases. Cancer 77:51–57

    Article  CAS  PubMed  Google Scholar 

  32. Vauthey JN, Klimstra D, Franceschi D, Tao Y, Fortner J, Blumgart L, Brennan M (1995) Factors affecting long-term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg 169:28–34

    Article  CAS  PubMed  Google Scholar 

  33. Nigam A, Zhurak M, Boitnott J, Goodman S, Abrams R, Sitzmann J (1995) Factors affecting survival in Western patients following curative resection for hepatocellular carcinoma [abstract]. Gastroenterology 108:A1235

    Google Scholar 

  34. Esnaola NF, Lauwers GY, Mirza NQ, Nagorney DM, Doherty D, Ikai I, Yamaoka Y, Regimbeau JM, Belghiti J, Curley SA, Ellis LM, Vauthey JN (2002) Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg 6:224–232; discussion 32

    Article  PubMed  Google Scholar 

  35. Craig JR, Peters RL, Edmondson HA, Omata M (1980) Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer 46:372–379

    Article  CAS  PubMed  Google Scholar 

  36. Berman MA, Burnham JA, Sheahan DG (1988) Fibrolamellar carcinoma of the liver: an immunohistochemical study of nineteen cases and a review of the literature. Hum Pathol 19:784–794

    Article  CAS  PubMed  Google Scholar 

  37. El-Serag HB, Davila JA (2004) Is fibrolamellar carcinoma different from hepatocellular carcinoma? A US population-based study. Hepatology 39:798–803

    Article  PubMed  Google Scholar 

  38. Ringe B, Wittekind C, Weimann A, Tusch G, Pichlmayr R (1992) Results of hepatic resection and transplantation for fibrolamellar carcinoma. Surg Gynecol Obstet 175:299–305

    CAS  PubMed  Google Scholar 

  39. Soreide O, Czerniak A, Bradpiece H, Bloom S, Blumgart L (1986) Characteristics of fibrolamellar hepatocellular carcinoma. A study of nine cases and a review of the literature. Am J Surg 151:518–523

    Article  CAS  PubMed  Google Scholar 

  40. Stipa F, Yoon SS, Liau KH, Fong Y, Jarnagin WR, D’Angelica M, Abou-Alfa G, Blumgart LH, DeMatteo RP (2006) Outcome of patients with fibrolamellar hepatocellular carcinoma. Cancer 106:1331–1338

    Article  PubMed  Google Scholar 

  41. Kakar S, Burgart LJ, Batts KP, Garcia J, Jain D, Ferrell LD (2005) Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Mod Pathol 18:1417–1423

    Article  PubMed  Google Scholar 

  42. Kojiro M (1997) Pathology of hepatocellular carcinoma. Churchill Livingstone, New York

    Google Scholar 

  43. Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L (1985) Combined hepatocellular-cholangiocarcinoma. A histologic and immunohistochemical study. Cancer 55:124–135

    Article  CAS  PubMed  Google Scholar 

  44. Maeda T, Adachi E, Kajiyama K, Sugimachi K, Tsuneyoshi M (1995) Combined hepatocellular and cholangiocarcinoma: proposed criteria according to cytokeratin expression and analysis of clinicopathologic features. Hum Pathol 26:956–964

    Article  CAS  PubMed  Google Scholar 

  45. Morcos M, Dubois S, Bralet MP, Belghiti J, Degott C, Terris B (2001) Primary liver carcinoma in genetic hemochromatosis reveals a broad histologic spectrum. Am J Clin Pathol 116: 738–743

    Article  CAS  PubMed  Google Scholar 

  46. Nakamura S, Suzuki S, Sakaguchi T, Serizawa A, Konno H, Baba S, Baba S, Muro H (1996) Surgical treatment of patients with mixed hepatocellular carcinoma and cholangiocarcinoma. Cancer 78:1671–1676

    Article  CAS  PubMed  Google Scholar 

  47. Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, Tsui W, Ohta H, Nakanuma Y (2003) Hepatic ‘stem cell’ malignancies in adults: four cases. Histopathology 43:263–271

    Article  CAS  PubMed  Google Scholar 

  48. Tickoo SK, Zee SY, Obiekwe S, Xiao H, Koea J, Robiou C, Blumgart LH, Jarnagin W, Ladanyi M, Klimstra DS (2002) Combined hepatocellular-cholangiocarcinoma: a histopathologic, immunohistochemical, and in situ hybridization study. Am J Surg Pathol 26:989–997

    Article  PubMed  Google Scholar 

  49. International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983–993

    Google Scholar 

  50. Borzio M, Fargion S, Borzio F, Fracanzani AL, Croce AM, Stroffolini T, Oldani S, Cotichini R, Roncalli M (2003) Impact of large regenerative, low grade and high grade dysplastic nodules in hepatocellular carcinoma development. J Hepatol 39:208–214

    Article  PubMed  Google Scholar 

  51. Anthony PP, Vogel CL, Barker LF (1973) Liver cell dysplasia: a premalignant condition. J Clin Pathol 26:217–223

    Article  CAS  PubMed  Google Scholar 

  52. Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, Takahashi T (1983) Morphologic studies of the liver cell dysplasia. Cancer 51:2197–2205

    Article  CAS  PubMed  Google Scholar 

  53. Lee RG, Tsamandas AC, Demetris AJ (1997) Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis. Hepatology 26:1415–1422

    Article  CAS  PubMed  Google Scholar 

  54. Borzio M, Borzio F, Croce A, Sala M, Salmi A, Leandro G, Bruno S, Roncalli M (1997) Ultrasonography-detected macroregenerative nodules in cirrhosis: a prospective study. Gastroenterology 112:1617–1623

    Article  CAS  PubMed  Google Scholar 

  55. Theise ND, Schwartz M, Miller C, Thung SN (1992) Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 16:949–955

    Article  CAS  PubMed  Google Scholar 

  56. Terasaki S, Kaneko S, Kobayashi K, Nonomura A, Nakanuma Y (1998) Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: a prospective study. Gastroenterology 115:1216–1222

    Article  CAS  PubMed  Google Scholar 

  57. Kojiro M (2004) Focus on dysplastic nodules and early hepatocellular carcinoma: an Eastern point of view. Liver Transpl 10:S3–S8

    Article  PubMed  Google Scholar 

  58. Kondo Y, Niwa Y, Akikusa B, Takazawa H, Okabayashi A (1983) A histopathologic study of early hepatocellular carcinoma. Cancer 52:687–692

    Article  CAS  PubMed  Google Scholar 

  59. Sakamoto M, Hirohashi S, Shimosato Y (1991) Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 22:172–178

    Article  CAS  PubMed  Google Scholar 

  60. Roncalli M (2004) Hepatocellular nodules in cirrhosis: focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl 10:S9–S15

    Article  PubMed  Google Scholar 

  61. Arakawa M, Kage M, Sugihara S, Nakashima T, Suenaga M, Okuda K (1986) Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 91:198–208

    CAS  PubMed  Google Scholar 

  62. Wilkens L, Bredt M, Flemming P, Mengel M, Becker T, Klempnauer J, Kreipe H (2002) Comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) in the diagnosis of hepatocellular carcinoma. J Hepatobiliary Pancreat Surg 9:304–311

    Article  PubMed  Google Scholar 

  63. Chen ZM, Crone KG, Watson MA, Pfeifer JD, Wang HL (2005) Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma. Am J Surg Pathol 29:1600–1608

    Article  PubMed  Google Scholar 

  64. Lau SK, Weiss LM, Chu PG (2004) Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study. Am J Clin Pathol 122: 61–69

    Article  PubMed  Google Scholar 

  65. Krishna M, Lloyd RV, Batts KP (1997) Detection of albumin messenger RNA in hepatic and extrahepatic neoplasms. A marker of hepatocellular differentiation. Am J Surg Pathol 21:147–152

    Article  CAS  PubMed  Google Scholar 

  66. Ma CK, Zarbo RJ, Frierson HF, Jr, Lee MW (1993) Comparative immunohistochemical study of primary and metastatic carcinomas of the liver. Am J Clin Pathol 99:551–557

    CAS  PubMed  Google Scholar 

  67. Borscheri N, Roessner A, Rocken C (2001) Canalicular immunostaining of neprilysin (CD10) as a diagnostic marker for hepatocellular carcinomas. Am J Surg Pathol 25:1297–1303

    Article  CAS  PubMed  Google Scholar 

  68. Kondo Y (1985) Histologic features of hepatocellular carcinoma and allied disorders. Pathol Annu 20(Pt 2):405–430

    PubMed  Google Scholar 

  69. Thung SN, Gerber MA, Sarno E, Popper H (1979) Distribution of five antigens in hepatocellular carcinoma. Lab Invest 41:101–105

    CAS  PubMed  Google Scholar 

  70. Fucich LF, Cheles MK, Thung SN, Gerber MA, Marrogi AJ (1994) Primary vs metastatic hepatic carcinoma. An immunohistochemical study of 34 cases. Arch Pathol Lab Med 118:927–930

    CAS  PubMed  Google Scholar 

  71. Hurlimann J, Gardiol D (1991) Immunohistochemistry in the differential diagnosis of liver carcinomas. Am J Surg Pathol 15:280–288

    Article  CAS  PubMed  Google Scholar 

  72. Johnson DE, Herndier BG, Medeiros LJ, Warnke RA, Rouse RV (1988) The diagnostic utility of the keratin profiles of hepatocellular carcinoma and cholangiocarcinoma. Am J Surg Pathol 12:187–197

    Article  CAS  PubMed  Google Scholar 

  73. Minervini MI, Demetris AJ, Lee RG, Carr BI, Madariaga J, Nalesnik MA (1997) Utilization of hepatocyte-specific antibody in the immunocytochemical evaluation of liver tumors. Mod Pathol 10:686–692

    CAS  PubMed  Google Scholar 

  74. Kakar S, Muir T, Murphy LM, Lloyd RV, Burgart LJ (2003) Immunoreactivity of Hep Par 1 in hepatic and extrahepatic tumors and its correlation with albumin in situ hybridization in hepatocellular carcinoma. Am J Clin Pathol 119:361–366

    Article  PubMed  Google Scholar 

  75. Fan Z, van de Rijn M, Montgomery K, Rouse RV (2003) Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Mod Pathol 16:137–144

    Article  PubMed  Google Scholar 

  76. Lugli A, Tornillo L, Mirlacher M, Bundi M, Sauter G, Terracciano LM (2004) Hepatocyte paraffin 1 expression in human normal and neoplastic tissues: tissue microarray analysis on 3,940 tissue samples. Am J Clin Pathol 122:721–727

    Article  CAS  PubMed  Google Scholar 

  77. Scott FR, el-Refaie A, More L, Scheuer PJ, Dhillon AP (1996) Hepatocellular carcinoma arising in an adenoma: value of QBend 10 immunostaining in diagnosis of liver cell carcinoma. Histopathology 28:472–474

    Article  CAS  PubMed  Google Scholar 

  78. Kimura H, Nakajima T, Kagawa K, Deguchi T, Kakusui M, Katagishi T, Okanoue T, Kashima K, Ashihara T (1998) Angiogenesis in hepatocellular carcinoma as evaluated by CD34 immunohistochemistry. Liver 18:14–9

    Google Scholar 

  79. de Boer WB, Segal A, Frost FA, Sterrett GF (2000) Can CD34 discriminate between benign and malignant hepatocytic lesions in fine-needle aspirates and thin core biopsies? Cancer 90:273–278

    Article  PubMed  Google Scholar 

  80. Frachon S, Gouysse G, Dumortier J, Couvelard A, Nejjari M, Mion F, Berger F, Paliard P, Boillot O, Scoazec JY (2001) Endothelial cell marker expression in dysplastic lesions of the liver: an immunohistochemical study. J Hepatol 34:850–857

    Article  CAS  PubMed  Google Scholar 

  81. Gottschalk-Sabag S, Ron N, Glick T (1998) Use of CD34 and factor VIII to diagnose hepatocellular carcinoma on fine needle aspirates. Acta Cytol 42:691–696

    CAS  PubMed  Google Scholar 

  82. Di Tommaso L, Franchi G, Park YN, Fiamengo B, Destro A, Morenghi E, Montorsi M, Torzilli G, Tommasini M, Terracciano L, Tornillo L, Vecchione R, Roncalli M (2007) Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 45:725–734

    Article  PubMed  Google Scholar 

  83. Shafizadeh N, Ferrell LD, Kakar S (2008) Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum. Mod Pathol 21:1011–1018

    Article  CAS  PubMed  Google Scholar 

  84. Baumhoer D, Tornillo L, Stadlmann S, Roncalli M, Diamantis EK, Terracciano LM (2008) Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples. Am J Clin Pathol 129:899–906

    Article  PubMed  Google Scholar 

  85. Wang XY, Degos F, Dubois S, Tessiore S, Allegretta M, Guttmann RD, Jothy S, Belghiti J, Bedossa P, Paradis V (2006) Glypican-3 expression in hepatocellular tumors: diagnostic value for preneoplastic lesions and hepatocellular carcinomas. Hum Pathol 37:1435–1441

    Article  CAS  PubMed  Google Scholar 

  86. Kandil DH, Cooper K (2009) Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Adv Ana Pathol 16:125–129

    Article  CAS  Google Scholar 

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  1. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

    Gregory Y. Lauwers

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  1. Ambulatory Care Building, 2nd Floor, Department of Surgery, University of Louisville, S. Jackson Street 550, Louisville, 40202, Kentucky, USA

    Kelly M. McMasters

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Lauwers, G.Y. (2011). Hepatocellular Cancer: Pathologic Considerations. In: McMasters, K. (eds) Hepatocellular Carcinoma:. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-522-4_3

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