The Future: Combination Systemic Therapy for Hepatocellular Carcinoma

  • Ahmed O. Kaseb
  • Melanie B. Thomas


Hepatocellular carcinoma (HCC) is a potentially curable tumor by surgical resection, local ablation, or liver transplantation. However, the majority of patients with HCC present with advanced stage disease, which is most commonly, accompanied by severe background liver disease. Hence, curative treatments are feasible for only a small fraction of patients with localized disease.


HCC systemic therapy Carcinogenic pathways in HCC Growth factors Combination systemic therapy SHARP trial EGFR and VEGF pathways Sorafenib 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ahmed O. Kaseb
    • 1
  • Melanie B. Thomas
    • 2
  1. 1.Department of Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Division of Hematology/Oncology, Department of MedicineMedical University of South Carolina, Hollings Cancer CenterCharlestonUSA

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