Epidemiology and Pathogenesis of Hepatocellular Carcinoma

  • Manal M. Hassan
  • Ahmed O. Kaseb


Liver cancer is the sixth most common cancer worldwide and the third most common cause of cancer mortality, with more than 500,000 deaths annually [1, 2]. Hepatocellular carcinoma (HCC), which comprises most primary liver cancer cases, is rarely detected early and is usually fatal within a few months of diagnosis [3]. A recently published study indicated that the incidence rates of HCC tripled in the United States from 1975 through 2005 [4].


Hepatocellular carcinoma HCC HCC incidence HCC risk factors Diabetes mellitus HBV HCV 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Manal M. Hassan
    • 1
  • Ahmed O. Kaseb
    • 1
  1. 1.Department of Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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