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Immunoendocrinology: Scientific and Clinical Aspects pp 279–292Cite as

Natural History of Type 1 Diabetes

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Type 1 diabetes is a chronic autoimmune disease occurring in genetically predisposed individuals. Much interest has focused on the identification of susceptibility and protective genes. Genome-wide linkage analyses using the Type 1 diabetes, Genetics Consortium and three other datasets have confirmed that approximately 40% of the familial aggregation of type 1 diabetes can be attributed to allelic variation of HLA loci in the major histocompatibility locus on chromosome 6p21 (1  ). Also, INS (chromosome 11p15), CTLA4 (chromosome 2q33), and PTPN22 (chromosome 1p13) have clearly been demonstrated as susceptibility loci and nine further non-HLA linked regions show linkage with type 1 diabetes (1  ).

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Authors and Affiliations

  1. Department of Diabetes & Endocrinology, Royal Melbourne Hospital, Melbourne, VIC, Australia

    Spiros Fourlanos

  2. Walter and Eliza Hall Institute of Medical Research and Burnet Clinical Research Unit, Melbourne, VIC, Australia

    Leonard C. Harrison

  3. Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, VIC, Australia

    Peter G. Colman

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  1. Spiros Fourlanos
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  1. Health Sciences Center, Children's Hospital, University of Colorado, East 9th Avenue 4200, Denver, 80262, Colorado, USA

    George S. Eisenbarth

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Fourlanos, S., Harrison, L.C., Colman, P.G. (2011). Natural History of Type 1 Diabetes. In: Eisenbarth, G. (eds) Immunoendocrinology: Scientific and Clinical Aspects. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-478-4_17

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