Key Chapter Points:
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About half of all cancer patients experience pain. Pain affects 2 in 3 patients with metastatic disease.
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About half of all patients with cancer-related pain are under-treated for their pain.
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Pain in cancer patients is usually caused directly by cancer, but it may also occur due to cancer treatment effects and additional non-malignant conditions.
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Although most patients with cancer pain will be treated with opioids, therapy should include additional non-opioid and adjuvant medications, along with multidisciplinary pain management treatments.
Key Words
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References
Loscalzo MJ, Clark KL. Problem-related distress in cancer patients drives requests for help: a prospective study. Oncology 2007;21:1133–1138
Reid CM, Gooberman-Hill R, Hanks GW. Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. Ann Oncol 2008;19:44–48
Pisani P, Bray F, Parkin DM. Estimates of the world-wide prevalence of cancer for 25 sites in the adult population. Int J Cancer 2002;97:72–81
Salminen E, Izewska J, Anreo P. IAEA's role in the global management of cancer-focus on upgrading radiotherapy services. Acta Oncol 2005;44:816–824
Van den Beuken-van Everdingen MJ, de Rijke JM, Kessels AG, Schouten HC, van Kleff M, Patijn J. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann Oncol 2007;18:1437–1449
Larue F, Colleau SM, Brasseur L, Cleeland CS. Multicentre study of cancer pain and its treatment in France. BMJ 1995;310:1034–1037
Caraceni A, Portenoy. An international survey of cancer pain characteristics and syndromes. Pain 1999;82:263–274
Vassiliou V, Kalogeropoulou C, Petsas T, Leotsinidis M, Kardamakis D. Clinical and radiological evaluation of patients with lytic, mixed and sclerotic bone metastases from solid tumors: is there a correlation between clinical status of patients and type of bone metastases? Clin Exp Metastasis 2007;24:49–56
Bernardi M, Catania G, Tridello G. Knowledge and attitudes about cancer pain management. A national survey of Italian hospice nurses. Cancer Nurs 2007;30:E20–E26
Li KK, Harris K, Hadi S, Crow E. What should be the optimal cut points for mild, moderate, and severe pain? J Palliative Med 2007;10:1338–1346
Bender JL, Hohendael J, Wong J, et al. What patients with cancer want to know about pain: a qualitative study. J Pain Symptom Manag 2008;35:177–187
http://www.nccn.org/professionals/physician_gls/default.asp(accessed September 10, 2007)
Beck SL, Falkson G. Prevalence and management of cancer pain in South Africa. Pain 2001;94:75–84
Glare P, Walsh D, Sheehan D. The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain. Am J Hosp Palliative Med 2006;23:229–235
Lawlor PG. The panorama of opioid-related cognitive dysfunction in patients with cancer: a critical literature appraisal. Cancer 2002;94:1836–1853
Leipzig RM, Goodman H, Gray G, Erle H, Reindenberg MM. Reversible, narcotic-associated mental status impairment in patients with metastatic cancer. Pharmacology 1987;35:47–54
Sjøgren P, Olsen AK, Thomsen AB, Dalberg J. Neuropsychological performance in cancer patients: the role of oral opioids, pain and performance status. Pain 2000;86:237–245
Cherny N, Ripamonti C, Pereira J, et al. Strategies to manage the adverse effects of oral morphine: an evidence-based report. J Clin Oncol 2001;19:2542–2554
Højsted J, Sjøgren P. Addiction to opioids in chronic pain patients: a literature review. Eur J Pain 2007;11:490–518
Payne R. Recognition and diagnosis of breakthrough pain. Pain Med 2007;8 (suppl 1): S3–S7
Caraceni A, Martini C, Zecca E, et al. Breakthrough pain characteristics and syndromes in patients with cancer pain. An international survey. Palliat Med 2004;18:177–183
Hwang SS, Chang VT, Kasimis B. Cancer breakthrough pain characteristics and responses to treatment at a VA medical center. Pain 2003;101:55–64
McCarberg BH. The treatment of breakthrough pain. Pain Med 2007;8 (suppl 1):S8–S13
Portenoy RK, Taylor D, Messina J, Tremmel L. A randomized, placebo-controlled study of fentanyl buccal tablet for breakthrough pain in opioid-treated patients with cancer. Clin J Pain 2006;22:805–811
Bezjak A, Dixon P, Brundage M, et al. Randomized phase III trial of single versus fractionated thoracic radiation in the palliation of patients with lung cancer. Int J Radiat Oncol Biol Phys 2002;54:719–728
Smith TJ, Staats PS, Deer R, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival. J Clin Oncol 2002;20:4040–4049
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Marcus, D.A. (2009). Cancer Pain. In: Chronic Pain. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-60327-465-4_13
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DOI: https://doi.org/10.1007/978-1-60327-465-4_13
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