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Pathophysiology of Type-2 Diabetes

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Part of the book series: Current Clinical Practice ((CCP))

Abstract

Appropriate treatment of type-2 diabetes is dependent upon the knowledge of the pathophysiology of the disease, the mechanisms underlying hyperglycemia, and the efficacy of various oral agents and insulins to improve fasting or postprandial hyperglycemia.

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References

  1. Tuomi T, Carlsson A, Li H. Clinical and genetic characteristics of type-2 diabetes with and without GAD antibodies. Diabetes 1999;48(1):150–157.

    Article  PubMed  CAS  Google Scholar 

  2. Groop LC. Pathogenesis of insulin resistance in type 2 diabetes: a collision between thrifty genes and an affluent environment. Diabetes Obes Metab I Suppl 1999;1:51–57.

    Google Scholar 

  3. Gillies Cl. Different strategies for screening and prevention of type-2 diabetes in adults. BMJ 2008; 336(7654):1180–1185.

    Article  PubMed  Google Scholar 

  4. LeRoith D. Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 2002;113(suppl 6A):3S–11S.

    Article  PubMed  CAS  Google Scholar 

  5. Goldstein BJ. Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 2002;90:3G–10G.

    Article  PubMed  CAS  Google Scholar 

  6. Haffner SM. The insulin resistance syndrome revisted. Diabetes Care 1996;19:275–277.

    PubMed  CAS  Google Scholar 

  7. Grundy SM. Obesity, metabolic syndrome, and coronary atherosclerosis. Circulation 2002;105:2696–2698.

    Article  PubMed  Google Scholar 

  8. Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994;331:1428–1436.

    Article  PubMed  CAS  Google Scholar 

  9. Budzikowski A. Obesity, diabetes, and hypertension: a growing epidemic. Cardiol Rev 2003;20(9):9–10.

    Google Scholar 

  10. Narayan KM, Imperatore G, et al. Targeting people with pre-diabetes. BMJ 2002;325:403–404.

    Article  PubMed  Google Scholar 

  11. Young TK, et al. Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch Pediatr Adolesc Med 2002;156:651–655.

    Article  PubMed  Google Scholar 

  12. Westermark GT, Westermark P. Widespread amyloid deposition in transplanted human pancreatic islets. N Engl J Med 2008;359(9):977–979.

    Article  PubMed  CAS  Google Scholar 

  13. Jack L, et al. Aging Americans and diabetes. Geriatrics 2004;59(4):14–17.

    Google Scholar 

  14. Sobel BE. Insulin resistance and thrombosis. Am J Cardiol 1999;84(1A):37J–41J.

    Article  PubMed  CAS  Google Scholar 

  15. Shepherd PR, Kahn BB. Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus. N Engl J Med 1999;341:248.

    Article  PubMed  CAS  Google Scholar 

  16. Gaede P. Multifactorial intervention and cardiovascular disease in patients with type-2 diabetes. N Engl J Med 2003;348:383.

    Article  PubMed  Google Scholar 

  17. Ix J, Wassel C, Kanaya A. Fetuin-A and incident diabetes mellitus in older persons. JAMA 2008;300(2): 182–188.

    Article  PubMed  CAS  Google Scholar 

  18. Sinha R, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802–810.

    Article  PubMed  CAS  Google Scholar 

  19. Leahy JL, Bonner-Weir S. Beta cell dysfunction induced by chronic hyperglycemia: current ideas on mechanism of impaired glucose induced insulin secretion. Diabetes Care 1992;15:442.

    Article  PubMed  CAS  Google Scholar 

  20. Ferrannini E. Insulin resistance versus insulin deficiency in non-insulin dependent diabetes mellitus: problems and prospects. Endocr Rev 1998;19:477.

    Article  PubMed  CAS  Google Scholar 

  21. Fagan TC, Deedwaqnia PC. The cardiovascular dysmetabolic syndrome. Am J Med 1998;105(suppl 1A):77S–82S.

    Article  PubMed  CAS  Google Scholar 

  22. Cubeddu LX, Hoffmann IS. Insulin resistance and upper normal glucose levels in hypertension: a review. J Hum Hypertens 2002;16(suppl 1):S52–S55.

    Article  PubMed  CAS  Google Scholar 

  23. Seely BL, Olefsky JM, Insulin Resistance. David E Mohier, ed. Wiley & Sons Ltd. Publisher 1993;187–252.

    Google Scholar 

  24. Deedwania PC. Mechanism of the deadly quartet. Can J Cardiol 2000;16(suppl E):17E–20E.

    PubMed  Google Scholar 

  25. Consensus Report of the American Diabetes Association. Diabetes Care 1998; 21:310–314.

    Google Scholar 

  26. Rose G. High risk and population strategies of prevention: ethical considerations. Ann Med 1989; 21:409–413.

    Article  PubMed  CAS  Google Scholar 

  27. Narayan KM, et al. Lifetime risk for diabetes mellitus in the United States. JAMA 2003;290(14):1884–1890.

    Google Scholar 

  28. Harris M. Undiagnosed type 2 diabetes: clinical and public health issues. Diabetes Care 1993;16:643.

    Google Scholar 

  29. United Kingdom Prospective Diabetes Study (UKPDS) Group. Intensive blood glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837–853.

    Article  Google Scholar 

Supplementary Readings

  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33(suppl 1):S62–S69.

    Article  Google Scholar 

  • Boden G. Pathogenesis of type 2 diabetes: insulin resistance. Endocrinol Metab Clin North Am 2001;30:801–815.

    Article  PubMed  CAS  Google Scholar 

  • Centers for Disease Control and Prevention. 2007 national diabetes fact sheet. http//www.cdc.gov/diabetes/pubs/factsheet07.htm

  • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–986.

    Article  Google Scholar 

  • Desai J, Geiss L, Muktar Q, et al. Public health surveillance of diabetes in the United States. J Public Health Manag Pract 2003;Suppl:S44–S51.

    PubMed  Google Scholar 

  • Grimble RF. Inflammatory status and insulin resistance. Curr Opin Clin Nutr Metab Care 2002;5:551–559.

    Article  PubMed  CAS  Google Scholar 

  • Kahn BB. Gluocse transport: pivotal step in insulin action. Diabetes 1996;45:1644–1654.

    Article  PubMed  CAS  Google Scholar 

  • Marshall JA, Bessesen DH. Dietary fat and the development of type 2 diabetes. Diabetes Care 2002;25:620–622.

    Article  PubMed  Google Scholar 

  • Patel P, Macerollo A. Diabetes mellitus: diagnosis and screening. Am Fam Physician 2010;81(7):863–870.

    PubMed  Google Scholar 

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Diplomate American Board of Internal Medicine

Diplomate American Board of Clinical Lipidology

Diplomate American Board of Vascular Medicine

Clinical Hypertension Specialist (American Society of Hypertension Certified)

Vascular Ultrasound (American Registry of Diagnostic Sonography Certified)

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Codario, R.A. (2011). Pathophysiology of Type-2 Diabetes. In: Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-441-8_1

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  • DOI: https://doi.org/10.1007/978-1-60327-441-8_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-440-1

  • Online ISBN: 978-1-60327-441-8

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