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Managing Depression in Primary Care

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Pharmacotherapy of Depression
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Abstract

The need to manage depression more effectively in primary care is well established. Major depressive disorder is a common, chronic but episodic and costly condition for which primary care physicians provide the majority of care (1). Among nonpsychotic patients, symptom composition and severity differs little from adults presenting to psychiatrists (2). Patients who have chronic medical conditions such as diabetes or ischemic heart disease with concomitant major depression have poorer outcomes than do those without depression. In spite of its frequency and importance, recognition, evaluation, and management in primary care is often less than optimal, with up to 50% of depressed patients going unrecognized. In this chapter, we will focus on aspects of managing care of depression in primary care settings necessary.

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References

  1. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095–105.

    Article  PubMed  Google Scholar 

  2. Gaynes BN, Rush AJ, Trivedi MH, Wisniewski SR, Balasubramani GK, Spencer DC, et al. Major depression symptoms in primary care and psychiatric care settings: a cross-sectional analysis. Ann Fam Med. 2007;5(2):126–34.

    Article  PubMed  Google Scholar 

  3. Murray CJL, Lopez AD, editors. A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Cambridge: Harvard School of Public Health on behalf of the World Health Organization and the World Bank, Harvard University Press; 1996.

    Google Scholar 

  4. Kroenke K, Spitzer RL, Williams JB, Linzer M, Hahn SR, deGruy FV, III, et al. Physical symptoms in primary care. Predictors of psychiatric disorders and functional impairment. Arch Fam Med. 1994;3(9):774–9.

    Google Scholar 

  5. U.S. Preventive Services Task Force. Screening for depression: recommendations and rationale. Ann Intern Med. 2002;136(10):760–4.

    Google Scholar 

  6. Williams JW, Jr., Pignone M, Ramirez G, Perez Stellato C. Identifying depression in primary care: a literature synthesis of case-finding instruments. Gen Hosp Psychiatry. 2002;24(4):225–37.

    Article  PubMed  Google Scholar 

  7. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity ­measure. J Gen Intern Med. 2001;16(9):606–13.

    Article  PubMed  CAS  Google Scholar 

  8. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, et al. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003;54(5):573–83.

    Article  PubMed  Google Scholar 

  9. Beck AT, Steer RA, Ball R, Ranieri W. Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. J Pers Assess. 1996;67(3):588–97.

    Article  PubMed  CAS  Google Scholar 

  10. Williams JW, Jr., Noel PH, Cordes JA, Ramirez G, Pignone M. Is this patient clinically depressed? JAMA. 2002;287(9):1160–70.

    Article  PubMed  Google Scholar 

  11. van Marwijk HW, Wallace P, de Bock GH, Hermans J, Kaptein AA, Mulder JD. Evaluation of the feasibility, reliability and diagnostic value of shortened versions of the geriatric depression scale. Br J Gen Pract. 1995;45(393):195–9.

    PubMed  Google Scholar 

  12. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561–71.

    Article  PubMed  CAS  Google Scholar 

  13. Mueller TI, Leon AC, Keller MB, Solomon DA, Endicott J, Coryell W, et al. Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. AmJ Psychiatry. 1999;156(7):1000–6.

    PubMed  CAS  Google Scholar 

  14. Shalev AY, Freedman S, Peri T, Brandes D, Sahar T, Orr SP, et al. Prospective study of posttraumatic stress disorder and depression following trauma. Am J Psychiatry. 1998;155(5):630–7.

    PubMed  CAS  Google Scholar 

  15. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631):386–9.

    Article  PubMed  CAS  Google Scholar 

  16. Katon W, Lin EH, Kroenke K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry. 2007;29(2):147–55.

    Article  PubMed  Google Scholar 

  17. Sturm R, Gresenz CR. Relations of income inequality and family income to chronic medical conditions and mental health disorders: national survey. BMJ. 2002;324(7328):20–3.

    Article  PubMed  Google Scholar 

  18. Hippisley-Cox J, Coupland C, Pringle M, Crown N, Hammersley V. Married couples’ risk of same disease: cross sectional study. BMJ. 2002;325(7365):636.

    Article  PubMed  Google Scholar 

  19. Freeman EW, Sammel MD, Lin H, Nelson DB. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry. 2006;63(4):375–82.

    Article  PubMed  CAS  Google Scholar 

  20. Freeman EW, Sammel MD, Liu L, Gracia CR, Nelson DB, Hollander L. Hormones and ­menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatry. 2004;61(1):62–70.

    Article  PubMed  CAS  Google Scholar 

  21. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):617–27.

    Article  PubMed  Google Scholar 

  22. Wittchen HU, Kessler RC, Pfister H, Lieb M. Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatr Scand. 2000(406): 14–23.

    Google Scholar 

  23. Kroenke K, Spitzer RL, Williams JB, Monahan PO, Lowe B. Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection. Ann Intern Med. 2007;146(5): 317–25.

    PubMed  Google Scholar 

  24. Depression in Primary Care. Volume 1. Detection and Diagnosis: US Department of Health and Human Services Public Health Service; 1993.

    Google Scholar 

  25. Zisook S, Dunn LB. Dementia and bereavement: adverse life experiences complicating depression in lateral life. Prim Care Companion J Clin Psychiatry. 2000;2(suppl 5):25–31.

    Google Scholar 

  26. Simon GE, Von Korff M. Medical co-morbidity and validity of DSM-IV depression criteria. Psychol Med. 2006;36(1):27–36.

    Article  PubMed  Google Scholar 

  27. Beekman A. Depression and medical illness in later life. Prim Care Companion J Clin Psychiatry. 2000;2(suppl 5):9–14.

    Google Scholar 

  28. Kupfer DJ, Frank E, Grochocinski VJ, Cluss PA, Houck PR, Stapf DA. Demographic and clinical characteristics of individuals in a bipolar disorder case registry. J Clin Psychiatry. 2002;63(2):120–5.

    Article  PubMed  Google Scholar 

  29. Post RM, Denicoff KD, Leverich GS, Altshuler LL, Frye MA, Suppes TM, et al. Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method. J Clin Psychiatry. 2003;64(6):680–90; quiz 738–9.

    Google Scholar 

  30. Hirschfeld RM. The mood disorder questionnaire: a simple, patient-rated screening ­instrument for bipolar disorder. Prim Care Companion J Clin Psychiatry. 2002;4(1):9–11.

    Article  PubMed  Google Scholar 

  31. Hirschfeld RM, Holzer C, Calabrese JR, Weissman M, Reed M, Davies M, et al. Validity of the mood disorder questionnaire: a general population study. Am J Psychiatry. 2003;160(1): 178–80.

    Article  PubMed  Google Scholar 

  32. Goldsmith S, Pellmar T, Kleinman A, Bunney W, editors. Reducing suicide: a national imperative. Washington: Institute of Medicine National Academies Press; 2002.

    Google Scholar 

  33. Harris EC, Barraclough B. Suicide as an outcome for mental disorders. A meta-analysis. BrJ Psychiatry. 1997;170:205–28.

    Article  PubMed  CAS  Google Scholar 

  34. Bruce SE, Weisberg RB, Dolan RT, Machan JT, Kessler RC, Manchester G, et al. Trauma and posttraumatic stress disorder in primary care patients. Prim Care Companion J Clin Psychiatry. 2001;3(5):211–7.

    Article  PubMed  Google Scholar 

  35. Gibbons RD, Brown CH, Hur K, Marcus SM, Bhaumik DK, Erkens JA, et al. Early evidence on the effects of regulators’ suicidality warnings on SSRI prescriptions and suicide in children and adolescents. Am J Psychiatry. 2007;164(9):1356–63.

    Article  PubMed  Google Scholar 

  36. Gaynes BN, West SL, Ford CA, Frame P, Klein J, Lohr KN. Screening for suicide risk in adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2004;140(10):822–35.

    PubMed  Google Scholar 

  37. Michel K. Suicide prevention and primary care. In: Hawton K, Heeringen, KV, editors. The international handbook of suicide and attempted suicide. New York: Wiley; 2000.

    Google Scholar 

  38. Spicer R, Miller T. Suicide acts in 8 states: incidence and case fatality rates by demographics and method. Am J Public Health. 2000;90(12):1885–91.

    Article  PubMed  CAS  Google Scholar 

  39. Kaplan H, Sadock B. Psychiatric emergencies. In: Kaplan H, Sadock B, Grebb J, editors. Synopsis of psychiatry, 7th ed. Baltimore: Williams Wilkins; 1994.

    Google Scholar 

  40. Miller M, Azrael D, Hemenway D. The epidemiology of case fatality rates for suicide in the northeast. Ann Emerg Med. 2004;43(6):723–30.

    Article  PubMed  Google Scholar 

  41. Schernhammer ES, Colditz G. Suicide rates among physicians: a quantitative and gender assessment (meta-analysis). Am J Psychiatry. 2004;161(12):2295–302.

    Article  PubMed  Google Scholar 

  42. Heikkinen M, Isometsa E, Marttunen M, Aro H, Lonnqvist J. Social factors in suicide. BrJ Psychiatry. 1995;167(6):747–53.

    Article  PubMed  CAS  Google Scholar 

  43. Beck A, Steer R, Beck J, Newman C. Hopelessness, depression, suicidal ideation, and clinical diagnosis of depression. Suicide Life Threat Behav. 1993;23(2):139–45.

    PubMed  CAS  Google Scholar 

  44. Dannenberg A, McNeil J, Brundage J, Brookmeyer R. Suicide and HIV infection. Mortality follow-up of 4147 HIV-seropositive military service applicants. JAMA. 1996;276(21): 1743–6.

    Article  PubMed  CAS  Google Scholar 

  45. Hawton K. Suicide and attempted suicide. In: Pankel E, editor. Handbook of affective ­disorders, 2nd ed. New York: Guilford; 1992.

    Google Scholar 

  46. Agerbo E. Risk of suicide and spouse’s psychiatric illness or suicide: nested case-control study. BMJ. 2003;327(7422):1025–6.

    Article  PubMed  Google Scholar 

  47. Moscicki E. Epidemiology of suicide. In: Goldsmith S, editor. Suicide prevention and intervention. Washington: National Academy Press; 2001.

    Google Scholar 

  48. Qin P, Mortensen PB. The impact of parental status on the risk of completed suicide. Arch Gen Psychiatry. 2003;60(8):797–802.

    Article  PubMed  Google Scholar 

  49. Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, et al. The Inventory of Depressive Symptomatology, Clinician Rating (IDS-C) and Self-Report (IDS-SR), and the Quick Inventory of Depressive Symptomatology, Clinician Rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psychometric evaluation. Psychol Med. 2004;34(1):73–82.

    Article  PubMed  CAS  Google Scholar 

  50. Hollon SD, Shelton RC, Wisniewski S, Warden D, Biggs MM, Friedman ES, et al. Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial. J Psychiatr Res. 2006;40(1):59–69.

    Article  PubMed  Google Scholar 

  51. Blom MB, Spinhoven P, Hoffman T, Jonker K, Hoencamp E, Haffmans PM, et al. Severity and duration of depression, not personality factors, predict short term outcome in the treatment of major depression. J Affect Disord. 2007;104(1–3):119–126.

    Google Scholar 

  52. Thase ME, Simons AD, Cahalane J, McGeary J, Harden T. Severity of depression and response to cognitive behavior therapy. Am J Psychiatry. 1991;148(6):784–9.

    PubMed  CAS  Google Scholar 

  53. Nease DE, Jr., Volk RJ, Cass AR. Does the severity of mood and anxiety symptoms predict health care utilization? J Fam Pract. 1999;48(10):769–77.

    PubMed  Google Scholar 

  54. Von Korff M, Goldberg D. Improving outcomes in depression. BMJ. 2001;323(7319): 948–9.

    Article  Google Scholar 

  55. Katzelnick DJ, Simon GE, Pearson SD, Manning WG, Helstad CP, Henk HJ, et al. Randomized trial of a depression management program in high utilizers of medical care. Arch Fam Med. 2000;9(4):345–51.

    Article  PubMed  CAS  Google Scholar 

  56. Gensichen J, Beyer M, Muth C, Gerlach FM, Von Korff M, Ormel J. Case management to improve major depression in primary health care: a systematic review. Psychol Med. 2006;36(1):7–14.

    Article  PubMed  CAS  Google Scholar 

  57. Lin EH, Simon GE, Katzelnick DJ, Pearson SD. Does physician education on depression management improve treatment in primary care? J Gen Intern Med. 2001;16(9):614–9.

    Article  PubMed  CAS  Google Scholar 

  58. Morey E, Thacher JA, Craighead WE. Patient preferences for depression treatment programs and willingness to pay for treatment. J Ment Health Policy Econ. 2007;10(2):73–85.

    PubMed  Google Scholar 

  59. Lin EH, Von Korff M, Katon W, Bush T, Simon GE, Walker E, et al. The role of the primary care physician in patients’ adherence to antidepressant therapy. Med Care. 1995;33(1): 67–74.

    Article  PubMed  CAS  Google Scholar 

  60. Schulberg HC, Raue PJ, Rollman BL. The effectiveness of psychotherapy in treating depressive disorders in primary care practice: clinical and cost perspectives. Gen Hosp Psychiatry. 2002;24(4):203–12.

    Article  PubMed  Google Scholar 

  61. Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, et al. A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med. 2000;342(20):1462–70.

    Article  PubMed  CAS  Google Scholar 

  62. Wolf NJ, Hopko DR. Psychosocial and pharmacological interventions for depressed adults in primary care: A critical review. Clin Psychol Rev. 2008;28(1):131–61.

    Article  PubMed  Google Scholar 

  63. Depression Guideline Panel. Depression in Primary Care: Treatment of Major Depression: Clinical Practice Guideline. Rockville, MD: US Dept of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research. AHCPR publication 93-0551; 1993.

    Google Scholar 

  64. Hansen RA, Gartlehner G, Lohr KN, Gaynes BN, Carey TS. Efficacy and safety of second-generation antidepressants in the treatment of major depressive disorder. Ann Intern Med. 2005;143(6):415–26.

    PubMed  CAS  Google Scholar 

  65. Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry. 2007;22(7):613–26.

    Article  PubMed  Google Scholar 

  66. Serebruany VL, Glassman AH, Malinin AI, Atar D, Sane DC, Oshrine BR, et al. Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. Eur J Heart Fail. 2003;5(4):517–21.

    Article  PubMed  CAS  Google Scholar 

  67. Glassman AH, Bigger JT, Gaffney M, Van Zyl LT. Heart rate variability in acute coronary syndrome patients with major depression: influence of sertraline and mood improvement. Arch Gen Psychiatry. 2007;64(9):1025–31.

    Article  PubMed  Google Scholar 

  68. Siepmann T, Ziemssen T, Mueck-Weymann M, Kirch W, Siepmann M. The effects of venlafaxine on autonomic functions in healthy volunteers. J Clin Psychopharmacol. 2007;27(6):687–91.

    Article  PubMed  CAS  Google Scholar 

  69. Fava M, Judge R, Hoog SL, Nilsson ME, Koke SC. Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry. 2000;61(11):863–7.

    Article  PubMed  CAS  Google Scholar 

  70. Hemeryck A, Belpaire FM. Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update. Curr Drug Metab. 2002;3(1):13–37.

    Article  PubMed  CAS  Google Scholar 

  71. Murphy GM, Jr., Kremer C, Rodrigues HE, Schatzberg AF. Pharmacogenetics of antidepressant medication intolerance. Am J Psychiatry. 2003;160(10):1830–5.

    Article  PubMed  Google Scholar 

  72. Cyranowski JM, Frank E, Cherry C, Houck P, Kupfer DJ. Prospective assessment of sexual function in women treated for recurrent major depression. J Psychiatr Res. 2004;38(3):267–73.

    Article  PubMed  Google Scholar 

  73. Zisook S, Rush AJ, Haight BR, Clines DC, Rockett CB. Use of bupropion in combination with serotonin reuptake inhibitors. Biol Psychiatry. 2006;59(3):203–10.

    Article  PubMed  CAS  Google Scholar 

  74. Rush AJ. STAR*D: what have we learned? Am J Psychiatry. 2007;164(2):201–4.

    Article  PubMed  Google Scholar 

  75. Triezenberg D, Vachon D, Helmen J, Schneider D. Clinical inquiries: how should you manage a depressed patient unresponsive to an SSRI? J Fam Pract. 2006;55(12):1081–2; 7.

    Google Scholar 

  76. Nierenberg AA, Fava M, Trivedi MH, Wisniewski SR, Thase ME, McGrath PJ, et al. A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry. 2006;163(9):1519–30; quiz 665.

    Google Scholar 

  77. Papakostas GI, Shelton RC, Smith J, Fava M. Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis. J Clin Psychiatry. 2007;68(6):826–31.

    Article  PubMed  CAS  Google Scholar 

  78. Dunn AL, Trivedi MH, Kampert JB, Clark CG, Chambliss HO. Exercise treatment for depression: efficacy and dose response. Am J Prev Med. 2005;28(1):1–8.

    Article  PubMed  Google Scholar 

  79. Blumenthal JA, Babyak MA, Doraiswamy PM, Watkins L, Hoffman BM, Barbour KA, et al. Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder. Psychosom Med. 2007;(69):587–596.

    Google Scholar 

  80. Ostacher MJ. Comorbid alcohol and substance abuse dependence in depression: impact on the outcome of antidepressant treatment. Psychiatr Clin North Am. 2007;30(1):69–76.

    Article  PubMed  Google Scholar 

  81. Paykel ES, Ramana R, Cooper Z, Hayhurst H, Kerr J, Barocka A. Residual symptoms after partial remission: an important outcome in depression. Psychol Med. 1995;25(6):1171–80.

    Article  PubMed  CAS  Google Scholar 

  82. Judd LL, Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, et al. Major depressive disorder: a prospective study of residual subthreshold depressive symptoms as predictor of rapid relapse. J Affect Disord. 1998;50(2–3):97–108.

    Article  PubMed  CAS  Google Scholar 

  83. Kennedy N, Foy K. The impact of residual symptoms on outcome of major depression. Curr Psychiatry Rep. 2005;7(6):441–6.

    Article  PubMed  Google Scholar 

  84. Ezquiaga E, Garcia A, Pallares T, Bravo MF. Psychosocial predictors of outcome in major depression: a prospective 12-month study. J Affect Disord. 1999;52(1–3):209–16.

    Article  PubMed  CAS  Google Scholar 

  85. Paykel ES. Continuation and maintenance therapy in depression. Br Med Bull. 2001;57:145–59.

    Article  PubMed  CAS  Google Scholar 

  86. Thase ME. Preventing relapse and recurrence of depression: a brief review of therapeutic options. CNS Spectr. 2006;11(12 suppl 15):12–21.

    PubMed  Google Scholar 

  87. Anon. Practice guideline for the treatment of patients with major depressive disorder (­revision). American Psychiatric Association. Am J Psychiatry. 2000;157(4 suppl):1–45.

    Google Scholar 

  88. Demyttenaere K, Enzlin P, Dewe W, Boulanger B, De Bie J, De Troyer W, et al. Compliance with antidepressants in a primary care setting, 1: Beyond lack of efficacy and adverse events. J Clin Psychiatry. 2001;62(suppl 22):30–3.

    PubMed  CAS  Google Scholar 

  89. Rush AJ, Kraemer HC, Sackeim HA, Fava M, Trivedi MH, Frank E, et al. Report by the ACNP Task Force on response and remission in major depressive disorder. Neuropsychopharmacology. 2006;31(9):1841–53.

    Article  PubMed  Google Scholar 

  90. American Psychiatric Association., American Psychiatric Association. Task Force on DSM-IV. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. 4th ed. Washington: American Psychiatric Association; 2000.

    Google Scholar 

  91. Kroenke K, Spitzer R. The PHQ-9: a new depression and diagnostic severity measure. Psychiatr Ann. 2002;32:509–21.

    Google Scholar 

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Culpepper, L., Johnson, P. (2011). Managing Depression in Primary Care. In: Ciraulo, D., Shader, R. (eds) Pharmacotherapy of Depression. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-435-7_10

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