Abstract
Drug-induced parkinsonism (DIP) is a common adverse effect of treatment with antipsychotic/neuroleptic drugs which block dopamine receptors in the striatum. These drugs include the phenothiazines, thioxanthenes, butyrophenones, and the newer-generation “atypical” antipsychotic drugs such as risperidone, olanzapine, ziprasidone, and aripiprazole. Antiemetics which block dopamine receptors such as prochlorperazine and metoclopramide and certain calcium channel blockers such as flunarizine are also common causes of DIP. DIP may be indistinguishable from Parkinson’s disease (PD) and includes various combinations of bradykinesia, rigidity, resting and action tremor. The incidence of DIP increases with age. In fact, asymmetric motor findings are not uncommon and in older individuals may represent an unmasking of subclinical PD.
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Patient is in hospital displaying facial masking, reduced blink frequency, global bradykinesia, slow and hypokinetic, right finger and toe tapping, and slow gait with flexed posture, absent arm swing and en bloc turns following 10 days of treatment with haloperidol for hemiballismus (see Chap. 75).
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Bhidayasiri, R., Tarsy, D. (2012). Drug-Induced Parkinsonism. In: Movement Disorders: A Video Atlas. Current Clinical Neurology. Humana, Totowa, NJ. https://doi.org/10.1007/978-1-60327-426-5_20
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DOI: https://doi.org/10.1007/978-1-60327-426-5_20
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Publisher Name: Humana, Totowa, NJ
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