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Targeted Cancer Therapy pp 21–42Cite as

Targeted Therapy in Acute Myelogenous Leukemia

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Part of the book series: Current Clinical Oncology™ ((CCO))

Abstract

This chapter explores the antiacute myelogenous leukemia effects of various targeted therapies. It discusses combinations of targeted therapies with each other and particularly with chemotherapy. The extent to which a “targeted therapy’s” target is known a priori and the adequacy of relevant trial designs are discussed along with the relevance of new criteria for response, which patients are candidates for targeted therapy, and the appropriateness of conventional statistical methodology. The utility of identifying the “maximum tolerated” dose and emphasis on single-arm, Phase II trials followed by large randomized trials versus alternative methods such as a focus on the “optimal biologic” dose, more adaptive single-arm designs, and smaller randomized trials are also covered.

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Authors
  1. Elihu Estey MD
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Editors and Affiliations

  1. Department of Investigational Cancer Therapeutics Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

    Razelle Kurzrock MD

  2. Department of Clinical Research, The University of Texas MD Anderson Cancer Center, Houston, TX

    Maurie Markman

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© 2008 Humana Press, Totowa, NJ

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Estey, E. (2008). Targeted Therapy in Acute Myelogenous Leukemia. In: Kurzrock, R., Markman, M. (eds) Targeted Cancer Therapy. Current Clinical Oncology™. Humana Press. https://doi.org/10.1007/978-1-60327-424-1_2

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  • DOI: https://doi.org/10.1007/978-1-60327-424-1_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-423-4

  • Online ISBN: 978-1-60327-424-1

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