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Apoptosis in Liver Injury and Liver Diseases

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Essentials of Apoptosis

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Abstract

The liver is a multifunctional organ that has important roles such as metabolism, synthesis, and detoxification. Enhanced hepatocyte apoptosis and impaired liver regeneration are the most common liver disorders in acute liver failure. Hepatocyte apoptosis also emerges as a fundamental component of chronic liver diseases. Liver tissue fibrosis is triggered by hepatocyte apoptosis, and the excess fibrosis causes liver disease to progress to cirrhosis, which causes chronic liver failure. Although hepatocyte apoptosis is a cardinal feature of liver diseases, it is generally believed that apoptosis deletes hepatitis virus-infected hepatocytes and prevents carcinogenesis and that antiapoptotic factors are activated in the chronic injured liver. This chapter highlights the mechanism of pro- and antiapoptosis in liver diseases’ underlying molecular basis.

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Authors and Affiliations

  1. Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan

    Yosuke Osawa & Ekihiro Seki

  2. Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California 92093, USA

    David A. Brenner

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  1. Yosuke Osawa
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  2. Ekihiro Seki
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    Osawa, Y., Seki, E., Brenner, D.A. (2009). Apoptosis in Liver Injury and Liver Diseases. In: Dong, Z., Yin, XM. (eds) Essentials of Apoptosis. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-381-7_24

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