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Animal Models for Cardiac Research

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Handbook of Cardiac Anatomy, Physiology, and Devices

Abstract

The modern era of cardiac surgery is largely considered to have begun in the animal research laboratories. Today, animal models continue to be used for the study of cardiovascular diseases and are required for the preclinical assessment of pharmaceuticals, mechanical devices, therapeutic procedures, and/or continuation therapies. This chapter was designed to provide readers and potential investigators with important background information necessary for the process of matching an experimental hypothesis to an animal species that will serve as an appropriate model for studying a specific cardiovascular disease or for testing a given medical device. A review of the current animal models used in cardiac research is provided and arranged by disease state. Critical factors to consider when choosing an appropriate animal model including cost, reproducibility, and degree of similarity of the model to human disease are discussed. Thus, this chapter can be utilized as a practical guide for planning of research protocols.

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Author information

Authors and Affiliations

  1. Department of Surgery, University of Minnesota, Experimental Surgical Services, MMC 220, 420 Delaware St. SE, 55455, Minneapolis, MN, USA

    Richard W. Bianco

  2. Division of Cardiac Surgery, Brigham and Women’s Hospital, 75 Francis St., 02115, Boston, MN, USA

    Robert P. Gallegos

  3. Department of Radiology, College of Medicine, University of Florida, 75 Francis St., 32610-0374, PO Box 100374, Gainesville, FL, USA

    Andrew L. Rivard

  4. Departments of Surgery, Laboratory Medicine, and Pathology, University of Minnesota, MMC 220, 420 Delaware St. SE, 55455, Minneapolis, MN, USA

    Agustin P. Dalmasso

Authors
  1. Richard W. Bianco
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  2. Robert P. Gallegos
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  3. Andrew L. Rivard
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  4. Jessica Voight
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  5. Agustin P. Dalmasso
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Corresponding author

Correspondence to Richard W. Bianco .

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Editors and Affiliations

  1. Dept. Surgery, University of Minnesota, Delaware St. SE., 420, Minneapolis, 55455, U.S.A.

    Paul A. Iaizzo

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Bianco, R.W., Gallegos, R.P., Rivard, A.L., Voight, J., Dalmasso, A.P. (2009). Animal Models for Cardiac Research. In: Iaizzo, P. (eds) Handbook of Cardiac Anatomy, Physiology, and Devices. Humana Press. https://doi.org/10.1007/978-1-60327-372-5_25

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  • DOI: https://doi.org/10.1007/978-1-60327-372-5_25

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