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Handbook of Cardiac Anatomy, Physiology, and Devices pp 297–317Cite as

Energy Metabolism in the Normal and Diseased Heart

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Abstract

This chapter reviews the metabolic pathways involved in transferring the chemical energy stored in dietary carbon substrates (primarily glucose and fatty acids) into adenosine triphosphate (ATP) and the regulatory systems that integrate the functions of these pathways and make them responsive to changes in energy demand. Normal cardiac function depends upon both the adequate delivery of carbon substrates and oxygen to the heart by the coronary circulation and the ability of the heart to extract and metabolize these substrates at rates sufficient to support a wide range of ATP demands. The effects of several physiological states and disease processes on cardiac metabolism are also discussed and the concept that the diseased heart may be energy limited is presented. Lastly, an example of a new therapeutic approach, based on a detailed understanding of an inherited metabolic pathway abnormality, emphasizes the importance of detailed knowledge of energetic pathways.

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Notes

  1. 1.

    This work was supported by NIH grants HL33600, HL58840, HL20598, and HL21872 and Veterans Administration medical research funds.

General References and Suggested Reading

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Authors and Affiliations

  1. University of Minnesota, Cardiovascular Division, Center for Magnetic Resonance Research, 2021 6th St. SE, Minneapolis, MN, 55455, USA

    Arthur H. L. From & Robert J. Bache

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  1. Arthur H. L. From
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  2. Robert J. Bache
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Correspondence to Arthur H. L. From .

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Editors and Affiliations

  1. Dept. Surgery, University of Minnesota, Delaware St. SE., 420, Minneapolis, 55455, U.S.A.

    Paul A. Iaizzo

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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From, A.H.L., Bache, R.J. (2009). Energy Metabolism in the Normal and Diseased Heart. In: Iaizzo, P. (eds) Handbook of Cardiac Anatomy, Physiology, and Devices. Humana Press. https://doi.org/10.1007/978-1-60327-372-5_19

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  • DOI: https://doi.org/10.1007/978-1-60327-372-5_19

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-371-8

  • Online ISBN: 978-1-60327-372-5

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