Abstract
Given the prevalence and impact of hypertension on vascular disease in diabetic patients, the prevalence, awareness, treatment, and control of hypertension in diabetes has important implications for healthcare policy and professional guidelines. This report examines changes in the clinical epidemiology of hypertension in diabetes from 1988 to 2008 using the National Health and Nutrition Examination Survey database subdivided into 1988–1994, 1999–2004, and 2005–2008. Over time, prevalent hypertension, defined as blood pressure (BP) ≥140/≥90 mmHg or self-reported hypertension treatment, increased from 51 % to 66 %, p < 0.001. BP declined from 145.2/74.7 to 136.5/69.7, p < 0.001, among all patients with diabetes and hypertension. The reduction in BP reflected improvements in hypertension awareness (83–92 %, p < 0.001), treatment (73–87 %, p < 0.001), proportion of treated patients controlled (48–62 %, p < 0.01), and controlled to <140/<90 (35.5–54.6 %, p < 0.001). BP control to the more stringent target of <130/<80 rose (18–36 %, p < 0.01). The proportion of patients with diabetes and hypertension who had normal BP (<120/<80) increased from 10.7 % to 20.8 %, whereas the proportion with Stage 2 hypertension (BP ≥160/≥100) decreased from 23.5 % to 14.5 % (both p < 0.001). Hypertension control improved, although body mass index increased from 31.3 to 33.1 kg/m2, p < 0.001, and likely reflected a decrease in hypertension treated with 0–1 and an increase in treatment with ≥3 antihypertensive medications. Time trends in the clinical epidemiology of hypertension among patients with diabetes are positive, except for prevalence, and parallel findings reported in all patients with hypertension over the same time period.
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References
Salanitro AH, Roimie CL. Blood pressure management in patients with diabetes. Clin Diab. 2010;26:107–14.
Keenan NL, Rosendorf KA. Prevalence of hypertension and controlled hypertension—United States, 2005–2008. MMWR. 2011;60:94–7.
Kannel WB, McGee DL. Diabetes and cardiovascular disease. J Am Med Assoc. 1979;241:2035–8.
Turner RC, Millns H, Neil HAW, Stratton IM, Manley SE, Matthews DR, et al. Risk factors for coronary heart disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23). Br Med J. 1998;316:823–8.
Wilson PWF, D’Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–47.
Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension. 2001;37:1053–9.
Wannamethee SG, Shaper AG, Whincup PH, Lennon L, Satar N. Impact of diabetes on cardiovascular disease risk and all-cause mortality in older men. Arch Intern Med. 2011;171:404–10.
Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, Toto R, et al. Preserving renal function in adults with hypertension and diabetes: a concensus approach. National Kidney Foundation Hypertension and Diabetes Executive Committee Working Group. Am J Kidney Dis. 2000;36:646–61.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206–52.
American Diabetes Association. Standards of medical care in diabetes–2011. Diab Care. 2011;34 Suppl 1:S11–61.
Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000. J Am Med Assoc. 2003;290:199–206.
Ong KL, Cheung BMY, Man YB, Lau CP, Lam KSL. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004. Hypertension. 2007;49: 69–75.
Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. J Am Med Assoc. 2010;303:2043–50.
The Accord Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362:1575–85.
Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC. Uncontrolled and apparent treatment resistant hypertension in the U.S. 1988–2008. Circulation. 2011;124:1046–1058.
National Center for Health Statistics. Analytic and reporting guidelines: the Third National Health and Nutrition Examination Survey, NHANES III (1988–94). http://www.cdc.gov/nchs/data/nhanes/nhanes3/nh3gui.pdf. Accessed 29 July 2011.
The National Center for Health Statistics. Analytic and reporting guidelines: the National Health and Nutrition Examination Survey. http://www.cdc.gov/nchs/data/ nhanes/nhanes_03_04/nhanes_analytic _guidelines_dec_2005.pdf. Accessed 29 July 2010.
Tuomilehto J, Rastenyte D, Birkenhäger WH, Thijs L, Antikainen J, Bulpitt CJ, et al. Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. Systolic hypertension in Europe trial investigators. N Engl J Med. 1999;340:677–84.
Hansson L, Zanchetti A, Carruthers SG, Dahlöf B, Elmfeldt D, Julius S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the hypertension optimal treatment (HOT) randomised trial. HOT study group. Lancet. 1998;13(351):1755–62.
UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br Med J. 1998;317: 703–13.
Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008;51:1403–19.
Quinn RR, Hemmelgarn BR, Padwal RS, Myers MG, Cloutier L, Bolli P, et al. The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I—blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol. 2010;26:241–8.
National Center for Quality Assurance HEDIS®. Technical specifications for physician measurement. Compr diabetes care. 2011;pp. 154–166.
https://www.cms.gov/PQRS/15_MeasuresCodes.asp. Accessed 5 Aug 2011.
Mellen PB, Gao SK, Vitolins MZ, Goff DC. Deteriorating dietary habits among adults with hypertension. Arch Intern Med. 2008;168:308–14.
Ford ES, Zhao G, Li C, Pearson WS, Mokdad AH. Trends in obesity and abdominal obesity among hypertensive and nonhypertensive adults in the United States. Am J Hypertens. 2008;21:1124–8.
Okonofua EC, Simpson K, Jesri A, Rehman S, Durkalski V, Egan BM. Therapeutic inertia is an impediment to achieving the Healthy People 2010 blood pressure control goals. Hypertension. 2006;47:1–7.
Egan BM, Laken MA. Is BP control to <140/<90 mmHg in 50% of all hypertensive patients as good as we can do in the United States? Or is this as good as it gets? Curr Opin Cardiol. 2011;26:356–61.
de la Sierra A, Segura J, Banegas JR, Gorostidi M, de la Cruz JJ, Armario P, et al. Clinical features of 8295 patients with resistant hypertension classified on the basis of ambulatory blood pressure monitoring. Hypertension. 2011;57:898–902.
Pimenta E, Calhoun DA. Resistant hypertension and aldosteronism. Curr Hypertens Rep. 2007;9:353–9.
Taler SJ, Textor SC, Augustine JE. Resistant hypertension: comparing hemodynamic management to specialist care. Hypertension. 2002;39:982–8.
Egan BM, Basile JN, Rehman SU, Strange P, Grob C, Riehle J, et al. Renin-guided algorithm matches clinical hypertension specialist care in uncontrolled hypertension: A randomized-controlled clinical trial. Am J Hypertens. 2009;22:792–801.
Mann SJ. Drug therapy for resistant hypertension: simplifying the approach. J Clin Hypertens. 2011;13:120–30.
Symplicity HTN–2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (the simplicity HTN-2 trial): a randomized controlled trial. Lancet. 2010;376:1903–9.
Wustmann K, Kucera JP, Scheffers I, Mohaupt M, Kroon AA, Leeuw PW, et al. Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension. 2009;54:530–6.
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Egan, B.M., Zhao, Y., Brzezinski, W.A. (2012). Epidemiology of Hypertension in Diabetes. In: McFarlane, S., Bakris, G. (eds) Diabetes and Hypertension. Contemporary Diabetes. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-357-2_1
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DOI: https://doi.org/10.1007/978-1-60327-357-2_1
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