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Caffeine, Sleep, and Quality of Life

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Sleep and Quality of Life in Clinical Medicine

Summary

Caffeine is regarded as a mild stimulant acting on the central nervous system that is responsible for a significant portion of the behavioural and physiological effects of coffee and tea. Motives why people take caffeine are reflected in consumption patterns. Early in the morning caffeine might help to wake up, whereas during the day it is an aid to stay awake or counteract fatigue. The intake of caffeine shortly before sleep might affect sleep characteristics, especially if high doses of caffeine are used. Moreover, these disturbances of sleep might result in tiredness in the morning. Caffeine is frequently used as a countermeasure for fatigue and sleepiness. During sub-optimal circumstances such as working night shifts and sleep deprivation it maintains performance and wakefulness at satisfying levels. These effects of caffeine depend largely on its antagonistic actions on the A_2A adenosine receptor. Simple task performance seems in particular sensitive to caffeine. Part of the caffeine effects might be due to withdrawal reversal, although caffeine is stimulating in non-withdrawn subjects, as well. In addition, in habitual users, there is no complete tolerance to the effects of caffeine.

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References

  1. Bruce M, Scott N, Lader M, Marks V. The psychopharmacological and electrophysiological effects of single doses of caffeine in healthy human subjects. British Journal of Clinical Pharmacology 1986;22:81–87.

    PubMed  CAS  Google Scholar 

  2. Gevins A, Smith ME, McEvoy LK. Tracking the cognitive pharmacodynamics of psychoactive substances with combinations of behavioral and neurophysiological measures. Neuropsychopharmacology 2002;26:27–39.

    Article  PubMed  CAS  Google Scholar 

  3. Lieberman HR. The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutrition Reviews 2001;59:91–102.

    Article  PubMed  CAS  Google Scholar 

  4. Smith A, Sutherland D, Christopher G. Effects of repeated doses of caffeine on mood and performance of alert and fatigued volunteers. Journal of Psychopharmacology 2005;19:620–626.

    Article  PubMed  CAS  Google Scholar 

  5. Yu G, Maskray V, Jackson SH, Swift CG, Tiplady B. A comparison of the central nervous system effects of caffeine and theophylline in elderly subjects. British Journal of Clinical Pharmacology 1991;32:341–345.

    PubMed  CAS  Google Scholar 

  6. Zwyghuizen-Doorenbos A, Roehrs TA, Lipschutz L, Timms V, Roth T. Effects of caffeine on alertness. Psychopharmacology 1990;100:36–39.

    Article  PubMed  CAS  Google Scholar 

  7. Garattini S. Caffeine, Coffee and Health. New York: Raven Press; 1993.

    Google Scholar 

  8. Gupta BS, Gupta U. Caffeine and Behaviour: Current Views and Research Trends. Boca Raton, Florida: CRC Press LCC; 1999.

    Google Scholar 

  9. Nehlig A. Coffee, Tea, Chocolate, and the Brain. Boca Raton, Florida: CRC Press LCC; 2004.

    Google Scholar 

  10. Snel J, Lorist MM. Nicotine, Caffeine and Social Drinking: Behaviour and Brain Function. The Netherlands: Harwood Academic Publishers; 1998.

    Google Scholar 

  11. Arnaud MJ. Pharmacokinetics and metabolism of caffeine. In: Snel J, Lorist MM, editors. Nicotine, Caffeine and Social Drinking: Behaviour and brain function. The Netherlands: Harwood Academic Publishers; 1998: p. 153–165.

    Google Scholar 

  12. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological Reviews 1999;51:83–133.

    PubMed  CAS  Google Scholar 

  13. Satel S. Is caffeine addictive? - A review of the literature. American Journal of Drug and Alcohol Abuse 2006;32:493–502.

    Article  PubMed  Google Scholar 

  14. Daly JW. Mechanisms of action of caffeine. In: Garattini S, editor. Caffeine, Coffee and Health. New York: Raven Press; 1993: p. 97–150.

    Google Scholar 

  15. Daly JW, Fredholm BB. In: Nehlig A, editor. Coffee, Tea, Chocolate, and the Brain. Boca Raton, Florida: CRC Press LCC; 2004. p. 1–11.

    Google Scholar 

  16. Kalinchuk AV, Urrila AS, Alanko L, Heiskanen S, Wigren HK, Suomela M, Stenberg D, Porkka-Heiskanen T. Local energy depletion in the basal forebrain increases sleep. The European Journal of Neuroscience 2003;17:863–869.

    Article  PubMed  Google Scholar 

  17. Porkka-Heiskanen T, Strecker RE, Thakkar M, Bjorkum AA. Adenosine: A mediator of the sleep-inducing effects of prolonged wakefulness. Science 1997;276:1265–1267.

    Article  PubMed  CAS  Google Scholar 

  18. Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, et al. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nature Neuroscience 2005;8:858–859.

    PubMed  CAS  Google Scholar 

  19. Bättig K. Coffee, cardiovascular and behavioral effects current research trends. Reviews on Environmental Health 1991;9:53–84.

    PubMed  Google Scholar 

  20. Brice CF, Smith AP. Factors associated with caffeine consumption. International Journal of Food Sciences and Nutrition 2002;53:55–64.

    PubMed  Google Scholar 

  21. Shohet KL, Landrum RE. Caffeine consumption questionnaire: a standardized measure for caffeine consumption in undergraduate students. Psychological Reports 2001;89:521–526.

    Article  PubMed  CAS  Google Scholar 

  22. Lane JD. Neuroendocrine responses to caffeine in the work environment. Psychosomatic Medicine 1994;56:267–270.

    PubMed  CAS  Google Scholar 

  23. Mitler MM, Carskadon MA, Czeisler CA, Dement WC, Dinges DF, Graeber RC. Catastrophes, sleep, and public-policy - Consensus Report. Sleep 1988;11:100–109.

    PubMed  CAS  Google Scholar 

  24. Garbarino S, Nobili L, Beelke M, De Carli F, Ferrillo F. The contributing role of sleepiness in highway vehicle accidents. Sleep 2001;24:203–6.

    PubMed  CAS  Google Scholar 

  25. Smith AP. Effects of caffeine on attention: Low levels of arousal. In: Snel J, Lorist MM, editors. Nicotine, Caffeine and Social Drinking: Behaviour and Brain Function. The Netherlands: Harwood Academic Publishers; 1998: p. 215–227.

    Google Scholar 

  26. Hayashi M, Masuda A, Hori T. The alerting effects of caffeine, bright light and face washing after a short daytime nap. Clinical Neurophysiology 2003;114:2268–2278.

    Article  PubMed  CAS  Google Scholar 

  27. Snel J. Coffee and caffeine: sleep and wakefulness. In: Garattini S, editor. Caffeine, Coffee and Health. New York: Raven Press; 1993. p. 255–290.

    Google Scholar 

  28. Drapeau C, Hamel-Hébert I, Robillard R, Selmaoui B, Filipini D, Carrier J. Challenging sleep in aging: The effects of 200 mg of caffeine during the evening in young and middle-aged moderate caffeine consumers. Journal of Sleep Research 2006;15:133–141.

    Article  PubMed  Google Scholar 

  29. Alford C, Bhatti J, Leigh T, Jamieson A. Caffeine-induced sleep disruption: Effects on waking the following day and its reversal with an hypnotic. Human Psychopharmacology: Clinical and Experimental 1996;11:185–198.

    Article  CAS  Google Scholar 

  30. Akerstedt T, Ficca G. Alertness-enhancing drugs as a countermeasure to fatigue in irregular work hours. Chronobiology International 1997;14:145–158.

    PubMed  CAS  Google Scholar 

  31. Orbeta RL, Overpeck MD, Ramcharran D, Kogan MD, Ledsky R. High caffeine intake in adolescents: Associations with difficulty sleeping and feeling tired in the morning. Journal of Adolescent Health 2006;38:451–453.

    Article  PubMed  Google Scholar 

  32. Bernstein GA, Carroll ME, Thuras PD, Cosgrove KP, Roth ME. Caffeine dependence in teenagers. Drug and Alcohol Dependence 2002;66:1–6.

    Article  PubMed  Google Scholar 

  33. NAH. Caffeine: the inside scoop - the good, the bad, and the myth. Nutrition Action Health Letter 1996. Available from: www.cspinet.org/nah/good bad.htm

    Google Scholar 

  34. Anderson C, Horne JA. A high sugar content, low caffeine drink does not alleviate sleepiness but may worsen it. Human Psychopharmacology: Clinical and Experimental 2006;21:299–303.

    Article  CAS  Google Scholar 

  35. Basner RC. Shift-work sleep disorder–the glass is more than half empty. The New England Journal of Medicine 2005;353:519–521.

    Article  PubMed  CAS  Google Scholar 

  36. Torsvall L, Akerstedt T, Gillander K, Knutsson A. Sleep on the night shift: 24-hour EEG monitoring of spontaneous sleep/wake behavior. Psychophysiology 1989;26:352–358.

    Article  PubMed  CAS  Google Scholar 

  37. Gillooly PB, Smolensky MH, Albright DL, Hsi B, Thorne DR. Circadian variation in human performance evaluated by the Walter Reed performance assessment battery. Chronobiology International 1990;7:143–153.

    Article  PubMed  CAS  Google Scholar 

  38. Folkard S, Tucker P. Shift work, safety and productivity. Occupational Medicine 2003;53:95–101.

    Article  PubMed  Google Scholar 

  39. Connor J, Norton R, Ameratunga S, Robinson E, Civil I, Dunn R, et al. Driver sleepiness and risk of serious injury to car occupants: population based case control study. British Medical Journal 2002;324:1125.

    Article  PubMed  Google Scholar 

  40. Personick M, Mushinski M. Highway fatalities: leading cause of work-related deaths. Statistical Bulletin (Metropolitan Life Insurance Company: 1984) 1997;78:19–25.

    CAS  Google Scholar 

  41. Wright KP, Jr., Myers BL, Plenzler SC, Drake CL, Badia P. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Research 2000;873:310–317.

    Article  PubMed  CAS  Google Scholar 

  42. Wright KP, Jr., Badia P, Myers BL, Plenzler SC. Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. Journal of Sleep Research 1997;6:26–35.

    Article  PubMed  Google Scholar 

  43. Wright KP, Jr., Badia P, Myers BL, Plenzler SC, Hakel M. Caffeine and light effects on night time melatonin and temperature levels in sleep-deprived humans. Brain Research 1997;747:78–84.

    Article  PubMed  CAS  Google Scholar 

  44. Shilo L, Sabbah H, Hadari R, Kovatz S, Weinberg U, Dolev S, et al. The effects of coffee consumption on sleep and melatonin secretion. Sleep Medicine 2002;3:271–273.

    Article  PubMed  Google Scholar 

  45. Babkoff H, French J, Whitmore J, Sutherlin R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviation Space and Environmental Medicine 2002;73:341–350.

    CAS  Google Scholar 

  46. Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Frontiers in Neuroendocrinology 2004;25:177–195.

    Article  PubMed  CAS  Google Scholar 

  47. Landolt HP, Dijk DJ, Gaus SE, Borbély AA. Caffeine reduces low-frequency delta activity in the human sleep EEG. Neuropsychopharmacology 1995;12:229–238.

    Article  PubMed  CAS  Google Scholar 

  48. Landolt HP, Werth E, Borbély AA, Dijk DJ. Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night. Brain Research 1995;675:67–74.

    Article  PubMed  CAS  Google Scholar 

  49. Landolt HP, Rétey JV, Tönz K, Gottselig JM, Khatami R, Buckelmüller I, Achermann P. Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology 2004;29:1933–1939.

    Article  PubMed  CAS  Google Scholar 

  50. Wyatt JK, Cajochen C, Cecco AR-D, Czeisler CA, Dijk DJ. Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulness. Sleep 2004;27:374–381.

    PubMed  Google Scholar 

  51. Rosa RR. Napping at home and alertness on the job in rotating shift workers. Sleep 1993;16:727–735.

    PubMed  CAS  Google Scholar 

  52. Bonnet MH, Arand DL. Impact of naps and caffeine on extended nocturnal performance. Physiology and Behavior 1994;56:103–109.

    Article  PubMed  CAS  Google Scholar 

  53. Philip P, Taillard J, Moore N, Delord S, Valtat C, Sagaspe P, Bioulac B. The effects of coffee and napping on nighttime highway driving: a randomized trial. Annals of Internal Medicine 2006;144:785–791.

    PubMed  Google Scholar 

  54. Schweitzer PK, Randazzo AC, Stone K, Erman M, Walsh JK. Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work. Sleep 2006;29:39–50.

    PubMed  Google Scholar 

  55. Wesensten NJ, Killgore WDS, Balkin TJ. Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation. Journal of Sleep Research 2005;14(3):255–266.

    Article  PubMed  Google Scholar 

  56. Salín-Pascual RJ, Valencia-Flores M, Campos RM, Castaño A, Shiromani PJ. Caffeine challenge in insomniac patients after total sleep deprivation. Sleep Medicine 2006;7:141–145.

    Article  PubMed  Google Scholar 

  57. Reilly T, Waterhouse J, Edwards B. Jet lag and air travel: Implications for performance. Clinics in Sports Medicine 2005;24: 367–380.

    Article  PubMed  Google Scholar 

  58. Beaumont M, Batéjat D, Piérard C, Van BP, Denis JB, Coste O, Doireau P, Chauffard F, French J, Lagarde D. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. Journal of Applied Physiology 2004;96:50–58.

    Article  PubMed  CAS  Google Scholar 

  59. Weiss B, Laties VG. Enhancement of human performance by caffeine and the amphetamines. Pharmacological Review 1962;14:1–36.

    CAS  Google Scholar 

  60. Lorist MM, Snel J, Kok A. Influence of caffeine on information processing stages in well rested and fatigued subjects. Psychopharmacology 1994;113:411–421.

    Article  PubMed  CAS  Google Scholar 

  61. Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R, et al. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. Journal of Sleep Research 2000;9:335–352.

    Google Scholar 

  62. Bonnet MH, Gomez S, Wirth O, Arand DL. The use of caffeine versus prophylactic naps in sustained performance. Sleep 1995;18:97–104.

    PubMed  CAS  Google Scholar 

  63. Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R. Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U. S. Navy SEAL training. Psychopharmacology 2002;164:250–261.

    Article  PubMed  CAS  Google Scholar 

  64. Gottselig JM, Adam M, Rétey JV, Katami R, Achermann P, Landolt HP. Random number generation during sleep deprivation: Effects of caffeine on response maintenance and stereotypy. Journal of Sleep Research 2006;15:31–40.

    Article  PubMed  Google Scholar 

  65. Kohler M, Pavy A, Van den Heuvel C. The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation. Journal of Sleep Research 2006;15:358–368.

    Article  PubMed  Google Scholar 

  66. Killgore WDS, McBride SA, Killgore DB, Balkin TJ. The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation. Sleep 2006;29:841–847.

    PubMed  Google Scholar 

  67. Reyner LA, Horne JA. Early morning driver sleepiness: Effectiveness of 200 mg caffeine. Psychophysiology 2000;37:251–256.

    Article  PubMed  CAS  Google Scholar 

  68. Dagan Y, Doljansky JT. Cognitive performance during sustained wakefulness: a low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. Chronobiology International 2006;23:973–983.

    Article  PubMed  CAS  Google Scholar 

  69. Wesensten NJ, Belenky G, Kautz MA, Thorne DR, Reichardt RM, Balkin TJ. Maintaining alertness and performance during sleep deprivation: Modafinil versus caffeine. Psychopharmacology 2002;159:238–247.

    Article  PubMed  CAS  Google Scholar 

  70. Wesensten NJ, Belenky G, Thorne DR, Kautz MA, Balkin TJ. Modafinil vs. caffeine: Effects on fatigue during sleep deprivation. Aviation Space and Environmental Medicine 2004;75:520–525.

    CAS  Google Scholar 

  71. Dews PB. Caffeine: behavioral effects of withdrawal and related issues. Food and Chemical Toxicology 2002;40:1257–1261.

    Article  PubMed  CAS  Google Scholar 

  72. James JE. Does caffeine enhance or merely restore degraded psychomotor performance. Neuropsychobiology 1994;30:124–125.

    Article  PubMed  CAS  Google Scholar 

  73. Rogers PJ, Dernoncourt C. Regular caffeine consumption: A balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacology Biochemistry and Behavior 1998;59:1039–1045.

    Article  CAS  Google Scholar 

  74. Rogers PJ, Heatherley SV, Hayward RC, Seers HE, Hill J, Kane M. Effects of caffeine and caffeine withdrawal on mood and cognitive performance degraded by sleep restriction. Psychopharmacology 2005;179:742–752.

    Article  PubMed  CAS  Google Scholar 

  75. James JE, Gregg ME. Effects of dietary caffeine on mood when rested and sleep restricted. Human Psychopharmacology: Clinical and Experimental 2004;19:333–41.

    Article  CAS  Google Scholar 

  76. Attwood AS, Terry P, Higgs S. Exploring factors that mediate responsiveness to caffeine. Appetite 2006;47:258.

    Google Scholar 

  77. Johnson LC, Spinweber CL, Gomez SA. Benzodiazepines and caffeine: effect on daytime sleepiness, performance, and mood. Psychopharmacology 1990;101:160–167.

    Article  PubMed  CAS  Google Scholar 

  78. Hewlett P, Smith A. Acute effects of caffeine in volunteers with different patterns of regular consumption. Human Psychopharmacology 2006;21:167–180.

    Article  PubMed  CAS  Google Scholar 

  79. Haskell CF, Kennedy DO, Wesnes KA, Scholey AB. Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology 2005;179:813–825.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Experimental and Work Psychology/BCN Neuroimaging Center, Faculty of Behavioural and Social Sciences, University of Groningen, Groningen, The Netherlands

    Monicque M. Lorist & Jan Snel

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  1. Monicque M. Lorist
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  2. Jan Snel
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Editors and Affiliations

  1. Section Psychopharmacology Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508TB, PoBox 80082, Utrecht, The Netherlands

    Joris C. Verster

  2. Divison of Clinical Pharmacology and Experimental Therapeutics Department of Medicine, College of Physicians and Surgeons of Columbia University, 630 West 168th Street - Rm # BB813, New York, NY 10032, USA

    S. R. Pandi-Perumal

  3. Department of Psychiatry, Kunin-Lunenfeld Applied Research Unit (KLARU), 3560 Bathurst St., Toronto, M6A 2E1, Canada

    David L. Streiner

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Lorist, M.M., Snel, J. (2008). Caffeine, Sleep, and Quality of Life. In: Verster, J.C., Pandi-Perumal, S.R., Streiner, D.L. (eds) Sleep and Quality of Life in Clinical Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-343-5_33

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  • DOI: https://doi.org/10.1007/978-1-60327-343-5_33

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