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Nitric Oxide Biochemistry: Pathophysiology of Nitric Oxide-Mediated Protein Modifications

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Book cover Oxidative Neural Injury

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

Nitric oxide (NO) is a pluripotent signaling molecule, which has been proposed to be critically important in both physiological and pathological processes of the brain. The wide-ranging functionality of NO is in opposition to its relatively simple chemical structure. In this chapter we attempt to summarize the functional involvement of NO within the neurological system and then discuss how such complex signaling may be achieved via the differential post-translational modification of protein targets. It is our contention that the redox properties of NO allow this molecule to modify proteins in a variety of ways with physiological or pathological consequences. In this way the effects of NO production are dependent on the quantity produced, the redox environment in which it is synthesized, and the presence of reactive targets. A summary of known post-translational modifications is given as well as the functional consequences of their formation.

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  1. Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08664, USA

    Alba Rossi-George

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  1. Alba Rossi-George
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  2. Andrew Gow
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    Rossi-George, A., Gow, A. (2009). Nitric Oxide Biochemistry: Pathophysiology of Nitric Oxide-Mediated Protein Modifications. In: Veasey, S. (eds) Oxidative Neural Injury. Contemporary Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-60327-342-8_2

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