Antibodies provide much of the protection afforded by the vaccines in the current arsenal; however, only recently has an in-depth understanding emerged of the molecular basis of B-cell development, selection, and effector function that may allow more strategic manipulation of the B-cell compartment (1).
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References
Hackett, C. J., Rotrosen, D., Auchincloss, H., and Fauci, A. S. (2007) Immunology research: challenges and opportunities in a time of budgetary constraint, Nat. Immunol., 8, 114–117.
Welner, R. S., Pelayo, R., and Kincade, P. W. (2008) Evolving genealogy of B cells, Nat. Rev. Immunol., 8, 95–106.
Miyamoto, T., Iwasaki, H., Reizis, B., Ye, M., Graf, T., Weissman, I., and Akashi, K. (2002) Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment, Dev. Cell, 3, 137–147.
Mansson, R., Hultquist, A., Luc, S., et al. (2007) Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors, Immunity, 26, 407–419.
Hu, M., Krause, D., Greaves, D., et al. (1997) Multilineage gene expression precedes commitment in the hematopoietic system, Genes Dev., 11, 774–785.
Park, Y.-H. and Osmond, D. G. (1989) Dynamics of early B lymphocyte precursor cells in mouse bone marrow: proliferation of cells containing terminal deoxynucleotidyl transferase, Eur. J. Immunol., 19, 2139–2144.
Medina, K. L., Garrett, K. P., Thompson, L. F., et al. (2001) Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen, Nat. Immunol., 2, 718–724.
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., and Kincade, P. W. (2002) Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow, Immunity, 17, 117–130.
Kiel, M. J., Yilmaz, ö., Iwashita, T., Yilmaz, O., Terhorst, C., and Morrison, S. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells, Cell, 121, 1109–1121.
Hirose, J., Kouro, T., Igarashi, H., Yokota, T., Sakaguchi, N., and Kincade, P. W. (2002) A developing picture of lymphopoiesis in bone marrow, Immunol. Rev., 189, 28–40.
Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B. I., and Nagasawa, T. (2004) Cellular niches controlling B lymphocyte behaviour within bone marrow during development, Immunity, 20, 707–718.
Torlakovic, E., Tenstad, E., Funderud, S., and Rian, E. (2005) CD10+ stromal cells form B-lymphocyte maturation niches in the human bone marrow, J. Pathol., 205, 311–317.
Yao, L., Yokota, T., Xia, L., Kincade, P. W., and McEver, R. P. (2005) Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells, Blood., 106, 4093–4101.
Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., and Orkin, S. H. (2007) Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment, Cell, 129, 1081–1095.
Taniguchi, H., Toyoshima, T., Fukao, K., and Nakauchi, H. (1996) Presence of hematopoietic stem cells in the adult liver, Nat. Med., 2, 198–203.
Bhattacharya, D., Rossi, D. J., Bryder, D., and Weissman, I. L. (2006) Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning, J. Exp. Med., 203, 73–85.
Wilson, A. and Trumpp, A. (2006) Bone-marrow haematopoietic-stem-cell niches, Nat. Rev. Immunol., 6, 93–106.
Suda, T., Arai, F., and Hirao, A. (2005) Hematopoietic stem cells and their niche, Trends Immunol., 26, 426–433.
Varnum-Finney, B., Brashem-Stein, C., and Bernstein, I. D. (2003) Combined effects of Notch signalling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability, Blood, 101, 1784–1789.
Zhang, C. C. and Lodish, H. F. (2005) Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion, Blood, 105, 4314–4320.
Reya, T., Duncan, A. W., Ailles, L., et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells, Nature, 423, 409–414.
Sauvageau, G., Iscove, N. N., and Humphries, R. K. (2004) In vitro and in vivo expansion of hematopoietic stem cells, Oncogene, 23, 7223–7232.
Waskow, C., Paul, S., Haller, C., Gassmann, M., Rodewald, H. R. (2002) Viable c-KitW/W mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis, Immunity, 17, 277–288.
Mackarehtschian, K., Hardin, J. D., Moore, K. A., et al. (1995) Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors, Immunity, 3, 147–161.
Passegue, E., Wagers, A. J., Giuriato, S., Anderson, W. C., and Weissman, I. L. (2005) Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates, J. Exp. Med., 202, 1599–1611.
Cheshier, S. H., Morrison, S. J., Liao, X., and Weissman, I. L. (1999) In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells, Proc. Natl Acad. Sci. U.S.A., 96, 3120–3125.
Pelayo, R., Miyazaki, K., Huang, J., et al. (2006) Cell cycle quiescence of early lymphoid progenitors in adult bone marrow, Stem Cells, 24, 2703–2713.
Arai, F., Hirao, A., Ohmura, M., et al. (2004) Tie2/angiopoietin-1 signalling regulates hematopoietic stem cell quiescence in the bone marrow niche, Cell, 118, 149–161.
Zhang, C. C., Kaba, M., Ge, G., et al. (2006) Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells, Nat. Med., 12, 240–245.
Stier, S., Ko, Y., Forkert, R., et al. (2005) Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size, J. Exp. Med., 201, 1781–1791.
Maeda, K., Baba, Y., Nagai, Y., et al. (2005) IL-6 blocks a discrete early step in lymphopoiesis, Blood, 106, 879–885.
Nakamura, K., Kouro, T., Kincade, P. W., et al. (2004) Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow, J. Exp. Med. 199, 243–254.
Kouro, T., Medina, K. L., Oritani, K., and Kincade, P. W. (2001) Characteristics of early murine B lymphocyte precursors and their direct sensitivity to negative regulators, Blood, 97, 2708–2715.
North, T. E., Goessling, W., Walkley, C. R., et al. (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis, Nature, 447, 1007–1011.
Kincade, P. W., Igarashi, H., Medina, K. L., et al. (2002) Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage, Semin. Immunol., 14, 385–394.
Koch, U., Wilson, A., Cobas, M., et al. (2007) Simultaneous loss of β- and γ-catenin does not perturb hematopoiesis or lymphopoiesis, Blood, 111(1), 160–164.
Nemeth, M. J., Topol, L., Anderson, S. M., Yang, Y., and Bodine, D. M. (2007) Wnt5a inhibits canonical Wnt signalling in hematopoietic stem cells and enhances repopulation, Proc. Natl. Acad. Sci. U.S.A., 104, 15436–15441.
Jeannet, G., Scheller, M., Scarpellino, L., et al. (2007) Long-term, multilineage hematopoiesis occurs in the combined absence of β-catenin and γ-catenin, Blood, 111(1), 142–149.
Baba, Y., Garrett, K. P., and Kincade, P. W. (2005) Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors, Immunity, 23, 599–609.
Baba, Y., Yokota, T., Spits, H., et al. (2006) Constitutively active β-catenin promotes expansion of multipotent hematopoietic progenitors in culture, J. Immunol., 177, 2294–2303.
Liang, H., Chen, Q., Coles, A., et al. (2003) Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue, Cancer Cell, 4, 349–360.
Kondo, M., Weissman, I. L., and Akashi, K. (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, 91, 661–672.
Kondo, M., Weissman, I. L., and Akashi, K. (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, 91, 661–672.
Perry, S. S., Wang, H., Pierce, L. J., et al. (2004) L-selectin defines a bone marrow analogue to the thymic early T-cell-lineage progenitor, Blood, 103, 2990–2996.
Kondo, M., Weissman, I. L., and Akashi, K. (1997) Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell, 91, 661–672.
Bhandoola, A., Von Boehmer, H., Petrie, H. T., and Zúñiga-Pflücker, J. C. (2007) Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from, Immunity, 26, 678–689.
Allman, D., Sambandam, A., Kim, S., et al. (2003) Thymopoiesis independent of common lymphoid progenitors, Nat. Immunol., 4, 168–174.
Huang, J., Garrett, K. P., Pelayo, R., et al. (2005) Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation, J. Immunol., 175, 4858–4865.
Nagai, Y., Garrett, K., Ohta, S., et al. (2006) Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment, Immunity, 24, 801–812.
Treml, L. S., Crowley, J. E., and Cancro, M. P. (2006) BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen- experienced B cells, Semin. Immunol., 18(5), 297–304.
Ruprecht, C. R. and Lanzavecchia, A. (2006) Toll-like receptor stimulation as a third signal required for activation of human naive B cells, Eur. J. Immunol., 36(4), 810–816.
Bossen, C. and Schneider, P. (2006) BAFF, APRIL and their receptors: structure, function and signaling, Semin. Immunol., 18(5), 263–275.
Woodland, R. T., Schmidt, M. R., and Thompson, C. B. (2006) BLyS and B cell homeostasis, Semin. Immunol., 18(6), 318–326.
Do, R. K. and Chen-Kiang, S. (2002) Mechanism of BLyS action and B cell immunity, Cytokine Growth Factor Revs., 13(1), 19–25.
Baker, K. P. (2004) BLyS – an essentilal survival factor for B cells: basic biology, links to pathology and therapeutic target, Autoimmune Revs., 3(5), 368–375.
Marsters, S. A., Yan, M., Pitti, R. M., Haas, P. E., Dixit, V. M., and Ashkenazi, A. (2000) Interaction of the TNF homoIogues BLyS and APRIL with the TNF receptor homologues BCMA and TACI, Curr. Biol., 10(13), 785–788.
Crowley, J. E., Treml, L. S., Stadanlick, J. E., Carpenter, E., and Cancro, M. P. (2005) Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands, Semin. Immunol., 17(3), 193–199.
Yan, M., Ridgway, J., Chan, B., et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency, Curr. Biol., 11(19), 1547–1552.
Locksley, R. M., Killeen, N., and Lenardo, M. J. (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology, Cell, 104, 487–501.
Ware, C. F. (2000) APRIL and BAFF connect autoimmunity and cancer, J. Exp. Med., 192, F3–F38.
Ambrose, C. M. (2002) Baff-R, J. Biol. Regul. Homeost. Agents, 16, 211–213.
Kalled, S. L. (2002) BAFF: a novel therapeutic target for autoimmunity, Curr. Opin. Investig. Drugs, 3, 1005–1010.
Mackay , F. and Browning, J. L. (2002) BAFF: a fundamental survival factor for B cells, Nat. Rev. Immunol., 2, 465–475.
Nardelli, B., Moore, P. A., Li, Y., and Hilbert, D. M. (2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases, Leuk. Lymphoma., 43, 1367–1373.
Stohl, B. (2002) B lymphocyte stimulator protein levels in systemic lupus erythematosus and other diseases, Curr. Rheumatol. Rep., 4, 345–350.
Cancro, M. P. and Smith, S. H. (2003) Peripheral B cell selection and homeostasis, Immunol Res., 27, 141–148.
Carter, R. H. (2003) A role for BLyS in tissue inflammation? Arthritis Rheum., 48, 882–885.
Smith, S. H. and Cancro, M. P. (2003) BLyS: the pivotal determinant of peripheral B cell selection and lifespan, Curr. Pharm. Des., 9, 1833–1847.
Smith, S. H. and Cancro, M. P. (2003) Integrating B cell homeostasis and selection with BLyS, Arch. Immunol. Ther. Exp. (Warsz), 51, 209–218.
Mackay, F. and Ambrose, C. (2003) The TNF family members BAFF and APRIL: the growing complexity, Cytokine Growth Factor Rev., 14, 311–324.
Medema, J. P., Planelles-Carazo, L., Hardenberg, G., and Hahne, M. (2003) The uncertain glory of APRIL, Cell Death Differ., 10, 1121–1125.
Schneider, P. and Tschopp, J. (2003) BAFF and the regulation of B cell survival, Immunol. Lett., 88, 57–62.
Cancro, M. P. (2004) The BLyS family of ligands and receptors: an archetype for niche-specific homeostatic regulation, Immunol. Rev., 202, 237–249.
Cancro, M. P. (2004) Peripheral B-cell maturation: the intersection of selection and homeostasis, Immunol. Rev., 197, 89–101.
Mackay, F. and Tangye, S. G. (2004) The role of the BAFF/APRIL system in B cell homeostasis and lymphoid cancers, Curr. Opin. Pharmacol., 4, 347–354.
Stohl, W. (2004) Targeting B lymphocyte stimulator in systemic lupus erythematosus and other autoimmune rheumatic disorders, Expert Opin. Ther. Targets, 8, 177–189.
Jelinek, D. F. and Darce, J. R. (2005) Human B lymphocyte malignancies: exploitation of BLyS and APRIL and their receptors, Curr. Dir. Autoimmun., 8, 266–288.
Kalled, S. L. (2005) The role of BAFF in immune function and implications for autoimmunity, Immunol Rev., 204, 43–54.
Mackay, F., Sierro, F., Grey, S. T. and Gordon, T. P. (2005) The BAFF/APRIL system: an important player in systemic rheumatic diseases, Curr. Dir. Autoimmun., 8, 243–265.
Noelle, R. J. and Erickson, L. D. (2005) Determinations of B cell fate in immunity and autoimmunity, Curr. Dir. Autoimmun., 8, 1–24.
Salzer, U. and Grimbacher, B. (2005) TACItly changing tunes: farewell to a yin and yang of BAFF receptor and TACI in humoral immunity? New genetic defects in common variable immunodeficiency, Curr. Opin. Allergy Clin. Immunol., 5, 496–503.
Schneider, P. (2005) The role of APRIL and BAFF in lymphocyte activation, Curr. Opin. Immunol., 17, 282–289.
Stohl, W. (2005) BlySfulness does not equal blissfulness in systemic lupus erythematosus: a therapeutic role for BLyS antagonists, Curr. Dir. Autoimmun., 8, 289–304.
Szodoray, P. and Jonsson, R. (2005) The BAFF/APRIL system in systemic autoimmune diseases with a special emphasis on Sjogren’s syndrome, Scand. J. Immunol., 62, 421–428.
Moore, P. A., Belvedere, O., Orr, A., et al. (1999) BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator, Science, 285, 260–263.
Mukhopadhyay, A., Ni, J., Zhai, Y., Yu, G. L., and Aggarwal, B. B. (1999) Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase, J. Biol. Chem., 274, 15978–15981.
Shu, H. B., Hu, W. H., and Johnson, H. (1999) TALL-1 is a novel member of the TNF family that is down-regulated by mitogens, J. Leukoc. Biol., 65, 680–683.
Schneider, P., MacKay, F., Steiner, V., et al. (1999) BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth, J. Exp. Med., 189, 1747–1756.
Kelly, K., Manos, E., Jensen, G., Nadauld, L., and Jones, D. A. (2000) APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death, Cancer Res., 60, 1021–1027.
Lopez-Fraga, M., Fernandez, R., Albar, J. P., and Hahne, M. (2001) Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase, EMBO Rep., 2, 945–951.
Bossen, C., Ingold, K., Tardivel, A., et al. (2006) Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human, J. Biol. Chem., 281, 13964–13971.
Gavin, A. L., Duong, B., Skog, P., et al. (2005) DeltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in vivo in transgenic mouse models, J. Immunol., 175, 319–328.
Gavin, A. L., Ait-Azzouzene, D., Ware, C. F., and Nemazee, D. (2003) DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF, J. Biol. Chem., 278, 38220–38228.
Roschke, V., Sosnovtseva, S., Ward, C. D., et al. (2002) BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases, J. Immunol., 169, 4314–4321.
Yan, M., Marsters, S. A., Grewal, N., Wang, H., Ashkenazi, A., and Dixit, V. M. (2000) Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity, Nat. Immunol., 1, 37–41.
Moreaux, J., Cremer, F. W., Reme, T., et al. (2005) The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature, Blood, 106(3), 1021–1030.
Yan, M., Brady, J. R., Chan, B., et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency, Curr. Biol., 11, 1547–1552.
Schiemann, B., Gommerman, J. L., Vora, K., et al. (2001) An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway, Science, 293, 2111–2114.
Hahne, M., Kataoka, T., Schroter, M., et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth, J. Exp. Med., 188, 1185–1190.
Hymowitz, S. G., Patel, D. R., Wallweber, H. J., et al. (2005) Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding, J. Biol. Chem., 280, 7218–7227.
von Bulow, G. U. and Bram, R. J. (1997) NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily, Science, 278, 138–141.
Day, E. S., Cachero, T. G., Qian, F., et al. (2005) Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA, Biochemistry, 44, 1919–1931.
Patel, D. R., Wallweber, H. J., Yin, J., et al. (2004) Engineering an APRIL-specific B cell maturation antigen, J. Biol. Chem., 279, 16727–16735.
Pelletier, M., Thompson, J. S., Qian, F., et al. (2003) Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF, J. Biol. Chem., 278, 33127–33133.
Wu, Y., Bressette, D., Carrell, J. A., et al. (2000) Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS, J. Biol. Chem., 275, 35478–35485.
Ingold, K., Zumsteg, A., Tardivel, A., et al. (2005) Identification of proteoglycans as the APRIL-specific binding partners, J. Exp. Med., 201, 1375–1383.
Xia, X. Z., Treanor, J., Senaldi, G., et al. (2000) TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation, J. Exp. Med., 192, 137–143.
Hatzoglou, A., Roussel, J., Bourgeade, M. F., et al. (2000) TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase, J. Immunol., 165, 1322–1330.
Claudio, E., Brown, K., Park, S., Wang, H., and Siebenlist, U. (2002) BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells, Nat. Immunol., 3, 958–965.
Kayagaki, N., Yan, M., Seshasayee, D., et al. (2002) BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2, Immunity, 17, 515–524.
Gordon, N. C., Pan, B., Hymowitz, S. G., et al. (2003) BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site, Biochemistry, 42, 5977–5983.
Hatada, E. N., Do, R. K., Orlofsky, A., et al. (2003) NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells, J. Immunol., 171, 761–768.
Roth, W., Wagenknecht, B., Klumpp, A., et al. (2001) APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis, Cell. Death Differ., 8, 403–410.
Nardelli, B., Belvedere, O., Roschke, V., et al. (2001) Synthesis and release of B- lymphocyte stimulator from myeloid cells, Blood, 97, 198–204.
Scapini, P., Nardelli, B., Nadali, G., et al. (2003) G-CSF-stimulated neutrophils are a prominent source of functional BLyS, J. Exp. Med., 197, 297–302.
Gorelik, L., Gilbride, K., Dobles, M., Kalled, S. L., Zandman, D., and Scott, M. L. (2003) Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells, J. Exp. Med., 198, 937–945.
Craxton, A., Magaletti, D., Ryan, E. J., and Clark, E. A. (2003) Macrophage- and dendritic cell-dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF, Blood, 101, 4464–4471.
Amanna, I. J., Dingwall, J. P., and Hayes, C. E. (2003) Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice, J. Immunol., 170(9), 4593–4600.
Schneider, P., Mackay, F., Steiner, V., et al. (1999) BAFF a novel ligand of the tumor necrosis factor family, stimulates B cell growth, J. Exp. Med., 189(11), 1747–1756.
Do, R. K., Hatada, E., Lee, H., Tourigny, M. R., Hilbert, D., and Chen-Kiang, S. (2000) Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response, J. Exp. Med., 192(7), 953–964.
Chiu, A., Xu, W., He, B., et al. (2007) Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL, Blood, 109(2), 729–739.
Fu, L., Lin-Lee, Y.-C., Pham, L. V., Tamayo, A., Yoshimura, L., and Ford, R. J. (2006) Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas, Blood, 107, 4540–4548.
Novak, A. J., Grote, D. M., Stenson, M., et al. (2004) Expression of BLyS and its receptors in B-cell non Hodgkin lymphoma: correlation with disease activity and patient outcome, Blood, 104(8), 2247–2253.
Moreaux, J., Legouffe, E., Jourdan, E., et al. (2004) BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone, Blood, 103(8), 3148–3157.
Ng, L. G., Sutherland, A. P., Newton, R., et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells, J. Immunol., 173(2), 807–817.
Groom, J., Kalled, S. L., Cutler, A. H., et al. (2002) Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren’s syndrome, J. Clin. Invest., 109(1), 59–68.
Zhang, J., Roschke, V., Baker, K. P., et al. (2001) Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus, J. Immunol., 166(1), 6–10.
Zhang, M., Ko, K. H., Lam, Q. L., et al. (2005) Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis, Int. Immunol., 17(8), 1081–1092.
Lesley, R., Xu, Y., Kalled, S. L., et al. (2004) Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF, Immunity, 20(4), 441–453.
Thien, M., Phan, T. G., Gardam, S., et al. (2004) Excess BAFF rescues self- reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches, Immunity, 20(6), 785–798.
Liu, W., Szalai, A., Zhao, L., et al. (2004), Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI, Arthritis Rheum., 50(6), 1884–1896.
Riccobene, T. A., Miceli, R. C., Lincoln, C., et al. (2003) Rapid and specific targeting of 125I-labeled B lymphocyte stimulator to lymphoid tissues and B cell tumors in mice, J. Nucl. Med., 44(3), 422–433.
Baker, K. P., Edwards, B. M., Main,S. H., et al. (2003) Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator, Arthritis Rheum., 48(11), 3253–3265.
Hernando, E., Charytonowitz, E., Dudas, M. E., et al. (2007) The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas, Nat. Med., 13, 748–753.
Berns, A., van der Lugt, N., Alkema, M., et al. (1994) Mouse model systems to study multistep tumorigenesis, Cold Spring Harb. Symp. Quant. Biol., 59, 435–447.
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Georgiev, V.S. (2009). The Role of B Cells. In: Georgiev, V.S. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-297-1_43
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