Protecting mucosal tissues from infection and inflammation is one of the most important challenges to immunology research today (1,2). Vaccines against pathogens that enter or target the mucosa include those for poliomyelitis, influenza, rotavirus, and genital papillomavirus, demonstrating the enormous benefits of protecting those complex tissues and using their potential as effective barriers against the entry of pathogenic microbes into the host. Among the mucosally spread diseases in urgent need of protective vaccines are HIV-AIDS and a potential pandemic influenza; however, many scientific hurdles still must be overcome in the development of such vaccines (3).
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Georgiev, V.S. (2009). Mucosal Immune System. In: Georgiev, V.S. (eds) National Institute of Allergy and Infectious Diseases, NIH. Infectious Disease. Humana Press. https://doi.org/10.1007/978-1-60327-297-1_42
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