Abstract
Bacteriophages are abundant biological entities and they play an enormous role in the adaptive evolution of bacteria. Vibrio cholerae O1 and O139 strains produce several types of spheroidal phages and filamentous phages, which are known to have genes encoding several virulence factors. Filamentous phages of V. cholerae O1 and O139 were classified into two types: fs1 and fs2. The fs1 has several subtypes and presumably play a great role in several epidemics. The receptor for filamentous phages fs1 and fs2 was shown to be the type IV fimbriae. Production of fimbriae was repressed even in the fimbriate strains due to infection with filamentous phages and this was confirmed using animal models. This chapter also describes background information regarding the development of effective cholera vaccine using phase variation in V. cholerae.
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Ehara, M., Albert, M.J. (2011). Filamentous Phages of Vibrio cholerae O1 and O139. In: Ramamurthy, T., Bhattacharya, S. (eds) Epidemiological and Molecular Aspects on Cholera. Infectious Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-60327-265-0_12
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DOI: https://doi.org/10.1007/978-1-60327-265-0_12
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