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Role of DNA Methylation and Epigenetics in Stem Cells

  • Chapter
Regulatory Networks in Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

In recent years, great strides have been made in our understanding of the biology of human embryonic stem cells and their ability to differentiate into multiple lineages. Although it has always been obvious that the differentiation of stem cells does not come about due to changes to the primary sequence of the genome, only now are we beginning to understand the mechanisms involved in this process. Chromatin modification has been shown to control the expression of key genes involved in the progression of stem cells into their differentiated progeny. In this chapter, some of the key regulatory mechanisms involved in epigenetic modification of the genome are discussed.

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  1. Invitrogen Corporation, 5781 Van Allen Way, Carlsbad, CA 92008

    Bhaskar Thyagarajan & Mahendra Rao

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  1. Bhaskar Thyagarajan
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  2. Mahendra Rao
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Correspondence to Bhaskar Thyagarajan .

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Editors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Vinagolu K. Rajasekhar MSc, MPhil, PhD

  2. Invitrogen Corporation, Frederick, MD, USA

    Mohan C. Vemuri Ph.D.

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Thyagarajan, B., Rao, M. (2009). Role of DNA Methylation and Epigenetics in Stem Cells. In: Rajasekhar, V.K., Vemuri, M.C. (eds) Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-227-8_22

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