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Aortic Aneurysms pp 1–26Cite as

Genetics of Abdominal Aortic Aneurysms

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Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Abdominal aortic aneurysm (AAA) is a multifactorial disease with a significant genetic component. Epidemiological studies have identified family history of AAA as a risk factor for both aneurysm development and rupture, making it an important consideration for targeted ultrasound screening of elderly patients and their family members. Ongoing research into the genetics of AAA is focused on identifying risk factor genes for both familial and sporadic aneurysms through the use of linkage analyses and genetic association studies, although no causative mutations have yet been identified. Additionally, micro-array expression profiling and animal models of aneurysms are being used to identify genes and pathways for the design of novel therapeutics. These approaches promise to deliver a better understanding of aneurysms at the molecular level leading to improved screening and treatment.

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Acknowledgments

The authors thank Dr. Gerard Tromp for preparing Fig. 1. The original work carried out in the Kuivaniemi laboratory was funded in part by the National Heart, Lung, and Blood Institute of the NIH (HL045996 and HL06410 to H.K.). J.H.L. is a recipient of a Predoctoral Fellowship from the National Institute on Aging, NIH (AG030900), and G.M.L. is a recipient of a Predoctoral Fellowship from the American Heart Association (0510063Z and 0710099Z).

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  1. Center for Molecular Medicine and Genetics, Department of Surgery, Wayne State University School of Medicine, Detroit, MI, USA

    John H. Lillvis, Guy M. Lenk & Helena Kuivaniemi

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  1. John H. Lillvis
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  1. Department of Surgery Sec. Vascular Surgery, University of Michigan Health System, 1500 E. Medical Center Dr., TC2210N, Ann Arbor, MI, 48109-0329, USA

    Gilbert R. Upchurch Jr.  & Enrique Criado  & 

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Lillvis, J.H., Lenk, G.M., Kuivaniemi, H. (2009). Genetics of Abdominal Aortic Aneurysms. In: Upchurch, G.R., Criado, E. (eds) Aortic Aneurysms. Contemporary Cardiology. Humana Press. https://doi.org/10.1007/978-1-60327-204-9_1

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