Demyelination is a significant component of contusive spinal cord injury as well as in multiple sclerosis. As such, remyelination, either by endogenous or grafted exogenous myelinating cells is a viable therapeutic target to restore function. To assess specific approaches to facilitate functional remyelination in vivo, appropriate injury models are needed. This chapter will discuss the strengths and weaknesses of a number of demyelinating lesions of the spinal cord and provide guidelines for choosing which model best suits which experimental condition. Step by step procedures for both creating and assessing the lesion will be provided.
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© 2009 Humana Press, a part of Springer Science + Business Media, LLC
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Jernigan, S.C., Zhang, Y.P., Shields, C.B., Whittemore, S.R. (2009). Rodent Spinal Cord Demyelination Models. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_40
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DOI: https://doi.org/10.1007/978-1-60327-185-1_40
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