An experimental laceration spinal cord injury (L-SCI) is an animal model designed to study mechanisms of axonal regeneration following SCI. Current techniques for creating L-SCI are performed freehand using visual estimation that cause significant errors in both the lesion depth and shape. In this chapter, we describe an unique method to create precise L-SCI in rodents using the Louisville Injury System Apparatus. We will explain the step-bystep procedure and describe the conditions that affect the outcomes following laceration injury.
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Zhang, Y.P., Shields, L.B., Shields, C.B. (2009). Experimental Laceration Spinal Cord Injury Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_39
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DOI: https://doi.org/10.1007/978-1-60327-185-1_39
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