The monofilament puncture model for the induction of a subarach-noid hemorrhage in the rat is a difficult procedure to master. It is, however, important to do so, not only for subarachnoid hemorrhage research but also for stroke models, as the procedure is very similar. The monofilament model is by far the best model for investigating subarachnoid hemorrhage. This model, although technically more difficult compared with other techniques, has become more popular of late as the injury created is more authentic. The following description will explain step by step how to master this procedure with ease.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Springer Nature is developing a new tool to find and evaluate Protocols. Learn more
References
Cahill, J., Calvert, J. W., Solaroglu, I., & Zhang, J. H. (2006). Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage. Stroke 37, 1868–1874.
Yamaguchi, M., Zhou, C., Nanda, A., & Zhang, J. H. (2004). Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Stroke 35, 1750–1755.
Zhou, C., Yamaguchi, M., Kusaka, G., Schonholz, C., Nanda, A., & Zhang, J. H. (2004). Caspase inhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 24, 419–431.
Zubkov, A. Y. , Aoki, K., Parent, A. D., & Zhang, J. H. (2002). Preliminary study of the effects of caspase inhibitors on vasospasm in dog penetrating arteries. Life Sci. 70, 3007–3018.
Prunell, G. F., Mathiesen, T., Diemer, N. H., & Svendgaard, N. A. (2003). Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery 52, 165–175.
Gules, I., Satoh, M., Clower, B. R., Nanda, A., & Zhang, J. H. (2002). Comparison of three rat models of cerebral vasospasm. Am. J. Physiol Heart Circ. Physiol. 283, H2551–H2559.
Bederson, J. B., Germano, I. M., & Guarino, L. (1995). Cortical blood flow and cerebral perfusion pressure in a new noncraniotomy model of subarachnoid hemorrhage in the rat. Stroke 26, 1086–1091.
Garcia, J. H., Wagner, S., Liu, K. F., & Hu, X. J. (1995). Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 26, 627–634.
Chang, K. S., Wang, K. Y., Yao, Y. W., Huang, J. L., Lee, W. L., Ho, H. Y., Hsueh, C. W., Huang, D. S., Chen, Y. T., & Ting, C. T. (2000). Catheter-induced coronary spasm—a view of mechanical factors and experience with selective left coronary arteriography. Zhonghua Yi. Xue. Za Zhi. (Taipei) 63, 107–112.
Kusaka, G., Ishikawa, M., Nanda, A., Granger, D. N., & Zhang, J. H. (2004). Signaling pathways for early brain injury after subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 24, 916–925.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Humana Press, a part of Springer Science + Business Media, LLC
About this protocol
Cite this protocol
Cahill, J., Zhang, J.H. (2009). Monofilament Perforation Subarachnoid Hemorrhage Rat Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_21
Download citation
DOI: https://doi.org/10.1007/978-1-60327-185-1_21
Publisher Name: Humana Press
Print ISBN: 978-1-60327-184-4
Online ISBN: 978-1-60327-185-1
eBook Packages: Springer Protocols