This chapter outlines the important points that must be considered in developing an animal protocol using a model of acute neurological injury. It highlights the issues that should be considered in designing such a study as well as the issues that must be addressed when writing a protocol for submission to the Institutional Animal Care and Use Committee (IACUC). The key issues for regulatory compliance are addressed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
CFR (Code of Federal Regulations). 1985. Title 9: Animals and Animal Products, Chapter 1, Subchapter A: Animal Welfare. Washington, DC: Office of Federal Register
PHS (Public Health Service). 1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Washington, DC: U.S. Department of Health and Human Services, 28 pp. [PL 99–158, Health Research Extension Act, 1985]
IRAC (Interagency Research Animal Committee). 1985 US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Washington, DC: Office of Science and Technology Policy
NRC (National Research Council). 2003. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research. Washington, DC: National Academies Press
NRC (National Research Council). 1996. The Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academies Press
NIH (National Institutes of Health). 2002. Methods and Welfare Considerations in Behavioral Research with Animals: Report of a National Institutes of Health Workshop. Morrison, A.R., Evans, H.L., Ator, N.A., Nakamura, R.K. (eds). NIH Publication No. 02–5083. Washington, DC: US Government Printing Office
Stokes, W.S. Reducing unrelieved pain and distress in laboratory animals using humane endpoints. ILAR J 2000; 41(2):59–61
ARENA-OLAW (Applied Research Ethics National Association – Office of Laboratory Animal Welfare). 2002. Institutional Animal Care and Use Committee Guidebook (2nd ed). Washington, DC: US Government Printing Press
Morton, D.B. A systematic approach for establishing humane endpoints. ILAR J 2000; 41(2):80–86
AVMA (American Veterinary Medical Association). 2000 Report of the AVMA panel on euthanasia. J Am Vet Med Assoc. 2001; 218(5):669–696
NRC (National Research Council). 1997. Occupational Health and Safety in the Care and Use of Research Animals. Washington, DC: National Academies Press
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Humana Press, a part of Springer Science + Business Media, LLC
About this protocol
Cite this protocol
Schantz, L.D. (2009). Animal Protocol. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_1
Download citation
DOI: https://doi.org/10.1007/978-1-60327-185-1_1
Publisher Name: Humana Press
Print ISBN: 978-1-60327-184-4
Online ISBN: 978-1-60327-185-1
eBook Packages: Springer Protocols