Abstract
The majority of acute coronary syndromes are the result of coronary plaque rupture. Recent studies have revealed the presence of neovascularization in and around the plaque to be a common feature of presumed rupture-prone (vulnerable) plaques. Intravascular ultrasound combined with contrast enhancement agents has been shown to be useful for the detection and quantification of vasa vasorum (VV) and angiogenesis within the vessel wall. In this chapter, the two state-of-the-art techniques for VV imaging are reviewed.
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M. Naghavi, P. Libby, E. Falk, S. W. Casscells, S. Litovsky, J. Rumberger, J. J. Badimon, C. Stefanadis, P. Moreno, G. Pasterkamp, Z. Fayad, P. H. Stone, S. Waxman, P. Raggi, M. Madjid, A. Zarrabi, A. Burke, C. Yuan, P. J. Fitzgerald, D. S. Siscovick, C. L. de Korte, M. Aikawa, K. E. Airaksinen, G. Assmann, C. R. Becker, J. H. Chesebro, A. Farb, Z. S. Galis, C. Jackson, I. K. Jang, W. Koenig, R. A. Lodder, K. March, J. Demirovic, M. Navab, S. G. Priori, M. D. Rekhter, R. Bahr, S. M. Grundy, R. Mehran, A. Colombo, E. Boerwinkle, C. Ballantyne, W. Insull, Jr., R. S. Schwartz, R. Vogel, P. W. Serruys, G. K. Hansson, D. P. Faxon, S. Kaul, H. Drexler, P. Greenland, J. E. Muller, R. Virmani, P. M. Ridker, D. P. Zipes, P. K. Shah, and J. T. Willerson, “From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I,” Circulation, vol. 108, pp. 1664–1672, 2003.
A. P. Burke, A. Farb, G. T. Malcom, Y. Liang, J. Smialek, and R. Virmani, “Coronary risk factors and plaque morphology in men with coronary disease who died suddenly,” N Engl J Med, vol. 336, pp. 1276–1282, 1997.
P. Constantinides, “Cause of thrombosis in human atherosclerotic arteries,” Am J Cardiol, vol. 66, pp. 37G–40G, 1990.
F. D. Kolodgie, A. P. Burke, A. Farb, H. K. Gold, J. Yuan, J. Narula, A. V. Finn, and R. Virmani, “The thin-cap fibroatheroma: A type of vulnerable plaque: The major precursor lesion to acute coronary syndromes,” Curr Opin Cardiol, vol. 16, pp. 285–292, 2001.
R. Virmani, F. D. Kolodgie, A. P. Burke, A. V. Finn, H. K. Gold, T. N. Tulenko, S. P. Wrenn, and J. Narula, “Atherosclerotic plaque progression and vulnerability to rupture: Angiogenesis as a source of intraplaque hemorrhage,” Arterioscler Thromb Vasc Biol, vol. 25, pp. 2054–2061, 2005.
R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, “Lessons from sudden coronary death a comprehensive morphological classification scheme for atherosclerotic lesions,” Arterioscler Thromb Vasc Biol, vol. 20, pp. 1262–1275, 2000.
M. Vavuranakis, T. G. Papaioannou, I. A. Kakadiaris, S. M. O’Malley, M. Naghavi, K. Filis, E. A. Sanidas, A. Papalois, I. Stamatopoulos, and C. Stefanadis, “Detection of perivascular blood flow in vivo by contrast-enhanced intracoronary ultrasonography and image analysis: An animal study,” Clin Exp Pharmacol Physiol, vol. 34, pp. 1319–1323, 2007.
D. D. Heistad and M. L. Marcus, “Role of vasa vasorum in nourishment of the aorta,” Blood Vessels, vol. 16, pp. 225–238, 1979.
C. Stefanadis, C. Vlachopoulos, P. Karayannacos, H. Boudoulas, C. Stratos, T. Filippides, M. Agapitos, and P. Toutouzas, “Effect of vasa vasorum flow on structure and function of the aorta in experimental animals,” Circulation, vol. 91, pp. 2669–2678, 1995.
H. M. Kwon, G. Sangiorgi, E. L. Ritman, C. McKenna, D. R. Holmes Jr, R. S. Schwartz, and A. Lerman, “Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia,” J Clin Invest, vol. 101, p. 1551–6, 1998.
P. R. Moreno, K. R. Purushothaman, V. Fuster, and W. N. O’Connor, “Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: Implications for plaque vulnerability,” Circulation, vol. 105, pp. 2504–2511, 2002.
K. S. Moulton, K. Vakili, D. Zurakowski, M. Soliman, C. Butterfield, E. Sylvin, K. M. Lo, S. Gillies, K. Javaherian, and J. Folkman, “Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis,” Proc Natl Acad Sci USA, 2003, vol. 100, pp. 4736–4741.
M. Fleiner, M. Kummer, M. Mirlacher, G. Sauter, G. Cathomas, R. Krapf, and B. C. Biedermann, “Arterial neovascularization and inflammation in vulnerable patients: Early and late signs of symptomatic atherosclerosis,” Circulation, vol. 110, pp. 2843–2850, 2004.
P. R. Moreno, K. R. Purushothaman, V. Fuster, D. Echeverri, H. Truszczynska, S. K. Sharma, J. J. Badimon, and W. N. O’Connor, “Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: Implications for plaque vulnerability,” Circulation, vol. 110, pp. 2032–2038, 2004.
F. D. Kolodgie, H. K. Gold, A. P. Burke, D. R. Fowler, H. S. Kruth, D. K. Weber, A. Farb, L. J. Guerrero, M. Hayase, R. Kutys, J. Narula, A. V. Finn, and R. Virmani, “Intraplaque hemorrhage and progression of coronary atheroma,” N Engl J Med, vol. 349, pp. 2316–2325, 2003.
M. R. Hayden and S. C. Tyagi, “Vasa vasorum in plaque angiogenesis, metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: A malignant transformation,” Cardiovasc Diabetol, vol. 3, 1, 2004.
N. de Jong, A. Bouakaz, and F. J. T. Cate, “Contrast harmonic imaging,” Ultrasonics, vol. 40, pp. 567–573, 2002.
S. M. O’Malley, M. Vavuranakis, M. Naghavi, and I. A. Kakadiaris, “Intravascular ultrasound-based imaging of vasa vasorum for the detection of vulnerable atherosclerotic plaque,” Int Conf Med Image Comput Comput Assist Interv, 2005 vol. 8, pp. 343–351.
M. Vavuranakis, I. A. Kakadiaris, S. M. O’Malley, C. Stefanadis, S. Vaina, M. Drakopoulou, I. Mitropoulos, S. Carlier, and M. Naghavi, “Detection of luminal-intimal border and coronary wall enhancement in intravascular ultrasound imaging after injection of microbubbles and simultaneous sonication with transthoracic echocardiography,” Circulation, vol. 112, pp. e1–e2, 2005.
S. Carlier, I. A. Kakadiaris, N. Dib, M. Vavuranakis, C. Stefanadis, S. M. O’Malley, C. J. Hartley, R. W. Metcalfe, R. Mehran, E. Falk, K. Gul, and M. Naghavi, “Vasa vasorum imaging: A new window to the clinical detection of vulnerable atherosclerotic plaques,” Curr Atheroscler Rep, vol. 7, pp. 164–169, 2005.
D. E. Goertz, M. E. Frijlink, N. de Jong, and A. F. van der Steen, “Nonlinear intravascular ultrasound contrast imaging,” Ultrasound Med Biol, vol. 32, pp. 491–502, 2006.
D. E. Goertz, M. E. Frijlink, D. Tempel, L. C. A. van Damme, R. Krams, J. A. Schaar, F. J. ten Cate, P. W. Serruys, N. de Jong, and A. F. W. van der Steen, “Contrast harmonic intravascular ultrasound: A feasibility study for vasa vasorum imaging,” Invest Radiol, vol. 41, pp. 631–638, 2006.
D. E. Goertz, M. E. Frijlink, D. Tempel, V. Bhagwandas, A. Gisolf, R. Krams, N. de Jong, and A. F. van der Steen, “Subharmonic contrast intravascular ultrasound for vasa vasorum imaging,” Ultrasound Med Biol, vol. 33, pp. 1859–1872, 2007.
M. E. Frijlink, D. E. Goertz, L. C. A. van Damme, R. Krams, and A. F. van der Steen, “Intravascular ultrasound tissue harmonic imaging in vivo,” Ultrasonics Symposium, 2004 IEEE, vol. 2, pp. 1118–1121, 2004.
M. E. Frijlink, D. E. Goertz, H. J. Vos, E. Tesselaar, G. Blacquicre, A. Gisolf, R. Krams, and A. F. W. van der Steen, “Harmonic intravascular ultrasound imaging with a dual-frequency catheter,” Ultrasound Med Biol, vol. 32, pp. 1649–1654, 2006.
M. Vavuranakis, I. A. Kakadiaris, S. M. O’Malley, T. G. Papaioannou, E. A. Sanidas, M. Naghavi, S. Carlier, D. Tousoulis, and C. Stefanadis, “A new method for assessment of plaque vulnerability based on vasa vasorum imaging, by using contrast-enhanced intravascular ultrasound and differential image analysis,” Int J Cardiol, vol. 130, pp. 23–29, 2008.
Acknowledgments
We would like to thank S. Carlier, J. Granada, N. Dib, C. Stefanadis, T. Papaioannou, S. Vaina, M. Drakopoulou, and I. Mitropoulos for their contributions and assistance on the UIVUS project. Vasa Vasorum detection and quantification using differential imaging was supported in part by NSF Grant IIS-0431144 and an NSF Graduate Research Fellowship (SMO). Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the NSF.
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Kakadiaris, I.A. et al. (2011). Vasa Vasorum Imaging. In: Naghavi, M. (eds) Asymptomatic Atherosclerosis. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-179-0_38
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DOI: https://doi.org/10.1007/978-1-60327-179-0_38
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