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Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms

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Asymptomatic Atherosclerosis

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Endothelial cell (EC) activation mediates inflammation and involves several effectors such as E-selectin, P-selectin, ICAM-1, and VCAM-1. These EC activation markers are detected to be significantly increased in clinical coronary artery disease (CAD), and mildly increased in subclinical CAD compared with non-disease reference groups. Because inflammation is implicated in all stages of CAD and thought to underlie plaque destabilization and rupture, monitoring the increase in EC activation markers could be a surrogate endpoint in the monitoring of subclinical coronary artery disease (subCAD) progression, and/or response to prevention/intervention strategies. While CAD progression is complex, and requires the contemporaneous analysis of multi-pathway markers, monitoring EC activation markers could provide insight into subCAD progression, especially when levels approach those detected in acute coronary syndromes (ACS). Clearly, mechanism-based deductions provide compelling evidence that EC activation markers should be integrated into the management of subCAD; however, much study remains to be done.

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Author information

Authors and Affiliations

  1. Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, Boston, MA, USA

    Victoria L. M. Herrera

  2. Department of Medicine, Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, USA

    Joseph A. Vita

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  1. Victoria L. M. Herrera
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  2. Joseph A. Vita
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  1. Endothelix, Inc., El Rio 8275, Houston, 77054, USA

    Morteza Naghavi

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Herrera, V.L.M., Vita, J.A. (2011). Endothelial Activation Markers in Sub-clinical Atherosclerosis: Insights from Mechanism-Based Paradigms. In: Naghavi, M. (eds) Asymptomatic Atherosclerosis. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-179-0_13

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  • DOI: https://doi.org/10.1007/978-1-60327-179-0_13

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  • Publisher Name: Humana Press, Totowa, NJ

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  • Online ISBN: 978-1-60327-179-0

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