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References
Gerich J, Davis J, Lorenzi M, et al. Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol 1979; 236(4):E380–5.
Cryer PE. Glucose counterregulation: prevention and correction of hypoglycemia in humans. Am J Physiol 1993; 264(2 Pt 1):E149–55.
Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988; 37(7):901–7.
Mitrakou A, Fanelli C, Veneman T, et al. Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 1993; 329(12):834–9.
Cryer PE. Diverse causes of hypoglycemia-associated autonomic failure in diabetes. N Engl J Med 2004; 350(22):2272–9.
Cryer PE, A. Kalsbeek. Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation. In: Progress in Brain Research: Elsevier; 2006:361–5.
Merimee TJ, Tyson JE. Stabilization of plasma glucose during fasting; Normal variations in two separate studies. N Engl J Med 1974; 291(24):1275–8.
Whipple AO. The surgical therapy of hyperinsulinism. J Int Chir 1938; 3:237–76.
Hepburn DA, Deary IJ, Frier BM, Patrick AW, Quinn JD, Fisher BM. Symptoms of acute insulin-induced hypoglycemia in humans with and without IDDM. Factor-analysis approach. Diabetes Care 1991; 14(11):949–57.
Towler DA, Havlin CE, Craft S, Cryer P. Mechanism of awareness of hypoglycemia. Perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 1993; 42(12):1791–8.
Fischer KF, Lees JA, Newman JH. Hypoglycemia in hospitalized patients. Causes and outcomes. N Engl J Med 1986; 315(20):1245–50.
Holstein A, Plaschke A, Egberts EH. Incidence and costs of severe hypoglycemia. Diabetes Care 2002; 25(11):2109–10.
Johnson ES, Koepsell TD, Reiber G, Stergachis A, Platt R. Increasing incidence of serious hypoglycemia in insulin users. J Clin Epidemiol 2002; 55(3):253–9.
Hart SP, Frier BM. Causes, management and morbidity of acute hypoglycaemia in adults requiring hospital admission. Qjm 1998; 91(7):505–10.
Vriesendorp TM, van Santen S, DeVries JH, et al. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med 2006; 34(1):96–101.
Su CC. Etiologies of acute hypoglycemia in a Taiwanese hospital emergency department. J Emerg Med 2006; 30(3):259–61.
Malouf R, Brust JC. Hypoglycemia: causes, neurological manifestations, and outcome. Ann Neurol 1985; 17(5):421–30.
Hypoglycemia in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group. Diabetes 1997; 46(2):271–86.
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352(9131):837–53.
Leese GP, Wang J, Broomhall J, et al. Frequency of severe hypoglycemia requiring emergency treatment in type 1 and type 2 diabetes: a population-based study of health service resource use. Diabetes Care 2003; 26(4):1176–80.
Shorr RI, Ray WA, Daugherty JR, Griffin MR. Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas. Arch Intern Med 1997; 157(15):1681–6.
Service FJ. Hypoglycemic disorders. N Engl J Med 1995; 332(17):1144–52.
Shilo S, Berezovsky S, Friedlander Y, Sonnenblick M. Hypoglycemia in hospitalized nondiabetic older patients. J Am Geriatr Soc 1998; 46(8):978–82.
Charles MA, Hofeldt F, Shackelford A, et al. Comparison of oral glucose tolerance tests and mixed meals in patients with apparent idiopathic postabsorptive hypoglycemia: absence of hypoglycemia after meals. Diabetes 1981; 30(6):465–70.
Palardy J, Havrankova J, Lepage R, et al. Blood glucose measurements during symptomatic episodes in patients with suspected postprandial hypoglycemia. N Engl J Med 1989; 321(21):1421–5.
Fariss BL. Prevalence of post-glucose-load glycosuria and hypoglycemia in a group of healthy young men. Diabetes 1974; 23(3):189–91.
Hofeldt FD. Reactive hypoglycemia. Metabolism 1975; 24(10):1193–208.
Lev-Ran A, Anderson RW. The diagnosis of postprandial hypoglycemia. Diabetes 1981; 30(12):996–9.
Hofeldt FD. Reactive hypoglycemia. Endocrinol Metab Clin North Am 1989; 18(1):185–201.
Service GJ, Thompson GB, Service FJ, Andrews JC, Collazo-Clavell ML, Lloyd RV. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric-bypass surgery. N Engl J Med 2005; 353(3):249–54.
Patti ME, McMahon G, Mun EC, et al. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 2005; 48(11):2236–40.
Meier JJ, Butler AE, Galasso R, Butler PC. Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery Is Not Accompanied by Islet Hyperplasia or Increased {beta}-Cell Turnover. Diabetes Care 2006; 29(7):1554–9.
Grunberger G, Weiner JL, Silverman R, Taylor S, Gorden P. Factitious hypoglycemia due to surreptitious administration of insulin. Diagnosis, treatment, and long-term follow-up. Ann Intern Med 1988; 108(2):252–7.
van Staa T, Abenhaim L, Monette J. Rates of hypoglycemia in users of sulfonylureas. J Clin Epidemiol 1997; 50(6):735–41.
Duncan GG, Jenson W, Eberly RJ. Factitious hypoglycemia due to chlorpropamide. Report of a case, with clinical similarity to an islet cell tumor of the pancreas. Jama 1961; 175:904–6.
Jordan RM, Kammer H, Riddle MR. Sulfonylurea-induced factitious hypoglycemia. A growing problem. Arch Intern Med 1977; 137(3):390–3.
Fernando R. Homicidal poisoning with glibenclamide. Med Sci Law 1999; 39(4):354–8.
Manning PJ, Espiner EA, Yoon K, Drury PL, Holdaway IM, Bowers A. An unusual cause of hyperinsulinaemic hypoglycaemia syndrome. Diabet Med 2003; 20(9):772–6.
Sketris I, Wheeler D, York S. Hypoglycemic coma induced by inadvertent administration of glyburide. Drug Intell Clin Pharm 1984; 18(2):142–3.
Scala-Barnett DM, Donoghue ER. Dispensing error causing fatal chlorpropamide intoxication in a nondiabetic. J Forensic Sci 1986; 31(1):293–5.
Field JB, Williams HE, Mortimore GE. Studies on the mechanism of ethanol-induced hypoglycemia. J Clin Invest 1963; 42:497–506.
Lumeng L, Davis EJ. Mechanism of ethanol suppression of gluconeogenesis. Inhibition of phosphoenolpyruvate synthesis from glutamate and alpha-ketaglutarate. J Biol Chem 1970; 245(12):3179–85.
Zaleski J, Bryla J. Ethanol-induced impairment of gluconeogenesis from lactate in rabbit hepatocytes: correlation with an increased reduction of mitochondrial NAD pool. Int J Biochem 1980; 11(3–4):237–42.
Madison LL, Lochner A, Wulff J. Ethanol-induced hypoglycemia. II. Mechanism of suppression of hepatic gluconeogenesis. Diabetes 1967; 16(4):252–8.
Arena FP, Dugowson C, Saudek CD. Salicylate-induced hypoglycemia and ketoacidosis in a nondiabetic adult. Arch Intern Med 1978; 138(7):1153–4.
Raschke R, Arnold-Capell PA, Richeson R, Curry SC. Refractory hypoglycemia secondary to topical salicylate intoxication. Arch Intern Med 1991; 151(3):591–3.
Hirsch IB, Boyle PJ, Craft S, Cryer PE. Higher glycemic thresholds for symptoms during beta-adrenergic blockade in IDDM. Diabetes 1991; 40(9):1177–86.
Poretsky L, Moses AC. Hypoglycemia associated with trimethoprim/sulfamethoxazole therapy. Diabetes Care 1984; 7(5):508–9.
Waskin H, Stehr-Green JK, Helmick CG, Sattler FR. Risk factors for hypoglycemia associated with pentamidine therapy for Pneumocystis pneumonia. Jama 1988; 260(3):345–7.
Taylor TE, Molyneux ME, Wirima JJ, Fletcher KA, Morris K. Blood glucose levels in Malawian children before and during the administration of intravenous quinine for severe falciparum malaria. N Engl J Med 1988; 319(16):1040–7.
Limburg PJ, Katz H, Grant CS, Service FJ. Quinine-induced hypoglycemia. Ann Intern Med 1993; 119(3):218–9.
Barbato M. Another problem with Kinidin. Med J Aust 1984; 141(10):685.
Goldberg IJ, Brown LK, Rayfield EJ. Disopyramide (Norpace)-induced hypoglycemia. Am J Med 1980; 69(3):463–6.
Graumlich JF, Habis S, Avelino RR, et al. Hypoglycemia in inpatients after gatifloxacin or levofloxacin therapy: nested case-control study. Pharmacotherapy 2005; 25(10):1296–302.
Park-Wyllie LY, Juurlink DN, Kopp A, et al. Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med 2006; 354(13):1352–61.
Chiolero R, Tappy L, Gillet M, et al. Effect of major hepatectomy on glucose and lactate metabolism. Ann Surg 1999; 229(4):505–13.
Luo JC, Hwang SJ, Wu JC, et al. Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. Cancer 1999; 86(5):799–804.
Felig P, Brown WV, Levine RA, Klatskin G. Glucose homeostasis in viral hepatitis. N Engl J Med 1970; 283(26):1436–40.
Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care 2001; 24(2):382–91.
Sovik O, Oseid S, Vidnes J. Ketotic hypoglycemia in a four-year-old boy with adrenal cortical insufficiency. Acta Paediatr Scand 1972; 61(4):465–9.
Artavia-Loria E, Chaussain JL, Bougneres PF, Job JC. Frequency of hypoglycemia in children with adrenal insufficiency. Acta Endocrinol Suppl (Copenh) 1986; 279:275–8.
Pia A, Piovesan A, Tassone F, et al. A rare case of adulthood-onset growth hormone deficiency presenting as sporadic, symptomatic hypoglycemia. J Endocrinol Invest 2004; 27(11):1060–4.
Nadler HL, Neumann LL, Gershberg H. Hypoglycemia, Growth Retardation, and Probable Isolated Growth Hormone Deficiency in a 1-Year-Old Child. J Pediatr 1963; 63:977–83.
LaFranchi S, Buist NR, Jhaveri B, Klevit H. Amino acids as substrates in children with growth hormone deficiency and hypoglycemia. Pediatrics 1981; 68(2):260–4.
Wolfsdorf JI, Sadeghi-Nejad A, Senior B. Hypoketonemia and age-related fasting hypoglycemia in growth hormone deficiency. Metabolism 1983; 32(5):457–62.
De Feo P, Perriello G, Torlone E, et al. Demonstration of a role for growth hormone in glucose counterregulation. Am J Physiol 1989; 256(6 Pt 1):E835–43.
De Feo P, Perriello G, Torlone E, et al. Contribution of cortisol to glucose counterregulation in humans. Am J Physiol 1989; 257(1 Pt 1):E35–42.
Khani S, Tayek JA. Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome. Clin Sci (Lond) 2001; 101(6):739–47.
Boyle PJ, Cryer PE. Growth hormone, cortisol, or both are involved in defense against, but are not critical to recovery from, hypoglycemia. Am J Physiol 1991; 260(3 Pt 1):E395–402.
Megyesi K, Kahn CR, Roth J, Gorden P. Hypoglycemia in association with extrapancreatic tumors: demonstration of elevated plasma NSILA-s by a new radioreceptor assay. J Clin Endocrinol Metab 1974; 38(5):931–4.
Gorden P, Hendricks CM, Kahn CR, Megyesi K, Roth J. Hypoglycemia associated with non-islet-cell tumor and insulin-like growth factors. N Engl J Med 1981; 305(24):1452–5.
Daughaday WH, Emanuele MA, Brooks MH, Barbato AL, Kapadia M, Rotwein P. Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N Engl J Med 1988; 319(22):1434–40.
Daughaday WH, Kapadia M. Significance of abnormal serum binding of insulin-like growth factor II in the development of hypoglycemia in patients with non-islet-cell tumors. Proc Natl Acad Sci U S A 1989; 86(17):6778–82.
Daughaday WH, Trivedi B. Measurement of derivatives of proinsulin-like growth factor-II in serum by a radioimmunoassay directed against the E-domain in normal subjects and patients with nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab 1992; 75(1):110–5.
Wu JC, Daughaday WH, Lee SD, et al. Radioimmunoassay of serum IGF-I and IGF-II in patients with chronic liver diseases and hepatocellular carcinoma with or without hypoglycemia. J Lab Clin Med 1988; 112(5):589–94.
Ishida S, Noda M, Kuzuya N, et al. Big insulin-like growth factor II-producing hepatocellular carcinoma associated with hypoglycemia. Intern Med 1995; 34(12):1201–6.
Todd JF, Stanley SA, Roufosse CA, et al. A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes. Lancet 2003; 361(9353):228–30.
Shetty MR, Boghossian HM, Duffell D, Freel R, Gonzales JC. Tumor-induced hypoglycemia: a result of ectopic insulin production. Cancer 1982; 49(9):1920–3.
Morgello S, Schwartz E, Horwith M, King ME, Gorden P, Alonso DR. Ectopic insulin production by a primary ovarian carcinoid. Cancer 1988; 61(4):800–5.
Seckl MJ, Mulholland PJ, Bishop AE, et al. Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med 1999; 341(10):733–6.
Service FJ, Dale AJ, Elveback LR, Jiang NS. Insulinoma: clinical and diagnostic features of 60 consecutive cases. Mayo Clin Proc 1976; 51(7):417–29.
Service FJ, McMahon MM, O'Brien PC, Ballard DJ. Functioning insulinoma – incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin Proc 1991; 66(7):711–9.
Hirshberg B, Livi A, Bartlett DL, et al. Forty-eight-hour fast: the diagnostic test for insulinoma. J Clin Endocrinol Metab 2000; 85(9):3222–6.
Service FJ, Natt N, Thompson GB, et al. Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. J Clin Endocrinol Metab 1999; 84(5):1582–9.
Thompson GB, Service FJ, Andrews JC, et al. Noninsulinoma pancreatogenous hypoglycemia syndrome: an update in 10 surgically treated patients. Surgery 2000; 128(6):937–44;discussion 44–5.
Kane C, Shepherd RM, Squires PE, et al. Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nat Med 1996; 2(12):1344–7.
Nestorowicz A, Wilson BA, Schoor KP, et al. Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews. Hum Mol Genet 1996; 5(11):1813–22.
Thomas P, Ye Y, Lightner E. Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Mol Genet 1996; 5(11):1809–12.
Nestorowicz A, Inagaki N, Gonoi T, et al. A nonsense mutation in the inward rectifier potassium channel gene, Kir6.2, is associated with familial hyperinsulinism. Diabetes 1997; 46(11):1743–8.
Glaser B, Kesavan P, Heyman M, et al. Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med 1998; 338(4):226–30.
Stanley CA, Lieu YK, Hsu BY, et al. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 1998; 338(19):1352–7.
Khokher MA, Avasthy N, Taylor AM, Fonseca VA, Dandona P. Insulin-receptor antibody and hypoglycaemia associated with Hodgkin's disease. Lancet 1987; 1(8534):693–4.
Moller DE, Ratner RE, Borenstein DG, Taylor SI. Autoantibodies to the insulin receptor as a cause of autoimmune hypoglycemia in systemic lupus erythematosus. Am J Med 1988; 84(2):334–8.
Arioglu E, Andewelt A, Diabo C, Bell M, Taylor SI, Gorden P. Clinical course of the syndrome of autoantibodies to the insulin receptor (type B insulin resistance): a 28-year perspective. Medicine (Baltimore) 2002; 81(2):87–100.
Taylor SI, Barbetti F, Accili D, Roth J, Gorden P. Syndromes of autoimmunity and hypoglycemia. Autoantibodies directed against insulin and its receptor. Endocrinol Metab Clin North Am 1989; 18(1):123–43.
Hirata Y, Tominaga M, Ito JI, Noguchi A. Spontaneous hypoglycemia with insulin autoimmunity in Graves' disease. Ann Intern Med 1974; 81(2):214–8.
Redmon B, Pyzdrowski KL, Elson MK, Kay NE, Dalmasso AP, Nuttall FQ. Hypoglycemia due to an insulin-binding monoclonal antibody in multiple myeloma. N Engl J Med 1992; 326(15):994–8.
Blackshear PJ, Rotner HE, Kriauciunas KA, Kahn CR. Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. Ann Intern Med 1983; 99(2):182–4.
Gorden P, Skarulis MC, Roach P, et al. Plasma proinsulin-like component in insulinoma: a 25-year experience. J Clin Endocrinol Metab 1995; 80(10):2884–7.
Gruppuso PA, Gorden P, Kahn CR, Cornblath M, Zeller WP, Schwartz R. Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. N Engl J Med 1984; 311(10):629–34.
Hirshberg B, Cochran C, Skarulis MC, et al. Malignant insulinoma: spectrum of unusual clinical features. Cancer 2005; 104(2):264–72.
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Guettier, JM., Gorden, P. (2008). Hypoglycemia: An Endocrine Emergency. In: Acute Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60327-177-6_7
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