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The Adrenal Response to Critical Illness

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Acute Endocrinology

Part of the book series: Contemporary Endocrinology ((COE))

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References

  1. Waterhouse R. Case of suprarenal apoplexy. Lancet 1911; 1: 577.

    Article  Google Scholar 

  2. Melby JC et al. Comparative studies on adrenal cortical function and cortisol metabolism in healthy adults and in patients with shock due to infection. J Clin Invest 1958; 37: 1791–1798.

    Article  CAS  PubMed  Google Scholar 

  3. Koo DJ et al. Adrenal insufficiency during the late stage of polymicrobial sepsis. Crit Care Med 2001; 29: 618–622.

    Article  CAS  PubMed  Google Scholar 

  4. Carlson DE et al. Cecal ligation and puncture in rats interrupts the circadian rhythms of corticosterone and adrenocortical responsiveness to adrenocorticotrophic hormone. Crit Care Med 2006; 34: 1178–1184.

    Article  CAS  PubMed  Google Scholar 

  5. Burkitt JM et al. Relative adrenal insufficiency in dogs with sepsis. J Vet Inter Med 2007; 21: 226–231.

    Article  Google Scholar 

  6. Wang P et al. Mechanism of adrenal insufficiency following trauma and severe hemorrhage: role of hepatic 11beta-hydroxysteroid dehydrogenase. Arch Surg 1999; 134: 394–401.

    Article  CAS  PubMed  Google Scholar 

  7. Annane D et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000; 283: 1038–1045.

    Article  CAS  PubMed  Google Scholar 

  8. Dimopoulo I et al. Hypothalamic-pituitary-adrenal axis dysfunction in critically ill patients with traumatic brain injury: incidence, pathophysiology, and relationship to vasopressor dependence and peripheral interleukin-6 levels. Crit Care Med 2004; 32: 404–408.

    Article  Google Scholar 

  9. Lipiner-Friedman D et al. Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med 2006; 35: 1012–1018.

    Article  Google Scholar 

  10. Marik PE et al. The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med 2005; 33: 1254–1259.

    Article  PubMed  Google Scholar 

  11. Tsai MH et al. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 2006; 43: 673–681.

    Article  PubMed  Google Scholar 

  12. Annane D et al. Diagnosis of adrenal insufficiency in severe sepsis and septic shock. Am J Respir Crit Care Med 2006; 174: 1319–1326.

    Article  PubMed  Google Scholar 

  13. Borovikova LV et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458–462.

    Article  CAS  PubMed  Google Scholar 

  14. Banks WA et al. Leptin enters the brain by a saturable system independent of insulin. Peptides 1996; 17: 305–311.

    Article  CAS  PubMed  Google Scholar 

  15. Koenig JI Presence of cytokines in the hypothalamic-pituitary axis. Prog Neuroendocrinoimmunol 1991; 4: 143–147.

    Google Scholar 

  16. Spangelo BL et al. Production of interleukin- 6 by anterior pituitary cells in vitro. Endocrinology 1990; 126: 582–586.

    Article  CAS  PubMed  Google Scholar 

  17. Sharshar T et al. The neuropathology of septic shock. Brain Pathol. 2004; 14: 21–33.

    Article  PubMed  Google Scholar 

  18. McCann SM et al. The mechanism of action of cytokines to control the release of hypothalamic and pituitary hormones in infection. Ann NY Acad Sci 2004; 917: 4–18.

    Article  Google Scholar 

  19. Sharshar T et al. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003; 362: 1799–1805.

    Article  CAS  PubMed  Google Scholar 

  20. Wong ML et al. Interleukin (IL) 1b, IL-1 receptor antagonist, IL-10, IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications. PNAS USA 1997; 93: 227–232.

    Article  Google Scholar 

  21. Rettori V et al. An interleukin-1α-like neuronal system in the preoptic-hypothalamic region and its induction by bacterial lipopolysaccharide in concentrations which alter pituitary hormone release. Neuroimmunomodulation 1994; 1: 251–258.

    Article  CAS  PubMed  Google Scholar 

  22. Gloddek J et al. The intrapituitary stimulatory effect of lipopolysaccharide on ACTH secretion is mediated by paracrine-acting IL-6. Exp Clin Endocrinol Diabetes 2001; 109: 410–415.

    Article  CAS  PubMed  Google Scholar 

  23. Annane et al. Norepinephrine plus dobutamine versus epinephrine alone for the management of septic shock. Lancet 2007; 370: 676–84.

    Google Scholar 

  24. Prigent H et al. Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care 2004; 8: 243–252.

    Article  PubMed  Google Scholar 

  25. Sharshar T et al. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 2003; 362: 1799.

    Article  CAS  PubMed  Google Scholar 

  26. Maxime V et al. Metabolism modulators in sepsis: The abnormal pituitary response. Crit Care Med 2007; 35: 5596–601.

    Google Scholar 

  27. Jaattela M et al. Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 1991; 128: 623–629.

    Article  CAS  PubMed  Google Scholar 

  28. Swain MG et al. Tumor necrosis factor-alpha stimulates adrenal glucocorticoid secretion in cholestatic rats. Am J Physiol 1996; 270: G987–G991.

    CAS  PubMed  Google Scholar 

  29. Salas MA et al. Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells. Clin Exp Immunol. 1990; 79: 470–473.

    Article  CAS  PubMed  Google Scholar 

  30. Smith EM et al. IL-10 as a mediator in the HPA axis and brain. J Neuroimmunol 1999; 100: 140–148.

    Article  CAS  PubMed  Google Scholar 

  31. Wheatland R. Molecular mimicry of ACTH in SARS – implications for corticosteroids treatment and prophylaxis. Med Hypotheses 2004; 63: 855–862.

    Article  CAS  PubMed  Google Scholar 

  32. Barnes PJ How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol. 2006; 148: 245–254.

    Article  CAS  PubMed  Google Scholar 

  33. Beishuizen A et al. Patterns of corticosteroid-binding globulin and the free cortisol index during septic shock and multitrauma. Intensive Care Med. 2001; 27: 1584–91.

    Article  CAS  PubMed  Google Scholar 

  34. Meduri GU et al. Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glucocorticoids. Neuroimmunomodulation 2005; 12: 321–338.

    Article  PubMed  Google Scholar 

  35. Pretorius E et al. Cortisol resistance in conditions such as asthma and the involvement of 11beta-HSD-2: a hypothesis. Horm Metab Res 2006; 38: 368–376.

    Article  CAS  PubMed  Google Scholar 

  36. Hamrahian AH et al. Measurements of serum free cortisol in critically ill patients. N Engl J Med 2004; 350: 1629–1638.

    Article  CAS  PubMed  Google Scholar 

  37. Salgado DR. Adrenal function testing in patients with septic shock. Crit Care 2006; 10: R149.

    Article  PubMed  Google Scholar 

  38. Arafah BM et al. Measurement of Salivary Cortisol Concentration in the Assessment of Adrenal Function in Critically Ill Subjects: A Surrogate Marker of the Circulating Free Cortisol. J Clin Endocrinol Metab 2007; 92: 2965–71.

    Google Scholar 

  39. Chanques G et al. Enlarged adrenals during septic shock. Intensive Care Med. 2007; 33: 1671–2.

    Google Scholar 

  40. Witek-Janusek L et al. Role of the adrenal cortex and medulla in the young rats' glucoregulatory response to endotoxin. Shock 1995; 3: 434–439.

    CAS  PubMed  Google Scholar 

  41. Huang CJ et al. Association between adrenal insufficiency and ventilator weaning. Am J Respir Crit Care Med. 2006; 173: 276–280.

    Article  PubMed  Google Scholar 

  42. Rhen T et al. Antiinflammatory action of glucocorticoids–new mechanisms for old drugs. N Engl J Med. 2005; 353: 1711–1723.

    Article  CAS  PubMed  Google Scholar 

  43. Meduri GU et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome. A randomized controlled trial. JAMA 1998; 280: 159–65.

    Article  CAS  PubMed  Google Scholar 

  44. Confalonieri M et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005; 171: 242–248.

    Article  PubMed  Google Scholar 

  45. Steinberg KP, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006; 354: 1671–1684.

    Article  CAS  PubMed  Google Scholar 

  46. Annane D et al. Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome. Crit Care Med 2006; 34: 22–30.

    Article  CAS  PubMed  Google Scholar 

  47. Meduri GU et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007; 131: 954–963.

    Article  CAS  PubMed  Google Scholar 

  48. Briegel J et al. Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. The Phospholipase A2 Study Group. Clin Investig. 1994; 72: 782–787.

    Article  CAS  PubMed  Google Scholar 

  49. Keh D et al. Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study. Am J Respir Crit Care Med. 2003; 167: 512–520.

    Article  PubMed  Google Scholar 

  50. Oppert M et al. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med. 2005; 33: 2457–2464.

    Article  CAS  PubMed  Google Scholar 

  51. Maxime V et al. Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock. J Infect Dis. 2005; 191: 138–44.

    Article  CAS  PubMed  Google Scholar 

  52. Celik JB et al. Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-alpha, IL-6, IL-8, IL-10. Perfusion. 2004; 19: 185–191.

    Article  PubMed  Google Scholar 

  53. Rivers EP et al. Adrenal insufficiency in high-risk surgical ICU patients. Chest. 2001; 119: 889–896.

    Article  CAS  PubMed  Google Scholar 

  54. Annane et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ. 2004; 329: 480.

    Article  CAS  PubMed  Google Scholar 

  55. McKee JL et al. Cortisol replacement in severely stressed patients. Lancet. 1985 ;1:484.

    Google Scholar 

  56. Bollaert PE et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med. 1998; 26: 645–650.

    Article  CAS  PubMed  Google Scholar 

  57. Chawla K et al. Hydrocortisone reverses refractory septic shock. Crit Care Med 1999; 27: A33.

    Article  Google Scholar 

  58. Annane et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002; 288: 862–871.

    Article  CAS  PubMed  Google Scholar 

  59. Yildiz O et al. Physiological-dose steroid therapy in sepsis. Crit Care 2002; 6: 251–259.

    Article  PubMed  Google Scholar 

  60. Tandan SM et al. Low dose steoids and adrenocortical insufficiency in septic shock: a double-blind randomised controlled trial from India. Am J Respir Crit Care Med 2005; A24.

    Google Scholar 

  61. Rinaldi S et al. Low-dose hydrocortisone during severe sepsis: effects on microalbuminuria. Crit Care Med 2005; 34: 2334–2339.

    Article  Google Scholar 

  62. Huh JW et al. Effect of low doses of hydrocortisone in patient with septic shock and relative adrenal insufficiency: 3 days versus 7 days treatment. Crit Care Med 2007; 34: A101.

    Article  Google Scholar 

  63. Sprung CL et al. The CORTICUS randomized, double-blind, placebo-controlled study of hydrocortisone therapy in patients with septic shock. N Engl J Med 2008; 34: 61–9.

    Google Scholar 

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Authors and Affiliations

  1. Faculté de Médecine, Hôpital Raymond Poincaré (AP-HP), Paris Ile de France Ouest (Université de Versailles Saint Quentin), Garches, France

    Mikael Alves Resident & Djillali Annane MD, PhD

  2. Department of Intensive Care Medicine, Hospital Clinic, Barcelona, Spain

    Xavi Borrat MD

Authors
  1. Mikael Alves Resident
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  2. Xavi Borrat MD
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  3. Djillali Annane MD, PhD
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© 2008 Humana Press a part of Springer Science+Business Media, LLC

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Resident, M.A., Borrat, X., Annane, D. (2008). The Adrenal Response to Critical Illness. In: Acute Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60327-177-6_11

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  • DOI: https://doi.org/10.1007/978-1-60327-177-6_11

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-176-9

  • Online ISBN: 978-1-60327-177-6

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