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Clinical Management of Renal Tumors pp 599–616Cite as

Wilms’ Tumor in Children and Adults

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Abstract

The treatment of Wilms’ tumor represents one of the great achievements in the history of oncology. Named for Max Wilms, who described the tumor in 1899, the prognosis for this most common renal tumor of childhood has steadily improved through innovation and the cooperative efforts of multicenter trials. With nephrectomy alone, 15% of patients could expect to survive in the early 20th century.1 With the advent of radiation therapy, cure rates approached 40%.2 In the latter half of the 20th century, multiagent chemotherapy with vincristine and actinomycin as the mainstays has resulted in cure rates approaching 90% for most Wilms’ tumor patients.3 While multi-center trials have helped define the standard management for Wilms’ tumor, controversies still exist and cure still eludes many patients with high-stage unfavorable histology tumors.

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References

  1. Priestly JT, Shulte TL, The treatment of Wilms’ tumor. Urology 1942;47:7–10.

    Google Scholar 

  2. Ladd WE, White RR. Embryoma of the kidney (Wilms tumor). JAMA 1941;117:1859–1863.

    Google Scholar 

  3. Neville HL, Ritchey ML. Wilms’ tumor: overview of National Wilms’ Tumor Study Group results. Urol Clin North Am 2000;27:435–442.

    Article  PubMed  CAS  Google Scholar 

  4. Farrow GM. Diseases of the kidney. In: Murphy WM, ed. Urological Pathology. Philadelphia: Saunders, 1989:409–482.

    Google Scholar 

  5. Beckwith JB. Wilms tumor and other renal tumors of childhood: an update. J Urol 1986;136:320–324.

    PubMed  CAS  Google Scholar 

  6. Machin GA. Persistent renal blastema (nephroblastomatosis) as a frequent precursor of Wilms’ tumor: a pathological and clinical review (parts 1–3). Am J Pediatr Hematol Oncol 1980;2:165–171, 253–261, 353–362.

    Google Scholar 

  7. Bove DE, McAdams AJ. The nephroblastomatosis complex and its relationship to Wilms’ tumor: a clinicopathologic treatise. In: Rosenberg H, Bolande R, eds. Perspectives in Pediatric Pathology, vol 2. Chicago: Year Book Medical Publishers, 1976:185–223.

    Google Scholar 

  8. Machin GA, McCaughey WTE. A new precursor lesion of Wilms’ tumor (nephroblastoma): intralobar multifocal nephroblastomatosis. Histopathology 1984;8:35–53.

    Article  PubMed  CAS  Google Scholar 

  9. Bergeron C, Iliescu C, Thiesse P, et al. Does nephroblastomatosis influence the natural history and relapse rate in Wilms’ tumour? A single centre experience over 11 years. Eur J Cancer 2001;37:385–391.

    Article  PubMed  CAS  Google Scholar 

  10. Coppes MJ, Arnold M, Beckwith JB, et al. Factors affecting the risk of contralateral Wilms tumor development: a report from the National Wilms Tumor Study Group. Cancer 1999;85:1616–1625.

    Article  PubMed  CAS  Google Scholar 

  11. Hennigar RA, O’Shea PA, Grattan-Smith JD. Clinicopathologic features of nephrogenic rests and nephroblastomatosis. Adv Anat Pathol 2001;8:276–289.

    Article  PubMed  CAS  Google Scholar 

  12. Breslow NE, Beckwith JB. Epidemiological features of Wilms’ tumor: results of the National Wilms’ Tumor Study. J Natl Cancer Inst 1982;68:429–436.

    PubMed  CAS  Google Scholar 

  13. D’Angio GJ, Evans AE, Breslow N, et al. The treatment of Wilms’ tumor: results of the National Wilms’ Tumor Study. Cancer 1976;38:633–646.

    Article  PubMed  Google Scholar 

  14. D’Angio GJ, Evans AE, Breslow N, et al. The treatment of Wilms’ tumor: results of the second National Wilms’ Tumor Study. Cancer 1981;47:2302–2311.

    Article  PubMed  Google Scholar 

  15. D’Angio GJ, Breslow N, Beckwith JB, et al. The treatment of Wilms’ tumor: results of the third National Wilms’ Tumor Study Cancer 1989;64:349–360.

    Article  PubMed  Google Scholar 

  16. Breslow N, Beckwith JB, Ciol M, Sharples K. Age distribution of Wilms’ tumor; report from the National Wilms’ Tumor Study. Cancer Res 1988;15:1653–1657.

    Google Scholar 

  17. Sotelo-Avila C, Gonzalez-Crussi F, Fowler JW. Complete and incomplete forms of Beckwith-Wiedemann syndrome—their oncogenic potential. J Pediatr 1980;96:47–50.

    Article  PubMed  CAS  Google Scholar 

  18. Gallo GE, Chemes HE. The association of Wilms’ tumor, male pseudohermaphroditism and diffuse glomerular disease (Drash syndrome): report of eight cases with clinical and morphologic findings and review of the literature. Pediatr Pathol 1987;7:175–189.

    Article  PubMed  CAS  Google Scholar 

  19. Greenberg F, Stein F, Gresik MV, et al. The Perlman familial nephroblastomatosis syndrome. Am J Med Genet 1986;24:101–110.

    Article  PubMed  CAS  Google Scholar 

  20. Knudson AG Jr. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820–823.

    Article  PubMed  Google Scholar 

  21. Knudson AG Jr, Strong LC. Mutation and cancer: a model for Wilms’ tumor of the kidney. J Natl Cancer Inst 1972;48:313–324.

    PubMed  Google Scholar 

  22. Coppes MJ, Pritchard-Jones K. Principles of Wilms’ tumor biology. Urol Clin North Am 2000;27:423–433.

    Article  PubMed  CAS  Google Scholar 

  23. Wagner KJ, Roberts SG. Transcriptional regulation by the Wilms’ tumour suppressor protein WT1. Biochem Soc Trans 2004;32:932–935.

    Article  PubMed  CAS  Google Scholar 

  24. Little SE, Hanks SP, King-Underwood L, et al. Frequency and heritability of WT1 mutations in non-syndromic Wilms’ tumor patients: a UK Children’s Cancer Study Group Study. J Clin Oncol 2004;22:4140–4146.

    Article  PubMed  CAS  Google Scholar 

  25. Royer-Pokora B, Beier M, Henzler M, et al. Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development. Am J Med Genet 2004;127A:249–257.

    Article  PubMed  Google Scholar 

  26. Ruteshouser EC, Huff V. Familial Wilms tumor. Am J Med Genet 2004;129C:29–34.

    Article  PubMed  Google Scholar 

  27. Grundy PE, Telzerow PE, Breslow N, et al. Loss of heterozygosity for chromosomes 16q and 1p in Wilms’ tumors predicts an adverse outcome. Cancer Res 1994;54:2331.

    PubMed  CAS  Google Scholar 

  28. McNeil DE, Brown M, Ching A, DeBaun MR. Screening for Wilms tumor and hepatoblastoma in children with Beckwith-Wiedemann syndromes: a cost-effective model. Med Pediatr Oncol 2001;37:349–356.

    Article  PubMed  CAS  Google Scholar 

  29. Choyke PL, Siegel MJ, Craft AW, Green DM, DeBaun MR. Screening for Wilms tumor in children with Beckwith-Wiedemann syndrome or idiopathic hemihypertrophy. Med Pediatr Oncol 1999;32:196–200.

    Article  PubMed  CAS  Google Scholar 

  30. Owens CM, Veys PA, Pitchard J, Levitt G, Imeson J, Dicks-Mireaux C. Role of chest computed tomography at diagnosis in the management of Wilms’ tumor: a study by the United Kingdom Children’s Cancer Study Group. J Clin Oncol 2002;20:2768–2773.

    Article  PubMed  CAS  Google Scholar 

  31. Meisel JA, Guthrie KA, Breslow NE, Donaldson SS, Green DM. Significance and management of computed tomography detected pulmonary nodules: a report from the National Wilms Tumor Study Group. Int J Radiat Oncol Biol Physics 1999;44:579–585.

    Article  CAS  Google Scholar 

  32. Wootton-Gorges SL, Albano EA, Riggs JM, Ihrke H, Rumack CM, Strain JD. Chest radiography versus chest CT in the evaluation for pulmonary metastases in patients with Wilms’ tumor: a retro-spective review. Pediatr Radiol 2000;30:533–537.

    Article  PubMed  CAS  Google Scholar 

  33. Leung RS, Liesner R, Brock P. Coagulopathy as a presenting feature of Wilms tumour. Eur J Pediatr 2004;163:369–373.

    Article  PubMed  Google Scholar 

  34. Ritchey ML, Green DM, Breslow NB, et al. Accuracy of current imaging modalities in the diagnosis of synchronous bilateral Wilms’ tumor. Cancer 1995;75:600–604.

    Article  PubMed  CAS  Google Scholar 

  35. Koo AS, Koyle MA, Hurwitz RS, et al. The necessity of contralateral surgical exploration in Wilms tumor with modern noninvasive imaging technique: a reassessment. J Urol 1990;144:416–417.

    PubMed  CAS  Google Scholar 

  36. Goleta-Dy A, Shaw PJ, Stevens MM. Re: The necessity of contralateral surgical exploration in Wilms tumor with modern noninvasive imaging technique: a reassessment [letter]. J Urol 1992;147:171.

    PubMed  CAS  Google Scholar 

  37. Connor JP, Upadhyaya J, Becker C, et al. Contralateral surgical exploration in Wilms tumor: Is it still necessary?. J Urol 1994;151:273A(abstr).

    Google Scholar 

  38. Kessler O, Franco I, Jayabose S, et al. Is contralateral exploration of the kidney necessary in patients with Wilms tumor? J Urol 1996;156:693–695.

    Article  PubMed  CAS  Google Scholar 

  39. Martinez-Ibanez V, de Toledo JS, De Diego M, et al. Wilms’ tumours with intracaval involvement. Med Pediatr Oncol 1996;26:268–271.

    Article  PubMed  CAS  Google Scholar 

  40. Thompson WR, Newman K, Seibel N, et al. A strategy for resection of Wilms’ tumor with vena cava or atrial extension. J Pediatr Surg 1992;27:912–915.

    Article  PubMed  CAS  Google Scholar 

  41. Novick AC, Cosgrove DM. Surgical approach for removal of renal cell carcinoma extending into the vena cava and the right atrium. J Urol 1980;123:947–951.

    PubMed  CAS  Google Scholar 

  42. Montie JE, Jackson CL, Cosgrove DM, et al. Resection of large inferior vena caval thrombi from renal cell carcinoma with the use of circulatory arrest. J Urol 1988;139:25–28.

    PubMed  CAS  Google Scholar 

  43. Pannek J, Goepel M, Kremens B, et al. Surgical management of Wilms’ tumor with intracardiac neoplastic extension. Thorac Cardiovasc Surg 1994;42:108–111.

    Article  PubMed  CAS  Google Scholar 

  44. Schettini ST, da Fonseca JH, Abib SC, et al. Management of Wilms’ tumor with intracardiac extension. Pediatr Surg Int 2000;16:529–532.

    Article  PubMed  CAS  Google Scholar 

  45. Chiappini B, Savini C, Marinelli G, et al. Cavoatrial tumor thrombus: single-stage surgical approach with profound hypothermia and circulatory arrest, including a review of the literature. J Thorac Cardiovasc Surg 2002;124:684–688.

    Article  PubMed  Google Scholar 

  46. Ritchey ML, Kelalis PP, Breslow N, et al. Surgical complications after nephrectomy for Wilms’ tumor. Surg Gynecol Obstet 1992;175:507–514.

    PubMed  CAS  Google Scholar 

  47. Othersen HB Jr, DeLorimer A, Hrabovsky E, et al. Surgical evaluation of lymph node metastases in Wilms’ tumor. J Pediatr Surg 1990;25:330–331.

    Article  PubMed  Google Scholar 

  48. Shamberger RC, Guthrie KA, Ritchey ML, et al. Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4. Ann Surg 1999;229:292–297.

    Article  PubMed  CAS  Google Scholar 

  49. Ritchey ML, Green DM, Thomas PRM, et al. Renal failure in Wilms’ tumor patients: a report from the National Wilms’ Tumor Study Group. Med Pediatr Oncol 1996;26:75–80.

    Article  PubMed  CAS  Google Scholar 

  50. Brenner BM. Nephrology forum: hemodynamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int 1983;23:647–655.

    Article  PubMed  CAS  Google Scholar 

  51. Robson WLM, Leung AKC, Rogers RC. Unilateral renal agenesis. Adv Pediatr 1995;42:575–592.

    PubMed  CAS  Google Scholar 

  52. Rugiu C, Oldrizzi L, Lupo A, et al. Clinical features of patients with solitary kidneys. Nephron 1986;43:10–15.

    Article  PubMed  CAS  Google Scholar 

  53. Argueso LR, Ritchey ML, Boyle ET Jr, et al. Prognosis of children with solitary kidney after unilateral nephrectomy. J Urol 1992;148:747–751.

    PubMed  CAS  Google Scholar 

  54. Argueso LR, Ritchey ML, Boyle ET Jr, et al. Prognosis of patients with unilateral renal agenesis. Pediatr Nephrol 1992;6:412–416.

    Article  PubMed  CAS  Google Scholar 

  55. Di Tullio MT, Casale F, Indolfi P, et al. Compensatory hypertrophy and progressive renal damage in children nephrectomized for Wilms’ tumor. Med Pediatr Oncol 1996;26:325–328.

    Article  PubMed  Google Scholar 

  56. Bailey S, Roberts A, Brock C, et al. Nephrotoxicity in survivors of Wilms’ tumours in the North of England. Brit J Cancer 2002;87:1092–1098.

    Article  PubMed  CAS  Google Scholar 

  57. Donckerwolcke RM, Coppes MJ. Adaptation of renal function after unilateral nephrectomy in children with renal tumors. Pediatr Nephrol 2001;16:568–574.

    Article  PubMed  CAS  Google Scholar 

  58. McLorie GA, McKenna PH, Greenberg M, et al. Reduction in tumor burden allowing partial nephrectomy following preoperative chemotherapy in biopsy proved Wilms tumor. J Urol 1991;146:509–513.

    PubMed  CAS  Google Scholar 

  59. Cozzi F, Schiavetti A, Bonanni M, et al. Enucleative surgery for stage I nephroblastoma with a normal contralateral kidney. J Urol 1996;156:1788–1793.

    Article  PubMed  CAS  Google Scholar 

  60. Moorman-Voestermans CGM, Aronson DC, Staalman CR, et al. Is partial nephrectomy appropriate treatment for unilateral Wilms’ tumor? J Pediatr Surg 1998;33:165–170.

    Article  PubMed  CAS  Google Scholar 

  61. Linni K, Urban C, Lackner H, Hollwarth ME. Nephron-sparing procedures in 11 patients with Wilms’ tumor. Pediatr Surg Int 2003;19:457–462.

    Article  PubMed  CAS  Google Scholar 

  62. Horwitz JR, Ritchey ML, Moksness J, et al. Renal salvage procedures in patients with synchronous bilateral Wilms’ tumors: a report from the National Wilms’ Tumor Study Group. J Pediatr Surg 1996;31:1020–1025.

    Article  PubMed  CAS  Google Scholar 

  63. Haecker FM, von Schweinitz D, Harms D, Buerger D, Graf N. Partial nephrectomy for unilateral Wilms tumor: results of study SIOP 93-01/GPOH. J Urol 2003;170:939–942.

    Article  PubMed  Google Scholar 

  64. Cherullo EE, Ross JH, Kay R, Novick AC. Renal neoplasms in adult survivors of childhood Wilms tumor. J Urol 2001;165:2013–2017.

    Article  PubMed  CAS  Google Scholar 

  65. Williams JA, Magill L, Parham DM, et al. The potential for renal salvage in nonmetastatic unilateral Wilms’ tumor. Am J Pediatr Hematol Oncol 1991;13:342–344.

    Article  Google Scholar 

  66. Zani A, Schiavetti A, Gambino M, Cozzi DA, Conforti A, Cozzi F. Long-term outcome of nephron sparing surgery and simple nephrectomy for unilateral localized Wilms tumor. J Urol 2005;173:946–948.

    Article  PubMed  Google Scholar 

  67. Ritchey ML, Shamberger RC, Haase G, Horwitz J, Bergemann T, Breslow NE. Surgical complications after primary nephrectomy for Wilms’ tumor: report from the National Wilms’ Tumor Study Group. J Am Coll Surg 2001;192:63–68.

    Article  PubMed  CAS  Google Scholar 

  68. Lemerle J, Voute PA, Tournade MF, et al. Preoperative versus postoperative radiotherapy, single versus multiple courses of actinomycin D, in the treatment of Wilms’ tumor: preliminary results of a controlled clinical trial conducted by the International Society of Paediatric Oncology (SIOP). Cancer 1976;38:647–654.

    Article  PubMed  CAS  Google Scholar 

  69. Graf N, Tournade MF, de Kraker J. The role of preoperative chemotherapy in the management of Wilms’ tumor. Urol Clin North Am 2000;27:443–454.

    Article  PubMed  CAS  Google Scholar 

  70. Reinhard H, Aliani S, Ruebe C, Stockle M, Leuschner I, Graf N. Wilms’ tumor in adults: results of the Society of Pediatric Oncology (SIOP) 93-01/Society for Pediatric Oncology and Hematology (GPOH) Study. J Clin Oncol 2004;22:4500–4506.

    Article  PubMed  Google Scholar 

  71. Weirich A, Ludwig R, Graf N, et al. Survival in nephroblastoma treated according to the trial and study SIOP-9/GPOH with respect to relapse and morbidity. Ann Oncol 2004;15:808–820.

    Article  PubMed  CAS  Google Scholar 

  72. Ritchey ML, Kelalis PP, Breslow N, et al. Intracaval and atrial involvement with nephroblastoma: review of National Wilms’ Tumor Study-3. J Urol 1988;140:1113–1118.

    PubMed  CAS  Google Scholar 

  73. Mushtaq I, Carachi R, Roy G, et al. Childhood renal tumours with intravascular extension. Br J Urol 1996;78:772–776.

    PubMed  CAS  Google Scholar 

  74. Ritchey ML, Kelalis PP, Haase GM, et al. Preoperative therapy for intracaval and atrial extension of Wilms’ tumor. Cancer 1993;71:4104–4110.

    Article  PubMed  CAS  Google Scholar 

  75. White JJ, Golladay ES, Kaizer H, et al. Conservatively aggressive management with bilateral Wilms’ tumors. J Pediatr Surg 1976;11:859–865.

    Article  PubMed  CAS  Google Scholar 

  76. Kay R, Tank E. The current management of bilateral Wilms’ tumor. J Urol 1986;135:983–985.

    PubMed  CAS  Google Scholar 

  77. Blute ML, Kelalis PP, Offord KP, et al. Bilateral Wilms’ tumor. J Urol 1987;138:968–973.

    PubMed  CAS  Google Scholar 

  78. Montgomery BT, Kelalis PP, Blute ML, et al. Extended follow up of bilateral Wilms’ tumor: results of the National Wilms’ Tumor Study. J Urol 1991;146:514–518.

    PubMed  CAS  Google Scholar 

  79. Shaul DB, Srikanth MM, Ortega JA, et al. Treatment of bilateral Wilms’ tumor: comparison of initial biopsy and chemotherapy to initial surgical resection in the preservation of renal mass and function. J Pediatr Surg 1992;27:1009–1015.

    Article  PubMed  CAS  Google Scholar 

  80. Tournade MF, Com-Nougue C, de Kraker J, et al. Optimal duration of preoperative therapy in unilateral and nonmetastatic Wilms’ tumor in children older than 6 months: results of the Ninth International Society of Pediatric Oncology Wilms’ Tumor Trial and Study. J Clin Oncol 2001;19:488–500.

    PubMed  CAS  Google Scholar 

  81. Vujanic GM, Kelsey A, Mitchell C, Shannon RS, Gornall P. The role of biopsy in the diagnosis of renal tumors of childhood: results of the UKCCSG Wilms tumor study 3. Med Pediatr Oncol 2003;40:18–22.

    Article  PubMed  Google Scholar 

  82. Ludin A, Macklis RM. Radiotherapy for pediatric genitourinary tumors: its role and long-term consequences. Urol Clin North Am 2000;27:553–562.

    Article  PubMed  CAS  Google Scholar 

  83. Green DM, Breslow NE, Beckwith JB, et al. Treatment with nephrectomy only for small, stage I/favorable histology Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 2001;19:3719–3724.

    PubMed  CAS  Google Scholar 

  84. Green DM, Beslow NE, Li Y, et al. The role of surgical excision in the management of relapsed Wilms’ tumor patients with pulmonary metastases: a report from the National Wilms’ Tumor Study. J Pediatr Surg 1991;26:728–733.

    Article  PubMed  CAS  Google Scholar 

  85. Dome JS, Liu T, Krasin M, et al. Improved survival for patients with recurrent Wilms tumor: the experience at St. Jude Children’s Research Hospital. J Pediatr Hematol Oncol 2002;24:192–198.

    Article  PubMed  Google Scholar 

  86. Green DM. Wilms’ tumour. Eur J Cancer 1997;33:409–418.

    Article  PubMed  CAS  Google Scholar 

  87. Campbell AD, Cohn SL, Reynolds M, et al. Treatment of relapsed Wilms’ tumor with high-dose therapy and autologous hematopoietic stem-cell rescue: the experience at Children’s Memorial Hospital. J Clin Oncol 2004;22:2885–2890.

    Article  PubMed  CAS  Google Scholar 

  88. Kremens B, Gruhn B, Klingebiel T, et al. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone Marrow Transplant 2002;30:893–898.

    Article  PubMed  CAS  Google Scholar 

  89. Abu-Ghosh AM, Krailo MD, Goldman SC, et al. Ifosfamide, carboplatin and etoposide in children with poor-risk relapsed Wilms’ tumor: a Children’s Cancer Group report. Ann Oncol 2002;13:460–469.

    Article  PubMed  CAS  Google Scholar 

  90. Gallego-Melcon S, Sanchez de Toleda J, Doste D, et al. Late recurrent metastasis in Wilms’ tumor. Med Pediatr Oncol 1994;23:158–161.

    Article  PubMed  CAS  Google Scholar 

  91. Green DM, Grigoriev YA, Nan B, et al. Congestive heart failure after treatment for Wilms’ tumor: a report from the National Wilms’ Tumor Study group. J Clin Oncol 2003;21:2447–2448.

    Article  PubMed  Google Scholar 

  92. Hogeboom CJ, Grosser SC, Guthrie KA, Thomas PR, D’Angio GJ, Breslow NE. Stature loss following treatment for Wilms tumor. Med Pediatr Oncol 2001;36:295–304.

    Article  PubMed  CAS  Google Scholar 

  93. Green DM, Peabody EM, Nan B, Peterson S, Kalapurakal JA, Breslow NE. Pregnancy outcome after treatment for Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol 2002;20:2506–2513.

    Article  PubMed  Google Scholar 

  94. Breslow NE, Takashima JR, Whitton JA, et al. Second malignant neoplasms following treatment for Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 1995;13:1851–1859.

    PubMed  CAS  Google Scholar 

  95. Reinhard H, Aliani S, Ruebe C, Stockle M, Leuschner I, Graf N. Wilms’ tumor in adults: results of the Society of Pediatric Oncology (SIOP) 93-01/Society for Pediatric Oncology and Hematology (GPOH) study. J Clin Oncol 2004;22:4500–4506.

    Article  PubMed  Google Scholar 

  96. Williams G, Colbeck RA, Gowing NF. Adult Wilms’ tumour: review of 14 patients. Br J Urol 1992;70:230–235.

    PubMed  CAS  Google Scholar 

  97. Byrd RL, Evans AE, D’Angio GJ. Adult Wilms tumor: effect of combined therapy on survival. J Urol 1982;127:648–651.

    PubMed  CAS  Google Scholar 

  98. Huser J, Grignon DJ, Ro JY, Avala AG, Shannon RL, Papadopoulos NJ. Adult Wilms’ tumor: a clinicopathologic study of 11 cases. Mod Pathol 1990;3:321–326.

    PubMed  CAS  Google Scholar 

  99. Arrigo S, Beckwith JB, D’Angio G, Haase G. Better survival after combined modality care for adults with Wilms’ tumor. Cancer 1990;66:827–830.

    Article  PubMed  CAS  Google Scholar 

  100. Kalapurakal JA, Nan B, Morkool P, et al. Treatment outcomes in adults with favorable histologic type Wilms tumor—an update from the National Wilms Tumor Study Group. Int J Radiat Oncol Biol Phys 2004;60:1379–1384.

    Article  PubMed  Google Scholar 

  101. Terenziani M, Spreafico F, Collini P, et al. Adult Wilms’ tumor: a monoinstitutional experience and a review of the literature. Cancer 2004;101:289–293.

    Article  PubMed  Google Scholar 

  102. Bozeman G, Bissada NK, Abboud MR, Laver J. Adult Wilms’ tumor: prognostic and management considerations. Urology 1995;45:1055–1058.

    Article  PubMed  CAS  Google Scholar 

  103. Ramanthan RK, Rubin JT, Ohori NP, Belani CP. Dramatic response of adult Wilms tumor to paclitaxel and cisplatin. Med Pediatr Oncol 2000;34:296–298.

    Article  Google Scholar 

  104. Green DM, Breslow NE, Beckwith JB, et al. Comparison between single-dose and divided-dose administration of dactinomycin and doxorubicin for patients with Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 1998;16:237–245.

    PubMed  CAS  Google Scholar 

  105. Green DM, Breslow NE, Beckwith JB, et al. Effect of duration of treatment on treatment outcome and cost of treatment for Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 1998;16:3744–3751.

    PubMed  CAS  Google Scholar 

  106. Green DM, Beckwith JB, Breslow NE, et al. Treatment of children with stages II to IV anaplastic Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 1994; 12:2126–2131.

    PubMed  CAS  Google Scholar 

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  1. Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH

    Jonathan H. Ross MD

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  1. Jonathan H. Ross MD
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  1. Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH

    Ronald M. Bukowski MD

  2. Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH

    Andrew C. Novick MD

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Ross, J.H. (2008). Wilms’ Tumor in Children and Adults. In: Bukowski, R.M., Novick, A.C. (eds) Clinical Management of Renal Tumors. Humana Press. https://doi.org/10.1007/978-1-60327-149-3_37

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