Abstract
Renal cell carcinoma as we know today is primarily a surgical disease. The modern era of radical nephrectomy for the treatment of renal cell carcinoma was described by Robson et al.1 The technique of radical nephrectomy can be performed in a variety of ways, but the firm principles outlined by Robson remain relevant today. Robson and associates described removing the kidney with early ligation of the renal artery and vein to minimize tumor emboli, and a lymph node dissection, removing the paraaortic and paracaval nodal packets from the crus of the diaphragm superiorly to the aortic bifurcation inferiorly. Since that time, the technique of radical nephrectomy has undergone some modification, but the general principles outlined remain germane to today’s contemporary practice.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Robson CJ, Churchill BM, Anderson W. The results of radical nephrectomy for renal cell carcinoma. J Urol 1969;101:297.
Turner-Warwick RT. The supracostal approach to the renal area. Br J Urol 1965;37:671–672.
Skinner DG, Vermilion CD, Colvin RB. The surgical management of renal cell carcinoma. J Urol 1972;107:705.
Selli C, Hinshaw WM, Woodard BH, et al. Stratification of risk factors in renal cell carcinoma. Cancer 1983;52:899.
Golimbu M, Joshi P, Sperber A, Tessler A, Al-Askari S, Morales P. Renal cell carcinoma: survival and prognostic factors. Urology 1986;27(4):291–301.
McNichols DW, Segura JW, DeWeerd JH. Renal cell carcinoma: long term survival and late recurrences. J Urol 1981;126:17.
Sagalowsky AI, Kadesky KT, Ewalt DM, Kennedy TJ. Factors influencing adrenal metastasis in renal cell carcinoma. J Urol 1994;151:1181–1184.
Robey EL, Schellhammer PF. The adrenal gland and renal cell carcinoma: is ipsilateral adrenalectomy a necessary component of radical nephrectomy? J Urol 1986;135:453–455.
Winter P, Miersch WD, Vogel J, Jaeger N. On the necessity of adrenal extirpation combined with radical nephrectomy. J Urol 1990;144:842–844.
Tsui KH, Shvarts O, Barbaric Z, Figlin R, deKernion JB, Belldegrun A. Is adrenalectomy a necessary component of radical nephrectomy? UCLA experience with 511 radical nephrectomies. J Urol 2000; 163:437–441.
Peters PC, Brown GL. The role of lymphadenectomy in the management of renal cell carcinoma. Urol Clin North Am 1980;7(3):705–709.
Giuliani L, Giberti C, Martorana G, Rovida S. Radical extensive surgery for renal cell carcinoma: long-term results and prognostic factors. J Urol 1990;143:468–474.
De Kernion JB. Lymphadenectomy for renal cell carcinoma. Urol Clin North Am 1980; 7(3):697–703.
Siminovitch JP, Montie JE, Straffon RA. Lymphadenectomy in renal adenocarcinoma. J Urol 1982;127:1090–1091.
Marshall FF. Lymphadenectomy for renal cell carcinoma. BJU Int 2005;95(suppl 2):34.
Pantuck AJ, Zisman A, Dorey F, et al. Renal cell carcinoma with retroperitoneal lymph nodes. Impact on survival and benefits of immunotherapy. Cancer 2003;97(12):2995–3002.
Kearney GP, Waters WB, Klein LA, Richie JP, Gittes RF. Results of inferior vena cava resection for renal cell carcinoma. J Urol 1981;125:769.
Berg AA. Malignant hypernephroma of the kidney. Its clinical course and diagnosis with a description of the author’s method of radical operative cure. Surg Gynecol Obstet 1913;17:463.
Huang WC, Rhee HK, Mourtzinos AP, et al. Hyponatremia is a potentially serious complication following renal angioinfarction. J Urol 2003;169(4, suppl): abstr 115.
Munro NP, Woodhams S, Nawrocki JD, Fletcher MS, Thomas PJ. The role of transarterial embolization in the treatment of renal cell carcinoma. BJU Int 2003;92:240–244.
Libertino JA, Zinman L, Watkins E. Long term results of resection of renal cell cancer with extension into inferior vena cava. J Urol 1987;137:21–24.
Fitzgerald JM, Tripathy U, Svensson LG, Libertino JA. Radical nephrectomy with vena caval thrombectomy using a minimal access approach for cardiopulmonary bypass. J Urol 1998;159(4):1292–1293.
Wotkowicz C, Libertino JA, Sorcini A, Mourtzinos AP. Management of renal cell carcinoma with vena cava and atrial thrombus: minimal access versus median sternotomy with circulatory arrest. BJU Int 2006;98(2):289–297.
Sogani PC, Herr HW, Rains MS, Whitmore WF. Renal cell carcinoma extending into inferior vena cava. J Urol 1983;130:660–663.
Neves RJ, Zincke H. Surgical treatment of renal cancer with vena cava extension. Br J Urol 1987;59:390–395.
Swierzewski DJ, Swierzewski MJ, Libertino JA. Radical nephrectomy in patients with renal cell carcinoma with venous, vena caval, and atrial extension. Am J Surg 1994;168(2):205–209.
Skinner DG, Pfister RF, Colvin R. Extension of renal cell carcinoma into the vena cava: the rationale for aggressive surgical management. J Urol 1972;107:711.
Naitoh J, Kaplan A, Dorey F, Figlin R, Belldegrun A. Metastatic renal cell carcinoma with concurrent inferior vena caval invasion: long-term survival after combination therapy with radical nephrectomy, vena caval thrombectomy, and postoperative immunotherapy. J Urol 1999;162:46–50.
Suggs WD, Smith RB, Dodson TF, Salam AA, Graham SD. Renal cell carcinoma with inferior vena caval involvement. J Vasc Surg 1991;14:413–418.
Hatcher PA, Anderson EE, Paulson DF, Carson CC, Robertson JE. Surgical management and prognosis of renal cell carcinoma invading the vena cava. J Urol 1991;145:20–24.
Skinner DG, Pritchett TR, Lieskovsky G, Boyd SD, Stiles QR. Vena caval involvement by renal cell carcinoma. Ann Surg 1989;210(3):387–394.
Sosa RE, Muecke EC, Vaughan ED, McCarron JP. Renal cell carcinoma extending into the inferior vena cava: the prognostic significance of the level of vena caval involvement. J Urol 1984;132:1097–1100.
Nesbitt JC, Soltero ER, Cinney CPN, et al. Surgical management of renal cell carcinoma with inferior vena cava tumor thrombus. Ann Thorac Surg 1997;63:1592–1600.
Moinzadeh A, Libertino JA. Prognostic significance of tumor thrombus level in patients with renal cell carcinoma and venous tumor thrombus extension. Is all T3b the same? J Urol 2004;171: 598–601.
Kim HL, Zisman A, Han KR, Figlin RA, Belldegrun A. Prognostic significance of venous thrombus in renal cell carcinoma. Are renal vein and inferior vena cava involvement different? J Urol 2004;171:588–591.
Mattox KL, Feldtman RW, Beall AC, DeBakey ME. Pulmonary embolectomy for massive pulmonary embolism. Ann Surg 1982;195(6):726–731.
Desai MM, Gill IS, Ramani AP, Matin SF, Kaouk JH, Campero JM. Laparoscopic radical nephrectomy for cancer with level I renal vein involvement. J Urol 2003;169:487–491.
Meraney AP, Gill IS, Desai MM, et al. Laparoscopic inferior vena cava and right atrial thrombectomy utilizing deep hypothermic circulatory arrest. J Endourol 2003;17(5):275–282.
Varkarakis IM, Bhayani SB, Allaf ME, Inagaki T, Gonzalgo ML, Jarrett TW. Laparoscopic-assisted nephrectomy with inferior vena cava tumor thrombectomy: preliminary results. Urology 2004;64: 925–929.
Sundaram CP, Rehman J, Landman J, Oh J. Hand assisted laparoscopic radical nephrectomy for renal cell carcinoma with inferior vena caval thrombus. J Urol 2002;168:176–179.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
Chung, B.I., Libertino, J.A. (2008). Radical Nephrectomy. In: Bukowski, R.M., Novick, A.C. (eds) Clinical Management of Renal Tumors. Humana Press. https://doi.org/10.1007/978-1-60327-149-3_11
Download citation
DOI: https://doi.org/10.1007/978-1-60327-149-3_11
Publisher Name: Humana Press
Print ISBN: 978-1-58829-251-3
Online ISBN: 978-1-60327-149-3
eBook Packages: MedicineMedicine (R0)