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Tourette Syndrome and the Spectrum of Neurodevelopmental Tic Disorders

  • Chapter
Hyperkinetic Movement Disorders

Part of the book series: Current Clinical Neurology ((CCNEU))

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Abstract

The first report of a tic disorder was made as early as in 1825 by Jean Marc Gaspard Itard, a French neurologist. He described the case of a French noblewoman, Marquise de Dampierre, who displayed involuntary movements and coprolalia. At the end of the nineteenth century, Armand Trousseau and Georges Gilles de la Tourette published a more complete description of the disorder [1, 2]. In his paper, Gilles de la Tourette described the symptomatology of 9 patients with multiple tics, echolalia, and coprolalia and suggested that it was a neurological condition with a hereditary component. Nevertheless, this syndrome was later considered to be primarily psychogenic in origin, and it is only since the 1960s, with the use of neuroleptics, that the organic basis of Gilles de la Tourette syndrome (TS) has been reaffirmed. TS is now considered a hereditary neuropsychiatric disorder linked to corticostriatal brain circuits.

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References

  1. De La Tourette G. Étude sur une affection nerveuse caractérisée par de l’incoordination motrice accompagnée d’écholalie et de coprolalie. Arch Neurol. 1885;9:19–42.

    Google Scholar 

  2. Rickards H, Woolf I, Cavanna AE. “Trousseau’s disease”: a description of the Gilles de la Tourette syndrome 12 years before 1885. Mov Disord. 2010;25:2285–9.

    Article  PubMed  Google Scholar 

  3. Hornsey H, Banerjee S, Zeitlin H, Robertson M. The prevalence of Tourette syndrome in 13-14-year-olds in mainstream schools. J Child Psychol Psychiatry. 2001;42:1035–9.

    Article  PubMed  CAS  Google Scholar 

  4. Erenberg G, Cruse RP, Rothner AD. Tourette syndrome: an analysis of 200 pediatric and adolescent cases. Cleve Clin Q. 1986;53:127–31.

    PubMed  CAS  Google Scholar 

  5. Banaschewski T, Woerner W, Rothenberger A. Premonitory sensory phenomena and suppressibility of tics in Tourette syndrome: developmental aspects in children and adolescents. Dev Med Child Neurol. 2003;45:700–3.

    Article  PubMed  Google Scholar 

  6. Miguel EC, do Rosario-Campos MC, Prado HS, et al. Sensory phenomena in obsessive-compulsive disorder and Tourette’s disorder. J Clin Psychiatry. 2000;61:150–6.

    Article  PubMed  CAS  Google Scholar 

  7. Kwak C, Dat VK, Jankovic J. Premonitory sensory phenomenon in Tourette’s syndrome. Mov Disord. 2003;18:1530–3.

    Article  PubMed  Google Scholar 

  8. Woods DW, Piacentini J, Himle MB, Chang S. Premonitory Urge for Tics Scale (PUTS): initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disorders. J Dev Behav Pediatr. 2005;26:397–403.

    Article  PubMed  Google Scholar 

  9. Hoekstra PJ, Steenhuis MP, Kallenberg CG, Minderaa RB. Association of small life events with self reports of tic severity in pediatric and adult tic disorder patients: a prospective longitudinal study. J Clin Psychiatry. 2004;65:426–31.

    Article  PubMed  Google Scholar 

  10. Lin H, Katsovich L, Ghebremichael M, et al. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive-compulsive disorder. J Child Psychol Psychiatry. 2007;48:157–66.

    Article  PubMed  Google Scholar 

  11. Woods DW, Watson TS, Wolfe E, Twohig MP, Friman PC. Analyzing the influence of tic-related talk on vocal and motor tics in children with Tourette’s syndrome. J Appl Behav Anal. 2001;34:353–6.

    Article  PubMed  CAS  Google Scholar 

  12. Heinz A. Neurobiological and anthropological aspects of compulsions and rituals. Pharmacopsychiatry. 1999;32:223–9.

    Article  PubMed  CAS  Google Scholar 

  13. Definitions and classification of tic disorders. The Tourette Syndrome Classification Study Group. Arch Neurol. 1993;50:1013–6.

    Article  Google Scholar 

  14. Leckman J, King RA, Cohen DJ. Tics, obsessions, compulsions: developmental psychopathology and clinical care. In: Leckman JF, Cohen DJ, editors. Tics and tic disorders. New York: John Wiley & Sons; 1999. p. 23–42.

    Google Scholar 

  15. Diniz JB, Rosario-Campos MC, Hounie AG, et al. Chronic tics and Tourette syndrome in patients with obsessive-compulsive disorder. J Psychiatr Res. 2006;40:487–93.

    Article  PubMed  Google Scholar 

  16. Saccomani L, Fabiana V, Manuela B, Giambattista R. Tourette syndrome and chronic tics in a sample of children and adolescents. Brain Dev. 2005;27:349–52.

    Article  PubMed  Google Scholar 

  17. Drake Jr ME, Hietter SA, Bogner JE, Andrews JM. Cassette EEG sleep recordings in Gilles de la Tourette syndrome. Clin Electroencephalogr. 1992;23:142–6.

    PubMed  Google Scholar 

  18. Drake Jr ME, Hietter SA, Padamadan H, Bogner JE. Computerized EEG frequency analysis in Gilles de la Tourette syndrome. Clin Electroencephalogr. 1991;22:250–3.

    PubMed  Google Scholar 

  19. Luat AF, Behen ME, Juhasz C, Sood S, Chugani HT. Secondary tics or tourettism associated with a brain tumor. Pediatr Neurol. 2009;41:457–60.

    Article  PubMed  Google Scholar 

  20. Snider LA, Seligman LD, Ketchen BR, et al. Tics and problem behaviors in schoolchildren: prevalence, characterization, and associations. Pediatrics. 2002;110:331–6.

    Article  PubMed  Google Scholar 

  21. Robertson MM. Tourette syndrome, associated conditions and the complexities of treatment. Brain. 2000;123(Pt 3):425–62.

    Article  PubMed  Google Scholar 

  22. Chouinard S, Ford B. Adult onset tic disorders. J Neurol Neurosurg Psychiatry. 2000;68:738–43.

    Article  PubMed  CAS  Google Scholar 

  23. Leckman JF, Zhang H, Vitale A, et al. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics. 1998;102:14–9.

    Article  PubMed  CAS  Google Scholar 

  24. Bloch MH, Leckman JF, Zhu H, Peterson BS. Caudate volumes in childhood predict ­symptom severity in adults with Tourette syndrome. Neurology. 2005;65:1253–8.

    Article  PubMed  Google Scholar 

  25. Pappert EJ, Goetz CG, Louis ED, Blasucci L, Leurgans S. Objective assessments of longitudinal outcome in Gilles de la Tourette’s syndrome. Neurology. 2003;61:936–40.

    Article  PubMed  CAS  Google Scholar 

  26. Bloch MH, Sukhodolsky DG, Leckman JF, Schultz RT. Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette’s syndrome. J Child Psychol Psychiatry. 2006;47:551–9.

    Article  PubMed  Google Scholar 

  27. Gaze C, Kepley HO, Walkup JT. Co-occurring psychiatric disorders in children and adolescents with Tourette syndrome. J Child Neurol. 2006;21:657–64.

    Article  PubMed  Google Scholar 

  28. Pauls DL, Towbin KE, Leckman JF, Zahner GE, Cohen DJ. Gilles de la Tourette’s syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry. 1986;43:1180–2.

    Article  PubMed  CAS  Google Scholar 

  29. Chabane N, Delorme R, Millet B, Mouren MC, Leboyer M, Pauls D. Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern? J Child Psychol Psychiatry. 2005;46:881–7.

    Article  PubMed  Google Scholar 

  30. do Rosario-Campos MC, Leckman JF, Curi M, et al. A family study of early-onset obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2005;136B:92–7.

    Article  PubMed  Google Scholar 

  31. Evans D, Elliott JM, Packard MG. Visual organization and perceptual closure are related to compulsive-like behavior in typically developing children. Merrill Palmer Quarterly. 2001;47:323–35.

    Article  Google Scholar 

  32. Goodman WK, Storch EA, Geffken GR, Murphy TK. Obsessive-compulsive disorder in Tourette syndrome. J Child Neurol. 2006;21:704–14.

    Article  PubMed  Google Scholar 

  33. Goodman WK, Price LH, Rasmussen SA, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989;46:1006–11.

    Article  PubMed  CAS  Google Scholar 

  34. Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA, Baer L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry. 1999;156:1409–16.

    PubMed  CAS  Google Scholar 

  35. Eichstedt JA, Arnold SL. Childhood-onset obsessive-compulsive disorder: a tic-related subtype of OCD? Clin Psychol Rev. 2001;21:137–57.

    Article  PubMed  CAS  Google Scholar 

  36. Shavitt RG, Belotto C, Curi M, et al. Clinical features associated with treatment response in obsessive-compulsive disorder. Compr Psychiatry. 2006;47:276–81.

    Article  PubMed  Google Scholar 

  37. Cath DC, Spinhoven P, Hoogduin CA, et al. Repetitive behaviors in Tourette’s syndrome and OCD with and without tics: what are the differences? Psychiatry Res. 2001;101:171–85.

    Article  PubMed  CAS  Google Scholar 

  38. Cath DC, van de Wetering BJ, van Woerkom TC, Hoogduin CA, Roos RA, Rooijmans HG. Mental play in Gilles de la Tourette’s syndrome and obsessive-compulsive disorder. Br J Psychiatry. 1992;161:542–5.

    Article  PubMed  CAS  Google Scholar 

  39. Swanson JM, Sergeant JA, Taylor E, Sonuga-Barke EJ, Jensen PS, Cantwell DP. Attention-deficit hyperactivity disorder and hyperkinetic disorder. Lancet. 1998;351:429–33.

    Article  PubMed  CAS  Google Scholar 

  40. Peterson BS, Pine DS, Cohen P, Brook JS. Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry. 2001;40:685–95.

    Article  PubMed  CAS  Google Scholar 

  41. Kurlan R, Como PG, Miller B, et al. The behavioral spectrum of tic disorders: a community-based study. Neurology. 2002;59:414–20.

    Article  PubMed  CAS  Google Scholar 

  42. Apter A, Pauls DL, Bleich A, et al. An epidemiologic study of Gilles de la Tourette’s syndrome in Israel. Arch Gen Psychiatry. 1993;50:734–8.

    Article  PubMed  CAS  Google Scholar 

  43. Stewart SE, Illmann C, Geller DA, Leckman JF, King R, Pauls DL. A controlled family study of attention-deficit/hyperactivity disorder and Tourette’s disorder. J Am Acad Child Adolesc Psychiatry. 2006;45:1354–62.

    Article  PubMed  Google Scholar 

  44. Bornstein RA. Neuropsychological performance in children with Tourette’s syndrome. Psychiatry Res. 1990;33:73–81.

    Article  PubMed  CAS  Google Scholar 

  45. Brookshire BL, Butler IJ, Ewing-Cobbs L, Fletcher JM. Neuropsychological characteristics of children with Tourette syndrome: evidence for a nonverbal learning disability? J Clin Exp Neuropsychol. 1994;16:289–302.

    Article  PubMed  CAS  Google Scholar 

  46. Como PG. Neuropsychological function in Tourette syndrome. Adv Neurol. 2001;85:103–11.

    PubMed  CAS  Google Scholar 

  47. Schultz RT, Carter AS, Gladstone M, et al. Visual-motor integration functioning in children with Tourette syndrome. Neuropsychology. 1998;12:134–45.

    Article  PubMed  CAS  Google Scholar 

  48. Harris EL, Schuerholz LJ, Singer HS, et al. Executive function in children with Tourette syndrome and/or attention deficit hyperactivity disorder. J Int Neuropsychol Soc. 1995;1:511–6.

    Article  PubMed  CAS  Google Scholar 

  49. Schuerholz LJ, Singer HS, Denckla MB. Gender study of neuropsychological and neuromotor function in children with Tourette syndrome with and without attention-deficit hyperactivity disorder. J Child Neurol. 1998;13:277–82.

    Article  PubMed  CAS  Google Scholar 

  50. Rowe DC, Stever C, Gard JM, et al. The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behav Genet. 1998;28:215–25.

    Article  PubMed  CAS  Google Scholar 

  51. Sutherland RJ, Kolb B, Schoel WM, Whishaw IQ, Davies D. Neuropsychological assessment of children and adults with Tourette syndrome: a comparison with learning disabilities and schizophrenia. Adv Neurol. 1982;35:311–22.

    PubMed  CAS  Google Scholar 

  52. Yeates KO, Bornstein RA. Neuropsychological correlates of learning disability subtypes in children with Tourette’s syndrome. J Int Neuropsychol Soc. 1996;2:375–82.

    Article  PubMed  CAS  Google Scholar 

  53. Shucard DW, Benedict RH, Tekok-Kilic A, Lichter DG. Slowed reaction time during a ­continuous performance test in children with Tourette’s syndrome. Neuropsychology. 1997;11:147–55.

    Article  PubMed  CAS  Google Scholar 

  54. Keri S, Szlobodnyik C, Benedek G, Janka Z, Gadoros J. Probabilistic classification learning in Tourette syndrome. Neuropsychologia. 2002;40:1356–62.

    Article  PubMed  Google Scholar 

  55. Marsh R, Alexander GM, Packard MG, et al. Habit learning in Tourette syndrome: a translational neuroscience approach to a developmental psychopathology. Arch Gen Psychiatry. 2004;61:1259–68.

    Article  PubMed  Google Scholar 

  56. Marsh R, Alexander GM, Packard MG, Zhu H, Peterson BS. Perceptual-motor skill learning in Gilles de la Tourette syndrome. Evidence for multiple procedural learning and memory systems. Neuropsychologia. 2005;43:1456–65.

    Article  PubMed  Google Scholar 

  57. Budman CL, Bruun RD, Park KS, Lesser M, Olson M. Explosive outbursts in children with Tourette’s disorder. J Am Acad Child Adolesc Psychiatry. 2000;39:1270–6.

    Article  PubMed  CAS  Google Scholar 

  58. Mathews CA, Waller J, Glidden D, et al. Self injurious behaviour in Tourette syndrome: ­correlates with impulsivity and impulse control. J Neurol Neurosurg Psychiatry. 2004;75:1149–55.

    Article  PubMed  CAS  Google Scholar 

  59. Aebi M, Muller UC, Asherson P, et al. Predictability of oppositional defiant disorder and symptom dimensions in children and adolescents with ADHD combined type. Psychol Med. 2010;12:1–12.

    Google Scholar 

  60. Baron-Cohen S, Scahill VL, Izaguirre J, Hornsey H, Robertson MM. The prevalence of Gilles de la Tourette syndrome in children and adolescents with autism: a large scale study. Psychol Med. 1999;29:1151–9.

    Article  PubMed  CAS  Google Scholar 

  61. Canitano R, Vivanti G. Tics and Tourette syndrome in autism spectrum disorders. Autism. 2007;11:19–28.

    Article  PubMed  Google Scholar 

  62. Freeman RD, Fast DK, Burd L, Kerbeshian J, Robertson MM, Sandor P. An international perspective on Tourette syndrome: selected findings from 3,500 individuals in 22 countries. Dev Med Child Neurol. 2000;42:436–47.

    Article  PubMed  CAS  Google Scholar 

  63. Burd L, Li Q, Kerbeshian J, Klug MG, Freeman RD. Tourette syndrome and comorbid pervasive developmental disorders. J Child Neurol. 2009;24:170–5.

    Article  PubMed  Google Scholar 

  64. Coffey BJ, Biederman J, Smoller JW, et al. Anxiety disorders and tic severity in juveniles with Tourette’s disorder. J Am Acad Child Adolesc Psychiatry. 2000;39:562–8.

    Article  PubMed  CAS  Google Scholar 

  65. Comings BG, Comings DE. A controlled study of Tourette syndrome. V. Depression and mania. Am J Hum Genet. 1987;41:804–21.

    PubMed  CAS  Google Scholar 

  66. Kostanecka-Endress T, Banaschewski T, Kinkelbur J, et al. Disturbed sleep in children with Tourette syndrome: a polysomnographic study. J Psychosom Res. 2003;55:23–9.

    Article  PubMed  Google Scholar 

  67. Lesperance P, Robert M, Desjardins M, Sforza, Richer F. Arousal instability in Tourette syndrome. J Psychiatr Clin Neurosci. 2006;18:278 [Abstract].

    Google Scholar 

  68. Fallone G, Acebo C, Seifer R, Carskadon MA. Experimental restriction of sleep opportunity in children: effects on teacher ratings. Sleep. 2005;28:1561–7.

    PubMed  Google Scholar 

  69. Lesperance P, Djerroud N, Diaz AA, Rouleau GA, Chouinard S, Richer F. Restless legs in Tourette syndrome. Mov Disord. 2004;19:1084–7.

    Article  PubMed  CAS  Google Scholar 

  70. Cortese S, Konofal E, Lecendreux M, et al. Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. Sleep. 2005;28:1007–13.

    PubMed  Google Scholar 

  71. Anca MH, Giladi N, Korczyn AD. Ropinirole in Gilles de la Tourette syndrome. Neurology. 2004;62:1626–7.

    Article  PubMed  Google Scholar 

  72. Gilbert DL, Sethuraman G, Sine L, Peters S, Sallee FR. Tourette’s syndrome improvement with pergolide in a randomized, double-blind, crossover trial. Neurology. 2000;54:1310–5.

    Article  PubMed  CAS  Google Scholar 

  73. O’Rourke JA, Scharf JM, Yu D, Pauls DL. The genetics of Tourette syndrome: a review. J Psychosom Res. 2009;67:533–45.

    Article  PubMed  Google Scholar 

  74. Price RA, Kidd KK, Cohen DJ, Pauls DL, Leckman JF. A twin study of Tourette syndrome. Arch Gen Psychiatry. 1985;42:815–20.

    Article  PubMed  CAS  Google Scholar 

  75. Pauls DL, Pakstis AJ, Kurlan R, et al. Segregation and linkage analyses of Tourette’s syndrome and related disorders. J Am Acad Child Adolesc Psychiatry. 1990;29:195–203.

    Article  PubMed  CAS  Google Scholar 

  76. Hyde TM, Aaronson BA, Randolph C, Rickler KC, Weinberger DR. Relationship of birth weight to the phenotypic expression of Gilles de la Tourette’s syndrome in monozygotic twins. Neurology. 1992;42:652–8.

    Article  PubMed  CAS  Google Scholar 

  77. Tourette Syndrome Association International Consortium for Genetics. Genome scan for Tourette disorder in affected-sibling-pair and multigenerational families. Am J Hum Genet. 2007;80:265–72.

    Article  Google Scholar 

  78. Shelley BP, Robertson MM, Turk J. An individual with Gilles de la Tourette syndrome and Smith-Magenis microdeletion syndrome: is chromosome 17p11.2 a candidate region for Tourette syndrome putative susceptibility genes? J Intellect Disabil Res. 2007;51:620–4.

    Article  PubMed  CAS  Google Scholar 

  79. Dehning S, Riedel M, Muller N. Father-to-son transmission of 6;17 translocation in Tourette’s syndrome. Am J Psychiatry. 2008;165:1051–2.

    Article  PubMed  Google Scholar 

  80. Boghosian-Sell L, Comings DE, Overhauser J. Tourette syndrome in a pedigree with a 7;18 translocation: identification of a YAC spanning the translocation breakpoint at 18q22.3. Am J Hum Genet. 1996;59:999–1005.

    PubMed  CAS  Google Scholar 

  81. Kroisel PM, Petek E, Emberger W, Windpassinger C, Wladika W, Wagner K. Candidate region for Gilles de la Tourette syndrome at 7q31. Am J Med Genet. 2001;101:259–61.

    Article  PubMed  CAS  Google Scholar 

  82. Petek E, Windpassinger C, Vincent JB, et al. Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Am J Hum Genet. 2001;68:848–58.

    Article  PubMed  CAS  Google Scholar 

  83. Crawford FC, Ait-Ghezala G, Morris M, et al. Translocation breakpoint in two unrelated Tourette syndrome cases, within a region previously linked to the disorder. Hum Genet. 2003;113:154–61.

    PubMed  CAS  Google Scholar 

  84. Matsumoto N, David DE, Johnson EW, et al. Breakpoint sequences of an 1;8 translocation in a family with Gilles de la Tourette syndrome. Eur J Hum Genet. 2000;8:875–83.

    Article  PubMed  CAS  Google Scholar 

  85. Donnai D. Gene location in Tourette syndrome. Lancet. 1987;1:627.

    Article  PubMed  CAS  Google Scholar 

  86. State MW, Greally JM, Cuker A, et al. Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A. 2003;100:4684–9.

    Article  PubMed  CAS  Google Scholar 

  87. Cuker A, State MW, King RA, Davis N, Ward DC. Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. Am J Med Genet A. 2004;130A:37–9.

    Article  PubMed  Google Scholar 

  88. Walkup JT, LaBuda MC, Singer HS, Brown J, Riddle MA, Hurko O. Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. Am J Hum Genet. 1996;59:684–93.

    PubMed  CAS  Google Scholar 

  89. State MW, Pauls DL, Leckman JF. Tourette’s syndrome and related disorders. Child Adolesc Psychiatr Clin N Am. 2001;10:317–31, ix.

    Google Scholar 

  90. Whitaker AH, Van RR, Feldman JF, et al. Psychiatric outcomes in low-birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities. Arch Gen Psychiatry. 1997;54:847–56.

    Article  PubMed  CAS  Google Scholar 

  91. Peterson BS, Leckman JF, Scahill L, et al. Steroid hormones and CNS sexual dimorphisms modulate symptom expression in Tourette’s syndrome. Psychoneuroendocrinology. 1992;17:553–63.

    Article  PubMed  Google Scholar 

  92. Singer HS, Giuliano JD, Hansen BH, et al. Antibodies against human putamen in children with Tourette syndrome. Neurology. 1998;50:1618–24.

    Article  PubMed  CAS  Google Scholar 

  93. Dale RC. Post-streptococcal autoimmune disorders of the central nervous system. Dev Med Child Neurol. 2005;47:785–91.

    Article  PubMed  Google Scholar 

  94. Morer A, Chae W, Henegariu O, Bothwell AL, Leckman JF, Kawikova I. Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases. Brain Behav Immun. 2010;24:1069–73.

    Article  PubMed  CAS  Google Scholar 

  95. Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry. 1998;155:264–71.

    PubMed  CAS  Google Scholar 

  96. Kurlan R, Kaplan EL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) etiology for tics and obsessive-compulsive symptoms: hypothesis or entity? Practical considerations for the clinician. Pediatrics. 2004;113:883–6.

    Article  PubMed  Google Scholar 

  97. Swedo SE, Leonard HL, Rapoport JL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics. 2004;113:907–11.

    Article  PubMed  Google Scholar 

  98. Gabbay V, Coffey BJ, Babb JS, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic. Pediatrics. 2008;122:273–8.

    Article  PubMed  Google Scholar 

  99. Martino D, Defazio G, Giovannoni G. The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder. J Psychosom Res. 2009;67:547–57.

    Article  PubMed  Google Scholar 

  100. Schrag A, Gilbert R, Giovannoni G, Robertson MM, Metcalfe C, Ben-Shlomo Y. Streptococcal infection, Tourette syndrome, and OCD: is there a connection? Neurology. 2009;73:1256–63.

    Article  PubMed  CAS  Google Scholar 

  101. Kurlan R. Hypothesis II: Tourette’s syndrome is part of a clinical spectrum that includes normal brain development. Arch Neurol. 1994;51:1145–50.

    Article  PubMed  CAS  Google Scholar 

  102. Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol. 1997;387:167–78.

    Article  PubMed  CAS  Google Scholar 

  103. McDonald JW, Johnston MV. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Brain Res Rev. 1990;15:41–70.

    Article  PubMed  Google Scholar 

  104. Beyer C. Estrogen and the developing mammalian brain. Anat Embryol (Berl). 1999;199:379–90.

    Article  CAS  Google Scholar 

  105. Laplane D. Obsessive-compulsive disorders caused by basal ganglia diseases. Rev Neurol (Paris). 1994;150:594–8.

    CAS  Google Scholar 

  106. Demirkol A, Erdem H, Inan L, Yigit A, Guney M. Bilateral globus pallidus lesions in a patient with Tourette syndrome and related disorders. Biol Psychiatry. 1999;46:863–7.

    Article  PubMed  CAS  Google Scholar 

  107. McAbee GN, Wark JE, Manning A. Tourette syndrome associated with unilateral cystic changes in the gyrus rectus. Pediatr Neurol. 1999;20:322–4.

    Article  PubMed  CAS  Google Scholar 

  108. Hyde TM, Stacey ME, Coppola R, Handel SF, Rickler KC, Weinberger DR. Cerebral morphometric abnormalities in Tourette’s syndrome: a quantitative MRI study of monozygotic twins. Neurology. 1995;45:1176–82.

    Article  PubMed  CAS  Google Scholar 

  109. Peterson BS, Thomas P, Kane MJ, et al. Basal Ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry. 2003;60:415–24.

    Article  PubMed  Google Scholar 

  110. Singer HS, Reiss AL, Brown JE, et al. Volumetric MRI changes in basal ganglia of children with Tourette’s syndrome. Neurology. 1993;43:950–6.

    Article  PubMed  CAS  Google Scholar 

  111. Kalanithi PS, Zheng W, Kataoka Y, et al. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proc Natl Acad Sci U S A. 2005;102:13307–12.

    Article  PubMed  CAS  Google Scholar 

  112. Ludolph AG, Juengling FD, Libal G, Ludolph AC, Fegert JM, Kassubek J. Grey-matter abnormalities in boys with Tourette syndrome: magnetic resonance imaging study using optimised voxel-based morphometry. Br J Psychiatry. 2006;188:484–5.

    Article  PubMed  Google Scholar 

  113. Lee JS, Yoo SS, Cho SY, Ock SM, Lim MK, Panych LP. Abnormal thalamic volume in treatment-naive boys with Tourette syndrome. Acta Psychiatr Scand. 2006;113:64–7.

    Article  PubMed  Google Scholar 

  114. Garraux G, Goldfine A, Bohlhalter S, Lerner A, Hanakawa T, Hallett M. Increased midbrain gray matter in Tourette’s syndrome. Ann Neurol. 2006;59:381–5.

    Article  PubMed  Google Scholar 

  115. Haber SN, Kowall NW, Vonsattel JP, Bird ED, Richardson Jr EP. Gilles de la Tourette’s syndrome. A postmortem neuropathological and immunohistochemical study. J Neurol Sci. 1986;75:225–41.

    Article  PubMed  CAS  Google Scholar 

  116. Kataoka Y, Kalanithi PS, Grantz H, et al. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. J Comp Neurol. 2010;518:277–91.

    Article  PubMed  Google Scholar 

  117. Rickards H. Functional neuroimaging in Tourette syndrome. J Psychosom Res. 2009;67:575–84.

    Article  PubMed  Google Scholar 

  118. Braun AR, Stoetter B, Randolph C, et al. The functional neuroanatomy of Tourette’s syndrome: an FDG-PET study. I. Regional changes in cerebral glucose metabolism differentiating patients and controls. Neuropsychopharmacology. 1993;9:277–91.

    PubMed  CAS  Google Scholar 

  119. Diler RS, Reyhanli M, Toros F, Kibar M, Avci A. Tc-99m-ECD SPECT brain imaging in children with Tourette’s syndrome. Yonsei Med J. 2002;43:403–10.

    PubMed  Google Scholar 

  120. Klieger PS, Fett KA, Dimitsopulos T, Kurlan R. Asymmetry of basal ganglia perfusion in Tourette’s syndrome shown by technetium-99m-HMPAO SPECT. J Nucl Med. 1997;38:188–91.

    PubMed  CAS  Google Scholar 

  121. Moriarty J, Costa DC, Schmitz B, Trimble MR, Ell PJ, Robertson MM. Brain perfusion abnormalities in Gilles de la Tourette’s syndrome. Br J Psychiatry. 1995;167:249–54.

    Article  PubMed  CAS  Google Scholar 

  122. Riddle MA, Rasmusson AM, Woods SW, Hoffer PB. SPECT imaging of cerebral blood flow in Tourette syndrome. Adv Neurol. 1992;58:207–11.

    PubMed  CAS  Google Scholar 

  123. Jeffries KJ, Schooler C, Schoenbach C, Herscovitch P, Chase TN, Braun AR. The functional neuroanatomy of Tourette’s syndrome: an FDG PET study III: functional coupling of regional cerebral metabolic rates. Neuropsychopharmacology. 2002;27:92–104.

    Article  PubMed  CAS  Google Scholar 

  124. Braun AR, Randolph C, Stoetter B, et al. The functional neuroanatomy of Tourette’s syndrome: an FDG-PET Study. II: relationships between regional cerebral metabolism and associated behavioral and cognitive features of the illness. Neuropsychopharmacology. 1995;13:151–68.

    Article  PubMed  CAS  Google Scholar 

  125. Crespo-Facorro B, Cabranes JA, Lopez-Ibor Alcocer MI, et al. Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. Eur Arch Psychiatry Clin Neurosci. 1999;249:156–61.

    Article  PubMed  CAS  Google Scholar 

  126. Chase TN, Foster NL, Fedio P, et al. Gilles de la tourette syndrome: studies with the fluorine-18-labeled fluorodeoxyglucose positron emission tomographic method. Ann Neurol. 1984;15(Suppl):S175.

    Article  PubMed  Google Scholar 

  127. Stern E, Silbersweig DA, Chee KY, et al. A functional neuroanatomy of tics in Tourette syndrome. Arch Gen Psychiatry. 2000;57:741–8.

    Article  PubMed  CAS  Google Scholar 

  128. Peterson BS, Skudlarski P, Anderson AW, et al. A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry. 1998;55:326–33.

    Article  PubMed  CAS  Google Scholar 

  129. Biswal B, Ulmer JL, Krippendorf RL, et al. Abnormal cerebral activation associated with a motor task in Tourette syndrome. AJNR Am J Neuroradiol. 1998;19:1509–12.

    PubMed  CAS  Google Scholar 

  130. Wong DF, Singer HS, Brandt J, et al. D2-like dopamine receptor density in Tourette syndrome measured by PET. J Nucl Med. 1997;38:1243–7.

    PubMed  CAS  Google Scholar 

  131. Albin RL, Koeppe RA, Wernette K, et al. Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome. Neurology. 2009;72:1390–6.

    Article  PubMed  CAS  Google Scholar 

  132. Albin RL, Koeppe RA, Bohnen NI, et al. Increased ventral striatal monoaminergic innervation in Tourette syndrome. Neurology. 2003;61:310–5.

    Article  PubMed  CAS  Google Scholar 

  133. Ernst M, Zametkin AJ, Jons PH, Matochik JA, Pascualvaca D, Cohen RM. High presynaptic dopaminergic activity in children with Tourette’s disorder. J Am Acad Child Adolesc Psychiatry. 1999;38:86–94.

    Article  PubMed  CAS  Google Scholar 

  134. Serra-Mestres J, Ring HA, Costa DC, et al. Dopamine transporter binding in Gilles de la Tourette syndrome: a [123I]FP-CIT/SPECT study. Acta Psychiatr Scand. 2004;109:140–6.

    Article  PubMed  CAS  Google Scholar 

  135. Singer HS, Szymanski S, Giuliano J, et al. Elevated intrasynaptic dopamine release in Tourette’s syndrome measured by PET. Am J Psychiatry. 2002;159:1329–36.

    Article  PubMed  Google Scholar 

  136. Cheon KA, Ryu YH, Namkoong K, Kim CH, Kim JJ, Lee JD. Dopamine transporter density of the basal ganglia assessed with [123I]IPT SPECT in drug-naive children with Tourette’s disorder. Psychiatry Res. 2004;130:85–95.

    Article  PubMed  CAS  Google Scholar 

  137. Meyer P, Bohnen NI, Minoshima S, et al. Striatal presynaptic monoaminergic vesicles are not increased in Tourette’s syndrome. Neurology. 1999;53:371–4.

    Article  PubMed  CAS  Google Scholar 

  138. Stamenkovic M, Schindler SD, Asenbaum S, et al. No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette’s disorder patients: a [(123)I]-beta-CIT SPECt-study. Eur Neuropsychopharmacol. 2001;11:69–74.

    Article  PubMed  CAS  Google Scholar 

  139. Muller-Vahl KR, Meyer GJ, Knapp WH, et al. Serotonin transporter binding in Tourette Syndrome. Neurosci Lett. 2005;385:120–5.

    Article  PubMed  CAS  Google Scholar 

  140. Haugbol S, Pinborg LH, Regeur L, et al. Cerebral 5-HT2A receptor binding is increased in patients with Tourette’s syndrome. Int J Neuropsychopharmacol. 2007;10:245–52.

    Article  PubMed  CAS  Google Scholar 

  141. Leckman J. In search of the pathophysiology of Tourette syndrome. In: Bedard M, Agid Y, Chouinard S, Fahn S, Korczyn AD, Lesperance P, editors. Mental and behavioral dysfunction in movement disorders. Totowa: Humana Press; 2003. p. 467–76.

    Chapter  Google Scholar 

  142. Mink JW. Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesis. Pediatr Neurol. 2001;25:190–8.

    Article  PubMed  CAS  Google Scholar 

  143. Groenewegen HJ, van den Heuvel OA, Cath DC, Voorn P, Veltman DJ. Does an imbalance between the dorsal and ventral striatopallidal systems play a role in Tourette’s syndrome? A neuronal circuit approach. Brain Dev. 2003;25 Suppl 1:S3–14.

    Article  PubMed  Google Scholar 

  144. Swerdlow NR, Sutherland AN. Preclinical models relevant to Tourette syndrome. Adv Neurol. 2006;99:69–88.

    PubMed  Google Scholar 

  145. Gilbert DL, Bansal AS, Sethuraman G, et al. Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndrome. Mov Disord. 2004;19:416–25.

    Article  PubMed  Google Scholar 

  146. Orth M, Amann B, Robertson MM, Rothwell JC. Excitability of motor cortex inhibitory ­circuits in Tourette syndrome before and after single dose nicotine. Brain. 2005;128:1292–300.

    Article  PubMed  CAS  Google Scholar 

  147. Greenberg BD, Ziemann U, Cora-Locatelli G, et al. Altered cortical excitability in obsessive-compulsive disorder. Neurology. 2000;54:142–7.

    Article  PubMed  CAS  Google Scholar 

  148. Sheppard DM, Bradshaw JL, Georgiou N, Bradshaw JA, Lee P. Movement sequencing in children with Tourette’s syndrome and attention deficit hyperactivity disorder. Mov Disord. 2000;15:1184–93.

    Article  PubMed  CAS  Google Scholar 

  149. Serrien DJ, Nirkko AC, Loher TJ, Lovblad KO, Burgunder JM, Wiesendanger M. Movement control of manipulative tasks in patients with Gilles de la Tourette syndrome. Brain. 2002;125:290–300.

    Article  PubMed  Google Scholar 

  150. Dursun SM, Burke JG, Reveley MA. Antisaccade eye movement abnormalities in Tourette syndrome: evidence for cortico-striatal network dysfunction? J Psychopharmacol. 2000;14:37–9.

    Article  PubMed  CAS  Google Scholar 

  151. Nomura Y, Fukuda H, Terao Y, Hikosaka O, Segawa M. Abnormalities of voluntary saccades in Gilles de la Tourette’s syndrome: pathophysiological consideration. Brain Dev. 2003;25 Suppl 1:S48–54.

    Article  PubMed  Google Scholar 

  152. Tulen JH, Azzolini M, de Vries JA, Groeneveld WH, Passchier J, van de Wetering BJ. Quantitative study of spontaneous eye blinks and eye tics in Gilles de la Tourette’s syndrome. J Neurol Neurosurg Psychiatry. 1999;67:800–2.

    Article  PubMed  CAS  Google Scholar 

  153. Raffaele R, Rampello L, Vecchio I, et al. Blink reflex abnormalities in children with Tourette syndrome. Eur J Neurol. 2006;13:869–73.

    Article  PubMed  CAS  Google Scholar 

  154. Lemay M, Termoz N, Lesperance P, Chouinard S, Rouleau GA, Richer F. Postural control anomalies in children with Tourette syndrome. Exp Brain Res. 2007;179:525–30.

    Article  PubMed  CAS  Google Scholar 

  155. Sherman EM, Shepard L, Joschko M, Freeman RD. Sustained attention and impulsivity in children with Tourette syndrome: comorbidity and confounds. J Clin Exp Neuropsychol. 1998;20:644–57.

    Article  PubMed  CAS  Google Scholar 

  156. Gilbert D. Treatment of children and adolescents with tics and Tourette syndrome. J Child Neurol. 2006;21:690–700.

    Article  PubMed  Google Scholar 

  157. Bruun RD, Budman CL. Risperidone as a treatment for Tourette’s syndrome. J Clin Psychiatry. 1996;57:29–31.

    PubMed  CAS  Google Scholar 

  158. Scahill L, Leckman JF, Schultz RT, Katsovich L, Peterson BS. A placebo-controlled trial of risperidone in Tourette syndrome. Neurology. 2003;60:1130–5.

    Article  PubMed  CAS  Google Scholar 

  159. Pringsheim T, Pearce M. Complications of antipsychotic therapy in children with tourette syndrome. Pediatr Neurol. 2010;43:17–20.

    Article  PubMed  Google Scholar 

  160. Mukaddes NM, Abali O. Quetiapine treatment of children and adolescents with Tourette’s disorder. J Child Adolesc Psychopharmacol. 2003;13:295–9.

    Article  PubMed  Google Scholar 

  161. Schaller JL, Behar D. Quetiapine treatment of adolescent and child tic disorders. Two case reports. Eur Child Adolesc Psychiatry. 2002;11:196–7.

    Article  PubMed  Google Scholar 

  162. Jankovic J, Glaze DG, Frost Jr JD. Effect of tetrabenazine on tics and sleep of Gilles de la Tourette’s syndrome. Neurology. 1984;34:688–92.

    Article  PubMed  CAS  Google Scholar 

  163. Leckman JF, Hardin MT, Riddle MA, Stevenson J, Ort SI, Cohen DJ. Clonidine treatment of Gilles de la Tourette’s syndrome. Arch Gen Psychiatry. 1991;48:324–8.

    Article  PubMed  CAS  Google Scholar 

  164. Scahill L, Chappell PB, Kim YS, et al. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry. 2001;158:1067–74.

    Article  PubMed  CAS  Google Scholar 

  165. Tourette’s Syndrome Study Group. Treatment of ADHD in children with tics: a randomized controlled trial. Neurology. 2002;58:527–36.

    Article  Google Scholar 

  166. Goetz CG, Tanner CM, Wilson RS, Carroll VS, Como PG, Shannon KM. Clonidine and Gilles de la Tourette’s syndrome: double-blind study using objective rating methods. Ann Neurol. 1987;21:307–10.

    Article  PubMed  CAS  Google Scholar 

  167. Singer HS, Brown J, Quaskey S, Rosenberg LA, Mellits ED, Denckla MB. The treatment of attention-deficit hyperactivity disorder in Tourette’s syndrome: a double-blind placebo-­controlled study with clonidine and desipramine. Pediatrics. 1995;95:74–81.

    PubMed  CAS  Google Scholar 

  168. Shapiro AK, Shapiro E. Controlled study of pimozide vs. placebo in Tourette’s syndrome. J Am Acad Child Psychiatry. 1984;23:161–73.

    Article  PubMed  CAS  Google Scholar 

  169. Micheli F, Gatto M, Lekhuniec E, et al. Treatment of Tourette’s syndrome with calcium antagonists. Clin Neuropharmacol. 1990;13:77–83.

    Article  PubMed  CAS  Google Scholar 

  170. Sandyk R. The effects of naloxone in Tourette’s syndrome. Ann Neurol. 1985;18:367–8.

    Article  PubMed  CAS  Google Scholar 

  171. Muller-Vahl KR, Schneider U, Kolbe H, Emrich HM. Treatment of Tourette’s syndrome with delta-9-tetrahydrocannabinol. Am J Psychiatry. 1999;156:495.

    PubMed  CAS  Google Scholar 

  172. Awaad Y. Tics in Tourette syndrome: new treatment options. J Child Neurol. 1999;14:316–9.

    Article  PubMed  CAS  Google Scholar 

  173. Singer HS, Wendlandt J, Krieger M, Giuliano J. Baclofen treatment in Tourette syndrome: a double-blind, placebo-controlled, crossover trial. Neurology. 2001;56:599–604.

    Article  PubMed  CAS  Google Scholar 

  174. Toren P, Weizman A, Ratner S, Cohen D, Laor N. Ondansetron treatment in Tourette’s disorder: a 3-week, randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2005;66:499–503.

    Article  PubMed  CAS  Google Scholar 

  175. Awaad Y, Michon AM, Minarik S. Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome. Mov Disord. 2005;20:714–8.

    Article  PubMed  Google Scholar 

  176. Martinez-Granero M, Garcia-Perez A, Montanes F. Levetiracetam as an alternative therapy for Tourette syndrome. Neuropsychiatr Dis Treat. 2010;6:309–16.

    Article  PubMed  CAS  Google Scholar 

  177. Hedderick EF, Morris CM, Singer HS. Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome. Pediatr Neurol. 2009;40:420–5.

    Article  PubMed  Google Scholar 

  178. Gilbert DL, Dure L, Sethuraman G, Raab D, Lane J, Sallee FR. Tic reduction with pergolide in a randomized controlled trial in children. Neurology. 2003;60:606–11.

    Article  PubMed  CAS  Google Scholar 

  179. Gonce M, Barbeau A. Seven cases of Gilles de la Tourette’s syndrome: partial relief with clonazepam: a pilot study. Can J Neurol Sci. 1977;4:279–83.

    PubMed  CAS  Google Scholar 

  180. Marras C, Andrews D, Sime E, Lang AE. Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial. Neurology. 2001;56:605–10.

    Article  PubMed  CAS  Google Scholar 

  181. Vincent Jr DA. Botulinum toxin in the management of laryngeal tics. J Voice. 2008;22:251–6.

    Article  PubMed  Google Scholar 

  182. Simpson DM, Blitzer A, Brashear A, et al. Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;70:1699–706.

    Article  PubMed  CAS  Google Scholar 

  183. Himle MB, Woods DW, Piacentini JC, Walkup JT. Brief review of habit reversal training for Tourette syndrome. J Child Neurol. 2006;21:719–25.

    Article  PubMed  Google Scholar 

  184. O’Connor KP, Brault M, Robillard S, Loiselle J, Borgeat F, Stip E. Evaluation of a cognitive-behavioural program for the management of chronic tic and habit disorders. Behav Res Ther. 2001;39:667–81.

    Article  PubMed  Google Scholar 

  185. Deckersbach T, Rauch S, Buhlmann U, Wilhelm S. Habit reversal versus supportive psychotherapy in Tourette’s disorder: a randomized controlled trial and predictors of treatment response. Behav Res Ther. 2006;44:1079–90.

    Article  PubMed  Google Scholar 

  186. Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L. Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry. 2003;160:1175–7.

    Article  PubMed  Google Scholar 

  187. O’Connor KP, Laverdure A, Taillon A, Stip E, Borgeat F, Lavoie M. Cognitive behavioral management of Tourette’s syndrome and chronic tic disorder in medicated and unmedicated samples. Behav Res Ther. 2009;47:1090–5.

    Article  PubMed  Google Scholar 

  188. Temel Y, Visser-Vandewalle V. Surgery in Tourette syndrome. Mov Disord. 2004;19:3–14.

    Article  PubMed  Google Scholar 

  189. Vandewalle V, van der Linden C, Groenewegen HJ, Caemaert J. Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus. Lancet. 1999;353:724.

    Article  PubMed  CAS  Google Scholar 

  190. Shahed J, Poysky J, Kenney C, Simpson R, Jankovic J. GPi deep brain stimulation for Tourette syndrome improves tics and psychiatric comorbidities. Neurology. 2007;68:159–60.

    Article  PubMed  CAS  Google Scholar 

  191. Neimat JS, Patil PG, Lozano AM. Novel surgical therapies for Tourette syndrome. J Child Neurol. 2006;21:715–8.

    Article  PubMed  Google Scholar 

  192. Porta M, Brambilla A, Cavanna AE, et al. Thalamic deep brain stimulation for treatment-refractory Tourette syndrome: two-year outcome. Neurology. 2009;73:1375–80.

    Article  PubMed  CAS  Google Scholar 

  193. Ackermans L, Duits A, Temel Y, et al. Long-term outcome of thalamic deep brain stimulation in two patients with Tourette syndrome. J Neurol Neurosurg Psychiatry. 2010;81:1068–72.

    Article  PubMed  Google Scholar 

  194. Mallet L, Polosan M, Jaafari N, et al. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder. N Engl J Med. 2008;359:2121–34.

    Article  PubMed  CAS  Google Scholar 

  195. Greenberg BD, Gabriels LA, Malone Jr DA, et al. Deep brain stimulation of the ventral internal capsule/ventral striatum for obsessive-compulsive disorder: worldwide experience. Mol Psychiatry. 2010;15:64–79.

    Article  PubMed  CAS  Google Scholar 

  196. Hembree EA, Riggs DS, Kozak MJ, Franklin ME, Foa EB. Long-term efficacy of exposure and ritual prevention therapy and serotonergic medications for obsessive-compulsive disorder. CNS Spectr. 2003;8:363–71, 381.

    Google Scholar 

  197. Dietch JT, Jennings RK. Aggressive dyscontrol in patients treated with benzodiazepines. J Clin Psychiatry. 1988;49:184–8.

    PubMed  CAS  Google Scholar 

  198. American psychiatric association. Practice guideline for the treatment of patients with major depressive disorder. Am J Psychiatry. 2000;157:1–45.

    Google Scholar 

  199. Emslie GJ, Heiligenstein JH, Wagner KD, et al. Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial. J Am Acad Child Adolesc Psychiatry. 2002;41:1205–15.

    Article  PubMed  Google Scholar 

  200. Ipser J, Stein DJ. Systematic review of pharmacotherapy of disruptive behavior disorders in children and adolescents. Psychopharmacology (Berl). 2007;191:127–40.

    Article  CAS  Google Scholar 

  201. Pliszka SR, Crismon ML, Hughes CW, et al. The Texas Children’s Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2006;45:642–57.

    Article  PubMed  Google Scholar 

  202. Bloch MH, Panza KE, Landeros-Weisenberger A, Leckman JF. Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. J Am Acad Child Adolesc Psychiatry. 2009;48:884–93.

    Article  PubMed  Google Scholar 

  203. Chahine LM, Chemali ZN. Restless legs syndrome: a review. CNS Spectr. 2006;11:511–20.

    PubMed  Google Scholar 

  204. Paulus W, Trenkwalder C. Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome. Lancet Neurol. 2006;5:878–86.

    Article  PubMed  CAS  Google Scholar 

  205. Vignatelli L, Billiard M, Clarenbach P, et al. EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. Eur J Neurol. 2006;13:1049–65.

    Article  PubMed  CAS  Google Scholar 

  206. Armour D, Paton C. Melatonin in the treatment of insomnia in children and adolescents. Psychiatrist. 2004;28:222–4.

    Google Scholar 

  207. Faridi K, Suchowersky O. Gilles de la Tourette’s syndrome. Can J Neurol Sci. 2003;30 Suppl 1:S64–71.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Montreal Children’s Hospital, Montreal, QC, Canada, H3H 1P3

    Geneviève Bernard MD, MSc, FRCPC

  2. CHUM-Notre-Dame Hospital, Montreal, QC, Canada, H2L 4M1

    Paul Lespérance MD & Sylvain Chouinard MD, FRCPC

  3. Department of Psychology, UQAM, Montreal, QC, Canada, H3C 3P8

    Francois Richer PhD

Authors
  1. Geneviève Bernard MD, MSc, FRCPC
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  2. Paul Lespérance MD
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  3. Francois Richer PhD
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  4. Sylvain Chouinard MD, FRCPC
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Correspondence to Geneviève Bernard MD, MSc, FRCPC .

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Editors and Affiliations

  1. Department of Medicine (Neurology) and Medical Genetics, University of Alberta, Edmonton, AB, Canada

    Oksana Suchowersky

  2. Department of Neurology, Rush University Medical Center, Chicago, IL, USA

    Cynthia Comella

Electronic Supplementary material

CASE 1 - Gilles de la Tourette’s syndrome: Simple motor tics (wmv 17,940 KB)

CASE 2 - Gilles de la Tourette’s syndrome: Vocal tics (wmv 1,762 KB)

CASE 3 - Gilles de la Tourette’s syndrome: Coprolalia (wmv 45,010 KB)

CASE 4A - Gilles de la Tourette’s syndrome: Multiple motor and vocal tics (wmv 54,967 KB)

CASE 4B - Gilles de la Tourette’s syndrome: Suppressibility and urge (wmv 21,271 KB)

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Bernard, G., Lespérance, P., Richer, F., Chouinard, S. (2012). Tourette Syndrome and the Spectrum of Neurodevelopmental Tic Disorders. In: Suchowersky, O., Comella, C. (eds) Hyperkinetic Movement Disorders. Current Clinical Neurology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-120-2_4

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