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Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease

An Epidemiological Perspective

  • Chapter
The Metabolic Syndrome

Part of the book series: Contemporary Endocrinology ((COE))

  • 1547 Accesses

Abstract

Insulin resistance has been defined as a state (of a cell, tissue, system, or body) in which greater-than-normal amounts of insulin are required to elicit a quantitatively normal response (1). The list of adverse events to which insulin resistance potentially contributes has grown as researchers have examined the critical links underlying these relationships. One of the most important of these is the increased risk from cardiovascular disease. The link between concentrations of insulin and coronary heart disease was first made in the late 1960s (2). Since then, a solid body of evidence that supports insulin resistance syndrome as a risk factor for cardiovascular disease has accumulated. In this chapter, the epidemiologic evidence linking insulin resistance to cardiovascular disease will be reviewed. The focus will be on prospective studies of mostly population samples.

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Authors and Affiliations

  1. Centers for Disease Control, Atlanta, GA

    Earl S. Ford MD, MPH (Senior Scientist)

  2. Harvard Medical School and School of Public Health, Boston, MA

    Simin Liu MD, MPH, MS, SeD (Professor of Medicine and Epidemiology)

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  1. Earl S. Ford MD, MPH
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Editors and Affiliations

  1. Obesity, Diabetes, and Aging Research Center, University of South Florida College of Medicine, Tampa, FL

    Barbara Caleen Hansen PhD (Professor of Internal Medicine and Pediatrics Director) (Professor of Internal Medicine and Pediatrics Director)

  2. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA

    George A. Bray MD (Boyd Professor) (Boyd Professor)

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Ford, E.S., Liu, S. (2008). Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease. In: Hansen, B.C., Bray, G.A. (eds) The Metabolic Syndrome. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-60327-116-5_5

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