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Toward the Realization of the Promise of Microarrays in Oncology

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Book cover Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Part of the book series: Cancer Drug Discovery and Development™ ((CDD&D))

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Summary

Microarrays have long been promised to be a tool that might one day revolutionize oncology research and drug development. Despite the tremendous potential, however, there have been few breakthroughs that can be directly attributed to microarray-based profiling. While many researchers now say that microarrays have been over-hyped, it is more likely that early experiments were simply conducted in a naïve manner. Many believe that as technology and our understanding of experimental design improves, so too will the end results. We believe that with new approaches, particularly the use of pure cell populations potentially coupled with new and improved RNA amplification methodologies, the promise of microarrays for oncology finally will be realized.

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Author information

Authors and Affiliations

  1. UHN Microarray Centre, University Health Network T. Robert Beamish Family Convergence Centre of Medical Discovery Toronto, Ontario, Canada

    Natalie Stickle MSc & Neil Winegarden MSc

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  1. Natalie Stickle MSc
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  2. Neil Winegarden MSc
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Editors and Affiliations

  1. Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637-1470, USA

    Federico Innocenti

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Stickle, N., Winegarden, N. (2008). Toward the Realization of the Promise of Microarrays in Oncology. In: Innocenti, F. (eds) Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response. Cancer Drug Discovery and Development™. Humana Press. https://doi.org/10.1007/978-1-60327-088-5_1

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