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Comorbid Depression and Diabetes

Natural History and Clinical Aspects

  • Chapter
Controversies in Treating Diabetes

Part of the book series: Contemporary Endocrinology ((COE))

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Summary

Depression, the leading cause of disability in the world, is more common in patients with diabetes, and it is associated with negative outcomes in these patients. These negative outcomes include less adherence to treatment recommendations, higher blood glucose levels, higher rates of microvascular and macrovascular complications, lower rates of productivity at work, higher health care costs, and higher mortality rates.

This chapter addresses two key issues concerning comorbid depression and type 2 diabetes: 1) why depression is more common in patients with type 2 diabetes, and 2) whether relieving depression in patients with diabetes improves clinical and other outcomes. It appears that depression is a risk factor for developing type 2 diabetes, while having type 2 diabetes does not seem to increase the risk of becoming depressed. Depression may increase diabetes risk via behavioral and/or psychoneurolhormonal pathways. Depression treatment is effective in relieving depression in patients with diabetes, and it can improve glycemic control in those whose control is poor. This treatment can also improve work productivity and reduce health care costs.

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  1. Richard R. Rubin PhD
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Editors and Affiliations

  1. Division of Endocrinology, Diabetes, and Bone Disease, Department of Medicine, Mount Sinai School of Medicine, New York, NY

    Derek LeRoith MD PhD

  2. Diabetes Research Institute Department of Medicine, Eastern Virginia Medical School The Leonard Strelitz Diabetes Institutes, Norfolk, VA

    Aaron I. Vinik MD PhD FCP FACP

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Rubin, R.R. (2008). Comorbid Depression and Diabetes. In: LeRoith, D., Vinik, A.I. (eds) Controversies in Treating Diabetes. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-572-5_17

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