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Chronic Viral Hepatitis pp 1–31Cite as

Molecular Virology of Hepatitis B and C: Clinical Implications

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Part of the book series: Clinical Gastroenterology ((CG))

Abstract

Key Principles

HBV and HCV are hepatotropic, noncytotoxic viruses.

Both viruses mutate rapidly to produce quasispecies.

HBV, but not HCV, can integrate into the host genome.

Both viruses require viral and host proteins for replication.

Few animal models for HBV and HCV are available.

Specialized features of viral replication may offer targets for new antiviral agents.

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Acknowledgments

The support of the grant NIDDK-42182 from NIH, the Herman Lopata Chair in Hepatitis Research, is gratefully acknowledged.

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Authors and Affiliations

  1. University of Connecticut Health Center, Farmington, CT, USA

    Marcy Coash MD & George Y. Wu MD, PhD

Authors
  1. Marcy Coash MD
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  2. George Y. Wu MD, PhD
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Editor information

Editors and Affiliations

  1. Department of Hepatology, Georgetown University Hospital, Reservoir Road GUH 3800, Washington, 20007, U.S.A.

    Kirti Shetty

  2. University of Connecticut Health Center, Farmington Ave. 236, Farmington, 06030-1845, U.S.A.

    George Y. Wu

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Coash, M., Wu, G.Y. (2009). Molecular Virology of Hepatitis B and C: Clinical Implications. In: Shetty, K., Wu, G. (eds) Chronic Viral Hepatitis. Clinical Gastroenterology. Humana Press. https://doi.org/10.1007/978-1-59745-565-7_1

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  • DOI: https://doi.org/10.1007/978-1-59745-565-7_1

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-934115-81-7

  • Online ISBN: 978-1-59745-565-7

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