Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Barlogie B, Hall R, Zander A et al. High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood 1986; 67: 1298–1301.
Barlogie B, Alexanian R, Dicke KA et al. High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma. Blood 1987; 70: 869–872.
Attal M, Harousseau JL, Stoppa AM et al. For the Intergroupe Français du Myelome. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. N Engl J Med 1996; 335: 91–97.
Child JA, Morgan GJ, Davies FE et al. Medical research council adult leukemia working party: High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003; 348: 1875–1883.
Fermand JP, Ravaud P, Chevret S et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: Up-front or rescue treatment? Results of a multicenter sequential randomized trial. Blood 1998; 92: 3131–3136.
Fermand JP, Katsahian S, Divine M et al. High-dose therapy and autologous blood stem cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: Long-term results of a randomized control trial from the Groupe Myelome-Autogreffe. J Clin Oncol 2005; 23: 9227–9233.
Blade J, Samson D, Reece D et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haematopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol 1998; 102: 1115–1123.
Durie BG, Harousseau JL, Miguel JS et al. International uniform response criteria for multiple myeloma. Leukemia 2006; 20: 1467–1473.
Blade J, Rosinol L, Sureda A et al. High-dose therapy intensification compared with continued standard chemotherapy in multiple myeloma patients responding to the initial chemotherapy: Long-term results from a prospective randomized trial from the Spanish cooperative groupe PETHEMA. Blood 2005; 106: 3755–3759.
Barlogie B, Kyle RA, Anderson KC et al. Standard chemotherapy compared with high dose chemoradiotherapy for multiple myeloma: Final results of phase III US Intergroup Trial S9321. J Clin Oncol 2006; 24: 929–936.
Alexanian R, Dimopoulos MA, Hester J et al. Early myeloablative therapy for multiple myeloma. Blood 1994; 84: 4278–4282.
Kumar S, Lacy MQ, Dispenzieri A et al. High-dose therapy and autologous stem cell transplantation for multiple myeloma poorly responsive to initial therapy. Bone Marrow Transplant 2004; 34: 161–167.
Harousseau JL, Milpied N, Laporte JP et al. Double-intensive therapy in high-risk multiple myeloma. Blood 1992; 79: 3131–3136.
Barlogie B, Jagannath S, Desikan KR et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood 1999; 93: 55–65.
Attal M, Harousseau JL, Facon T et al. Intergroupe Francophone du Myelome: Single versus double autologous stem cell transplantation for multiple myeloma. N Engl J Med 2003; 349: 2495–2502.
Cavo M, Tosi P, Zamagni E et al. Prospective randomized study of single compared with double autologous stem cell transplantation for multiple myeloma: Bologna 96 clinical study. J. Clin Oncol 2007; 25: 2434–2441.
Sonneveld P, Van Der Holt B, Segeren CM et al. Intermediate-dose melphalan compared with myeloablative treatment in multiple myeloma: Long-term follow-up of the Deutch Cooperative Group HOVaN 24 trial. Haematologica 2007; 92: 928–935.
Barlogie B, Tricot G, Rabmussen E et al. Total therapy 2 without thalidomide in comparison with total therapy 1: Role of intensified induction and post-transplantation consolidation therapies. Blood 2006; 107: 2633–2638.
Moreau P, Hullin C, Garban F et al. Tandem autologous stem cell transplantation in high risk de novo multiple myeloma: Final results of the prospective and randomized IFM 99-04 protocol. Blood 2006; 107: 397–403.
Rajkumar V, Blaad E, Vesole D et al. Phase III clinical trial of Thalidomide plus Dexamethasone compared with Dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006; 24: 431–436.
Cava M, Zamagni E, Tosi P et al. Superiority of thalidomide and dexamethasone over vincristine-doxorubicine-dexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Blood 2005; 106: 35–39.
Goldschmidt H, Sonneveld P, Breitkreuz I et al. HOVON 50/GMMG-HD3 trial: Phase III study on the effect of thalidomide combined with high-dose melphalan in myeloma patients up to 65 years. Blood 2005; 106: 128a (abstract).
Macro M, Divine M, Uzunban Y et al. Dexamethasone + thalidomide compared to VAD as pre-transplant treatment in newly diagnosed multiple myeloma: A randomized trial. Blood 2006; 108: 22a (abstract).
Jagannath S, Durie B, Wolf J et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 2005; 129: 776–783.
Oakervee HE, PoHat R, Curry N et al. PAD combination therapy (PS34l, doxoru-bicin and dexamethasone) for untreated multiple myeloma. Br J Haematol 2005; 755–762.
Popat R, Oakervee HE, Curry N et al. Reduced dose PAD (PS 341, adriamycin and dexamethasone) for previously untreated patients with multiple myeloma. Blood 2005; 106: 717a (abstract).
Harousseau JL, Attal M. Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma. Haematologica 2006; 91: 1498–1505.
Barlogie B, Tricot G, Rasmussen E et al. Total therapy incorporating Velcade into upfront management of multiple myeloma: Comparison with TT2+thalidomide. Blood 2005; 106: 337a (abstract).
Wang M, Delaballe K, Giralt S et al. Rapid control of previously untreated multiple myeloma with bortezomib-thalidomide-dexamethasone followed by early intensive therapy. Blood 2005; 106: 231a (abstract).
Rajkumar SV, Hayman SR, Lacy MQ et al. Combination therapy with lenalidomide plus dexamethasone for newly diagnosed myeloma. Blood 2005; 106: 4050–4053.
Attal M, Harousseau JL, Leyvras S et al. Maintenance therapy with thalidomide improves survival in multiple myeloma patients. Blood 2006: 15: 3289–3294.
Spencer A, Prince M, Roberts AW et al. First analysis of the Australian leukaemia and lymphoma group trial of thalidomide and alternate day prednisone following autologous stem cell transplantation for patients with multiple myeloma. Blood 2006; 108: 22a (abstract).
Barlogie B, Tricot G, Anaissie E et al. Thalidomide and hematopoietic cell transplantation for multiple myeloma. N Engl J Med 2006; 354: 1021–1030.
Siegel DS, Desikan KR, Nehta J et al. Age is not a prognostic variable with autotransplants for multiple myeloma. Blood 1999; 93: 51–54.
Badros A, Barlogie B, Siegel E et al. Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years. Br J Haematol 2001; 114: 600–607.
Palumbo A, Triolo S, Argentin C. Dose intensive melphalan with stem-cell support is superior to standard treatment in elderly myeloma patients. Blood 1999; 94: 1248–1253.
Palumbo A, Bringhen S, Petrucci MT et al. Intermediate-dose Melphalan improves survival of myeloma patients aged 50–70: Results of a randomized controlled trial. Blood; 2004: 3052–3057.
Facon T, Mary JY, Hulin C et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99–06): a randomised trial. Lancet 2007; 370: 1209–1218
Badros A, Barlogie B, Siegel E et al. Results of autologous stem cell transplant in multiple myeloma patients with renal failure. Br J Haematol 2001; 114: 822–829.
Tosi P, Zamagni E, Ronconi S et al. Safety of autologous hematopoietic stem cell transplantation in patients with multiple myeloma and renal failure. Leukemia 2000; 14: 1310–1313.
San Miguel J, Lahuerta JJ, Garcia-Sanz R et al. Are myeloma patients with renal failure candidate for autologous stem cell transplantation. Hematol J 2000; 1: 28–36.
Barlogie B, Jagannath S, Desikan KR et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood 1999; 93: 66–75.
Vesole D, Tricot G, Jagannath S et al. Autotransplant in multiple myeloma: What have we learned? Blood 1996; 88: 838–847.
Facon T, Avet-Loiseau H, Guillerm G et al. Chromosome 13 abnormalities identified by Fish analysis and serum B2 microglobulin produce powerful myeloma staging system for patients receiving high-dose therapy. Blood 2001; 97: 1566–1571.
Tricot G, Spencer T, Sawyer J et al. Predicting long-term (~5 years) event-free survival in multiple myeloma patients following planned tandem autotransplant. Br J Haematol 2002; 116: 211–217.
Shaughnessy J, Jacobson J, Sawyer J et al. Continuous absence of metaphase-defined cytogenetic abnormalities especially of chromosome 13 and hypodiploidy ensures long-term survival in multiple myeloma treated with Total Therapy I: Interpretation in the context of global gene expression. Blood 2003; 101: 3849–3856.
Fassas AT, Spencer T, Sawyer J et al. Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma. Br J Haematol 2002; 118: 1041–1047.
Chang H, Sloan S, Li D et al. The t(4;14) is associated with poor prognosis in myeloma patients undergoing autologous stem cell transplant. Br J Haematol 2004; 125: 64–68.
Gertz M, Lacy MQ, Dispenzieri A et al. Clinical implications of t(11;14) (q13;q32), t(4;14) (p16.3;q32), and 17p13 in myeloma patients treated with high-dose therapy. Blood 2005; 106: 2837–2840.
Jaksic W, Trudel S, Chang H et al. Clinical outcomes in t(4;14) multiple myeloma: A chemotherapy-sensitive disease characterized by rapid relapse and alkylating agent resistance. J Clin Oncol 2005; 23: 7069–7073.
Chang H, Qi C, Yi QL et al. p53 gene deletion detected by fluorescence in situ hybridisation is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Blood 2005; 105: 358–360.
Avet-Loiseau H, Attal M, Moreau P et al. Genetic abnormalities and survival in multiple myeloma: The experience of the Intergroupe Francophone du Myelome. Blood 2007; 109: 3489–3495.
Palumbo A, Bringhen S, Caravita T et al. Oral Melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: Randomised controlled trial. Lancet 2006; 367: 825–831.
Mateos MV, Hernandez JM, Gutierrez WC et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: Results of a mul-ticenter phase l/II study. Blood 2006, online.
Palumbo A, Falco P, Falcone A et al. Oral revlimid plus melphalan and prednisone for newly diagnosed multiple myeloma: Results of a multicenter phase l/II study. Blood 2006; online.
Lacy M, Gertz M, Dispenzieri A et al. Lenalidomide plus dexamethasone in newly diagnosed myeloma: Response to therapy, time to progression and survival Lancet 2006; 367: 825–831.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Harousseau, JL. (2008). Role of Autologous Stem Cell Transplantation in Multiple Myeloma. In: Lonial, S. (eds) Myeloma Therapy. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-564-0_6
Download citation
DOI: https://doi.org/10.1007/978-1-59745-564-0_6
Publisher Name: Humana Press
Print ISBN: 978-1-934115-82-4
Online ISBN: 978-1-59745-564-0
eBook Packages: MedicineMedicine (R0)