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Macromolecular Drug Delivery

  • Chapter
Biopharmaceutical Drug Design and Development

Abstract

Advances in molecular biotechnology coupled with novel technologies such as combinatorial chemistry and high-throughput screening have led to the discovery of a large number of drugs with macromolecular properties. Macromolecular therapeutics encompasses a variety of approaches including recombinant proteins, genes, antisense, and small interfering RNAs, all of which have larger molecular dimensions than conventional drugs. These macromolecules have emerged as a powerful class of drugs for a wide range of therapeutic indications mainly on the basis of their site-specific activity and reduced side effects. However, these drugs present an enormous challenge for noninvasive delivery as they are poorly absorbed and rapidly metabolized in the body. To surmount these obstacles, either the other aspects of the drug may be exploited or novel delivery systems may be developed. Cost-effectiveness suggests that developing an improved delivery system for an existing drug is a better alternative than modifying the chemical structure of the drug or discovering new drug entities. This chapter focuses on macromolecular drugs and their delivery systems including liposomes, polymers, peptides, and nanoparticles.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV

    Neelam Azad

  2. Department of Basic Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV

    Yon Rojanasakul PhD

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  1. Neelam Azad
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  1. Pharmaceutical Sciences Graduate Programs Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA

    Susanna Wu-Pong PhD (Director) (Director)

  2. Virginia Commonwealth University, Box 980581, Medical College of Virginia Campus, Richmond, VA, 23298

    Susanna Wu-Pong PhD (Director) (Director)

  3. Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV

    Yon Rojanasakul PhD (Professor of Pharmaceutical and Pharmacological Sciences) (Professor of Pharmaceutical and Pharmacological Sciences)

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Azad, N., Rojanasakul, Y. (2008). Macromolecular Drug Delivery. In: Wu-Pong, S., Rojanasakul, Y. (eds) Biopharmaceutical Drug Design and Development. Humana Press. https://doi.org/10.1007/978-1-59745-532-9_14

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