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Autoimmune Diseases in Transplanted Livers

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Liver Immunology

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Abstract

Liver transplantation (LT) is a standard therapeutic approach for the treatment of end-stage acute and chronic liver disease of various etiologies including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). Results of LT for these autoimmune liver diseases are good, with a patient survival of 80 to 85% at 5 yr after LT. Transplant recipients, however, experience various complications, such as acute and chronic rejection, recurrence of disease, and chronic hepatitis. Recurrence of disease on the graft may be influenced by the genetic background of the recipient as well as other factors such as the degree of immunosuppression. Interestingly, autoimmunity and autoimmune disease can occur de novo following LT even for non-autoimmune liver diseases. However, the mechanisms that lead to autoimmunity or recurrence of autoimmune liver diseases after LT have not yet been defined. This chapter focuses on recurrence and occurrence of autoimmune diseases in transplanted livers.

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Author information

Authors and Affiliations

  1. Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center, Japan

    Hiromi Ishibashi MD & Minoru Nakamura MD

  2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasakim, Japan

    Hiromi Ishibashi MD & Minoru Nakamura MD

  3. Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Shinji Shimoda MD

Authors
  1. Hiromi Ishibashi MD
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  2. Shinji Shimoda MD
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  3. Minoru Nakamura MD
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  4. M. Eric Gershwin
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Editor information

Editors and Affiliations

  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

    M. Eric Gershwin MD, FACP

  2. Departments of Medicine and Surgery Baylor Liver Health, Baylor College of Medicine, Houston, TX

    John M. Vierling MD, FACP

  3. Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany

    Michael P. Manns MD

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© 2007 Humana Press Inc., Totowa, NJ

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Ishibashi, H., Shimoda, S., Nakamura, M., Eric Gershwin, M. (2007). Autoimmune Diseases in Transplanted Livers. In: Gershwin, M.E., Vierling, J.M., Manns, M.P. (eds) Liver Immunology. Humana Press. https://doi.org/10.1007/978-1-59745-518-3_35

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  • DOI: https://doi.org/10.1007/978-1-59745-518-3_35

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-818-8

  • Online ISBN: 978-1-59745-518-3

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