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Liver Immunology pp 25–39Cite as

Role and Function of Liver Sinusoidal Endothelial Cells

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Abstract

The liver holds a unique position with regard to the blood circulation. It receives venous blood draining from almost the entire gastrointestinal tract via the portal vein and from the systemic circulation via the hepatic artery. More than 2000 L of blood stream daily through the human liver, and peripheral blood leukocytes pass through the liver on average more than 300 times per day. These simple facts clearly demonstrate that the liver is a “meeting point” for antigens and leukocytes circulating in the blood.

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  1. Institute for Molecular Medicine and Experimental Immunology, University Hospital Bonn, Bonn, Germany

    Percy A. Knolle MD

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  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

    M. Eric Gershwin MD, FACP

  2. Departments of Medicine and Surgery Baylor Liver Health, Baylor College of Medicine, Houston, TX

    John M. Vierling MD, FACP

  3. Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany

    Michael P. Manns MD

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Knolle, P.A. (2007). Role and Function of Liver Sinusoidal Endothelial Cells. In: Gershwin, M.E., Vierling, J.M., Manns, M.P. (eds) Liver Immunology. Humana Press. https://doi.org/10.1007/978-1-59745-518-3_3

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  • DOI: https://doi.org/10.1007/978-1-59745-518-3_3

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