Abstract
Hepatitis A, B, and C virus (HAV, HBV, and HCV) infections can be associated with various extrahepatic manifestations, which can be seen in both acute and chronic infections. Extrahepatic manifestations in acute hepatitis are often seen in hepatitis B, less often in hepatitis C, and only occasionally in hepatitis A. Clinically important extrahepatic manifestations are most often seen in chronic hepatitis C infection. Therefore some of the causative pathomechanisms are explained in more detail for HCV, e.g., the autoimmune syndromes and cryoglobulinemia.
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Beyazit Y, Guven GS, Kekilli M, Koklu S, Yolcu OF, Shorbagi A. Acute pericarditis and renal failure complicating acute hepatitis A infection. South Med J 2006; 99: 82–84.
Schiff ER. Atypical clinical manifestations of hepatitis A. Vaccine 1992; 10(Suppl 1):S18–20.
Eng C, Chopra S. Acute renal failure in nonfulminant hepatitis A. J Clin Gastroenterol 1990; 12:717–718.
Chio F Jr, Bakir AA. Acute renal failure in hepatitis A. Int J Artif Organs 1992; 15:413–416.
Geltner D, Naot Y, Zimhoni O, Gorbach S, Bar-Khayim Y. Acute oliguric renal failure complicating type A nonfulminant viral hepatitis. A case presentation and review of the literature. J Clin Gastroenterol 1992; 14:160–162.
Nachbaur K, Konig P, Rumpelt HJ, Schobel B, Lhotta K, Vogel W. Acute renal failure complicating non-fulminant hepatitis A. Clin Nephrol 1996; 45:398–400.
Cacoub P, Saadoun D, Bourliere M, et al. Hepatitis B virus genotypes and extrahepatic manifestations. J Hepatol 2005; 43:764–770.
Duffy J, Lidsky MD, Sharp JT, et al Polyarthritis, polyarteritis and hepatitis B. Medicine (Balt) 1976; 55:19–37.
Han SH. Extrahepatic manifestations of chronic hepatitis B. Clin Liver Dis 2004; 8:403–418.
Alpert E, Isselbacher KJ, Schur PH. The pathogenesis of arthritis associated with viral hepatitis. Complement-component studies. N Engl J Med 1971; 285:185–189.
Wands JR, Alpert E, Isselbacher KJ. Arthritis associated with chronic active hepatitis: complement activation and characterization of circulating immune complexes. Gastroenterology 1975; 69:1286–1291.
Drueke T, Barbanel C, Jungers P, et al. Hepatitis B antigen-associated periarteritis nodosa in patients undergoing long-term hemodialysis. Am J Med 1980; 68:86–90.
Hurlburt KJ, McMahon BJ, Deubner H, Hsu-Trawinski B, Williams JL, Kowdley KV. Prevalence of autoimmune liver disease in Alaska Natives. Am J Gastroenterol 2002; 97:2402–2407.
Chan G, Kowdley KV. Extrahepatic manifestations of chronic viral hepatitis. Compr Ther 1995; 21:200–205.
Guillevin L, Lhote F, Cohen P, et al. Polyarteritis nodosa related to hepatitis B virus. A prospective study with long-term observation of 41 patients. Medicine (Balt) 1995; 74:238–253.
Guillevin L, Visser H, Noel LH, et al. Antineutrophil cytoplasm antibodies in systemic polyarteritis nodosa with and without hepatitis B virus infection and Churg-Strauss syndrome—62 patients. J Rheumatol 1993; 20:1345–1349.
Fye KH, Becker MJ, Theofilopoulos AN, Moutsopoulos H, Feldman JL, Talal N. Immune complexes in hepatitis B antigenassociated periarteritis nodosa. Detection by antibody-dependent cell-mediated cytotoxicity and the Raji cell assay. Am J Med 1977; 62:783–791.
Rogers RB, Smith JG Jr, Chalker DK. Hepatitis and the skin. J Am Acad Dermatol 1982; 7:552–554.
Trepo C, Guillevin L. Polyarteritis nodosa and extrahepatic manifestations of HBV infection: the case against autoimmune intervention in pathogenesis. J Autoimmun 2001; 16:269–274.
Bhimma R, Coovadia HM. Hepatitis B virus-associated nephropathy. Am J Nephrol 2004; 24:198–211.
McElgunn PS. Dermatologic manifestations of hepatitis B virus infection. J Am Acad Dermatol 1983; 8:539–548.
Katakura Y, Yotsuyanagi H, Hashizume K, et al. Pancreatic involvement in chronic viral hepatitis. World J Gastroenterol 2005; 11:3508–3513.
Brown KE, Tisdale J, Barrett AJ, Dunbar CE, Young NS. Hepatitisassociated aplastic anemia. N Engl J Med 1997; 336:1059–1064.
Cacoub P, Renou C, Rosenthal E, et al. Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d’Etude et de Recherche en Medecine Interne et Maladies Infectieuses sur le Virus de l’Hepatite C. Medicine (Balt) 2000; 79:47–56.
Bandi L. Renal manifestations of hepatitis C virus infection. Extrahepatic complications often are silent— and thus overlooked. Postgrad Med 2003; 113:73–76, 86.
Johnson RJ, Gretch DR, Yamabe H, et al. Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 1993; 328:465–470.
Clifford BD, Donahue D, Smith S, et al. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C. Hepatology 1995; 231:613–619.
Rasul I, Shepherd FA, Kamel-Reid S, Krajden M, Pantalony D, Heathcote EJ. Detection of occult low-grade b-cell non-Hodgkin’s lymphoma in patients with chronic hepatitis C infection and mixed cryoglobulinemia. Hepatology 1999; 29:543–547.
Gisbert JP, Garcia-Buey L, Pajares JM, Moreno-Otero R. Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma: systematic review and meta-analysis. Gastroenterology 2003; 125:1723–1732.
Moorman J, Saad M, Kosseifi S, Krishnaswamy G. Hepatitis C virus and the lung: implications for therapy. Chest 2005; 128: 2882–2892.
Bahtiyar G, Shin JJ, Aytaman A, Sowers JR, McFarlane SI. Association of diabetes and hepatitis C infection: epidemiologic evidence and pathophysiologic insights. Curr Diab Rep 2004; 4: 194–198.
Fattovich G, Giustina G, Favarato S, Ruol A. A survey of adverse events in 11,241 patients with chronic viral hepatitis treated with alfa interferon. J Hepatol 1996; 24:38–47.
Simsek H, Telatar H. Successful treatment of hepatitis B virusassociated polyarteritis nodosa by interferon alpha alone. J Clin Gastroenterol 1995; 20:263–265.
Guillevin L, Lhote F, Sauvaget F, et al. Treatment of polyarteritis nodosa related to hepatitis B virus with interferon-alpha and plasma exchanges. Ann Rheum Dis 1994; 53:334–337.
Czaja AJ, Kruger M, Santrach PJ, Breanndan Moore S, Manns MP. Genetic distinctions between types 1 and 2 autoimmune hepatitis. Am. J. Gastroenterol. 1997; 92:2197–2200.
Gan SI, Devlin SM, Scott-Douglas NW, Burak KW. Lamivudine for the treatment of membranous glomerulopathy secondary to chronic hepatitis B infection. Can J Gastroenterol 2005; 19:625–629.
Durand JM, Cacoub P, Lunel-Fabiani F, et al. Ribavirin in hepatitis C related cryoglobulinemia. J Rheumatol 1998; 25:1115–1117.
Kim JD, Sherker AH. Antiviral therapy: role in the management of extrahepatic diseases. Gastroenterol Clin North Am 2004; 33: 693–708, xi.
Hermine O, Lefrere F, Bronowicki JP, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Engl J Med 2002; 347:89–94.
Alric L, Plaisier E, Thebault S, et al. Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN. Am J Kidney Dis 2004; 43:617–623.
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© 2007 Humana Press Inc., Totowa, NJ
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Pischke, S., Vogel, A., Jaeckel, E., Manns, M.P. (2007). Immunopathogenesis of Extrahepatic Manifestations in HAV, HBV, and HCV Infections. In: Gershwin, M.E., Vierling, J.M., Manns, M.P. (eds) Liver Immunology. Humana Press. https://doi.org/10.1007/978-1-59745-518-3_17
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DOI: https://doi.org/10.1007/978-1-59745-518-3_17
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