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The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis

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Liver Immunology

Abstract

Hepatic fibrosis represents a ubiquitous response of the liver to acute or chronic injury. Tremendous progress in understanding the pathophysiology of this wound-healing response has led to realistic expectations for treating fibrosis in patients with chronic liver disease owing to either viral hepatitis or metabolic or autoimmune diseases, among others. There has been continued clarification of the cellular source of extracellular matrix (ECM) in hepatic fibrosis, major advances in understanding signaling and transcriptional events, and exciting insights into the biology of fibrosis progression and resolution (see refs. 1–4 and references therein for more general reviews).

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Authors and Affiliations

  1. Division of Digestive Diseases, Yale University School of Medicine, New Haven, CT

    Wajahat Z. Mehal MD, DPHIL

  2. Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY

    Scott L. Friedman MD

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  1. Wajahat Z. Mehal MD, DPHIL
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  2. Scott L. Friedman MD
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Editors and Affiliations

  1. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA

    M. Eric Gershwin MD, FACP

  2. Departments of Medicine and Surgery Baylor Liver Health, Baylor College of Medicine, Houston, TX

    John M. Vierling MD, FACP

  3. Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany

    Michael P. Manns MD

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Mehal, W.Z., Friedman, S.L. (2007). The Role of Inflammation and Immunity in the Pathogenesis of Liver Fibrosis. In: Gershwin, M.E., Vierling, J.M., Manns, M.P. (eds) Liver Immunology. Humana Press. https://doi.org/10.1007/978-1-59745-518-3_10

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