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Postpartum Thyroiditis

  • Chapter
Autoimmune Diseases in Endocrinology

Part of the book series: Contemporary Endocrinology ((COE))

Summary

Postpartum thyroiditis (PPT) occurs in 5–9% of women and is strongly associated with positive thyroid peroxidase antibodies (TPOAb positive) as determined around 14 weeks gestation. Postpartum thyroid dysfunction (PPTD) occurs in 50% of TPOAb-positive women (measured at 14 weeks gestation) and presents as transient hyperthyroidism (median onset 13 weeks postpartum) followed by transient hypothyroidism (median onset 19 weeks postpartum); the latter will develop into permanent hypothyroidism in up to 30% of women. Women who then remain euthyroid after transient thyroid dysfunction have a 75% chance of PPTD in a subsequent pregnancy and a 50% risk of permanent hypothyroidism after 7 years. The hyperthyroid phase is relatively asymptomatic, but the hypothyroid phase may be very clinically evident and require levothyroxine treatment.

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Authors
  1. John H. Lazarus MA,MD,FRCP,FACE,FRCOG
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  2. L.D. K.E. Premawardhana MBBS,FRCP
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Anthony P. Weetman MD,DSc

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Lazarus, J.H., Premawardhana, L.K. (2007). Postpartum Thyroiditis. In: Weetman, A.P. (eds) Autoimmune Diseases in Endocrinology. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-517-6_8

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