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When Puberty is Precocious pp 267–284Cite as

Congenital Adrenal Hyperplasia

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Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Congenital adrenal hyperplasia, a family of autosomal recessive diseases of cortisol synthesis, is commonly associated with disordered puberty. Perturbations of pubertal onset and progress are determined by which hormones are overproduced and which are deficient. There may be precocious pubarche or puberty, sexual infantilism and failure to initiate or complete pubertal development, menstrual irregularity, hirsutism and infertility. In addition to glucocorticoid treatment to replace the deficient cortisol and mineralocorticoid if salt-wasting is present, treatment may include sex steroids, LHRH agonists, aromatase inhibitors and genital surgery.

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Authors
  1. Lenore S. Levine MD
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  2. Sharon E. Oberfield MD
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  3. Lauren Antler BA
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Editor information

Editors and Affiliations

  1. Departments of Pediatrics and Cellular and Integrative Physiology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN

    Ora H. Pescovitz MD

  2. Section of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA

    Emily C. Walvoord MD

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© 2007 Humana Press Inc.

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Levine, L.S., Oberfield, S.E., Antler, L. (2007). Congenital Adrenal Hyperplasia. In: Pescovitz, O.H., Walvoord, E.C. (eds) When Puberty is Precocious. Contemporary Endocrinology. Humana Press. https://doi.org/10.1007/978-1-59745-499-5_12

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  • DOI: https://doi.org/10.1007/978-1-59745-499-5_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-742-6

  • Online ISBN: 978-1-59745-499-5

  • eBook Packages: MedicineMedicine (R0)

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