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In Vivo Models of Allogeneic Hematopoietic Stem Cell Transplantation

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Book cover Allogeneic Stem Cell Transplantation

Part of the book series: Contemporary Hematology ((CH))

Abstract

Animal models have been vital to the development of allogeneic hematopoietic stem cell transplantation (AlloHSCT) as well as our understanding of its biology. Rodent models led the way in the demonstration of the whole body radiotherapy for effective anti-tumor responses [1] and the ability to rescue mice from high dose radiation with a transfusion of bone marrow cells [2, 3] in the early 1950s. However, the ability to promote prolonged tumor-free survival in mice using allogeneic bone marrow transplantation after myeloablative doses of radiation was offset by the recognition that allogeneic bone marrow transplant (BMT) could result in a lethal “secondary” disease of wasting, diarrhea and skin lesions [4] now known as graft-versus host disease. Interestingly, graft-versus-tumor (GVT) activity was also recognized in studies during this time period. [5, 6].

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Acknowledgments.

The work from the authors’ laboratories was supported by NIH R01 CA93527, R01 HL089905, R01 CA102282 and R01 AG022661.

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  1. Department of Dermatology, University of California, Davis Sacramento, CA, 95817, USA

    Lisbeth A. Welniak & William J. Murphy

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  1. Lisbeth A. Welniak
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  2. William J. Murphy
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  1. University Hospitals Case Medical Center, Cleveland, OH, USA

    Hillard M. Lazarus

  2. Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin

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Welniak, L.A., Murphy, W.J. (2010). In Vivo Models of Allogeneic Hematopoietic Stem Cell Transplantation. In: Lazarus, H.M., Laughlin, M.J. (eds) Allogeneic Stem Cell Transplantation. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-478-0_44

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