Abstract
Invasive fungal infections (IFI) are important causes of infectious morbidity and mortality after allogeneic stem cell transplant (ASCT). Candida, Aspergillus, and Pneumocystis are the chief fungal pathogens and historically have accounted for most of the IFIs. In recent years, Zygomycosis and several other fungal pathogens such as Fusarium and Scedosporium have grown in frequency. A bimodal distribution in the time of occurrence of IFIs has been noted: an early peak prior to engraftment due mostly to Candida and a later peak during the second and third months due mostly to Aspergillus. Risk for Pneumocystis is mostly during the second to the sixth month. In recent years, the second peak has extended to later periods and late infections by IFI have been noted 6 months or later. Over the past two decades, a climb in the rate of Aspergillosis has been noted in many centers.
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Wingard, J.R. (2010). Fungal Infections. In: Lazarus, H.M., Laughlin, M.J. (eds) Allogeneic Stem Cell Transplantation. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-478-0_30
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