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Therapeutic Potential of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation

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Allogeneic Stem Cell Transplantation

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Mesenchymal Stem Cells (MSCs) are non-hematopoietic multipotent cells residing in the stroma of the bone marrow that are capable of differentiating into both mesenchymal and non-mesenchymal lineages [1]. In fact, in addition to bone, cartilage, fat, and myoblasts, it has been demonstrated that MSCs are capable of differentiating into neurons and astrocytes in vitro and in vivo [2, 3]. Multipotent Adult Progenitor Cells (MAPCs) are also multipotent cells that can be isolated from the bone marrow. Although these cells share some features with MSCs, they differ from MSCs at several levels; MAPCs are expanded at low densities under low oxygen tension; they are CD90+, CD49C+, CD10+, CD45− and class II HLA−; they have active telomerase, are genetically stable and exhibit greater neurologic and hematopoietic potential than MSCs [4].

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Authors and Affiliations

  1. Case Comprehensive Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA

    Luis A. Solchaga & Hillard M. Lazarus

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  1. Luis A. Solchaga
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  2. Hillard M. Lazarus
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  1. University Hospitals Case Medical Center, Cleveland, OH, USA

    Hillard M. Lazarus

  2. Case Western Reserve University, Cleveland, OH, USA

    Mary J. Laughlin

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Solchaga, L.A., Lazarus, H.M. (2010). Therapeutic Potential of Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation. In: Lazarus, H.M., Laughlin, M.J. (eds) Allogeneic Stem Cell Transplantation. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-59745-478-0_27

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  • DOI: https://doi.org/10.1007/978-1-59745-478-0_27

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