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Women and Coronary Heart Disease

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Women’s Health in Clinical Practice

Part of the book series: Current Clinical Practice ((CCP))

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Abstract

Cardiovascular disease (CVD), encompassing both coronary heart disease (CHD) and cerebrovascular disease, is a major health burden worldwide in men and women. Although historically considered a “man’s disease,” this myth is quickly fading and for good reason.

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References

  1. Bonita R, Wilson E, Fodor G, et al. The First International Conference on Women, Heart Disease and Stroke: Science and Policy in Action. Victoria, British Columbia, Canada, May 7–10, 2000. (Accessed March 17, 2005, at http://www.medscape.com/viewpro-gram/897_pnt.)

    Google Scholar 

  2. American Heart Association. Heart Disease and Stroke Statistics-2005 Update. American Heart Association, Dallas, 2005.

    Google Scholar 

  3. Wenger NK, You’ve come a long way, baby-cardiovascular health and disease in women-problems and prospects. Circulation 2004;109:558–560.

    Article  PubMed  Google Scholar 

  4. Thomas JL, Braus PA. Coronary artery disease in women-a historical perspective. Arch Intern Med 1998;158:333–337.

    Article  CAS  PubMed  Google Scholar 

  5. Winkleby MA, Kraemer HC, Ahn DK, Varady AN. Ethnic and socioeconomic differences in CVD risk factors-findings for women from the third national health and nutrition examination survey, 1988–1994. JAMA 1998;280:356–362.

    Article  CAS  PubMed  Google Scholar 

  6. Casper ML, Barnett E, Halverson JA, et al. Women and Heart Disease: An Atlas of Racial and Ethnic Disparities in Mortality, 2nd ed. Office for Social Environment and Health Research, West Virginia University, Morgantown, WV, 2000.

    Google Scholar 

  7. Sorlie PD, Rogot E, Johnson NJ. Validity of demographic characteristics on the death certificate. Epidemiology 1992;3:181–184.

    Article  CAS  PubMed  Google Scholar 

  8. Williams DR, Collins C. U.S. socioeconomic and racial differences in health: patterns and explanations. Annu Rev Sociol 1995;21:349–386.

    Article  Google Scholar 

  9. D’Agostino RB, Grundy S, Sullivan LM, Wilson P. Validation of the Framingham coronary heart disease predictions scores: results of a multiple ethnic groups investigation. JAMA 2001;286(2):180–187.

    Article  PubMed  Google Scholar 

  10. National Cholesterol Education Program. Third Report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). NIH Pub. No. 02-5215. National Heart, Lung, and Blood Institute, Bethesda, MD, 2002.

    Google Scholar 

  11. American Diabetes Association. Position paper: diagnosis and classification of diabetes mellitus. Diabetes Care 2005;28:S37–S42.

    Article  Google Scholar 

  12. Blake GJ, Pradhan AD, Manson JE, et al. Hemoglobin A1C level and future cardiovascular events among women. Arch Intern Med 2004;164:757–761.

    Article  CAS  PubMed  Google Scholar 

  13. Mosca L, Appel LJ, Benjamin EJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women. Circulation 2004;109:672–693.

    Article  PubMed  Google Scholar 

  14. Calles-Escandon J, Garcia-Rubi E, Mirza S, Mortensen A. Type 2 diabetes: one disease, multiple cardiovascular risk factors. Coron Artery Dis 1999;10:23–30.

    Article  CAS  PubMed  Google Scholar 

  15. Barrett-Connor E, Giardina EG, Gitt AK, Gudat U, Steinberg HO, Tschoepe D. Women and heart disease: the role of diabetes and hyperglycemia. Arch Intern Med 2004;164:934–942.

    Article  PubMed  Google Scholar 

  16. Kanaya AM, Grady D, Barrett-Connor E. Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus. Arch Intern Med 2002;162:1737–1745.

    Article  PubMed  Google Scholar 

  17. Sowers JR. Diabetes mellitus and cardiovascular disease in women. Arch Intern Med 1998;158:617–621.

    Article  CAS  PubMed  Google Scholar 

  18. U.S. Preventive Services Task Force. Screening for diabetes mellitus, adult type 2. Release date: February 2003 (Accessed May 2, 2005, at http://www.ahrq.gov/clinic/uspstf/usps-diab.htm.).

    Google Scholar 

  19. American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2005;28(1):S4–S36.

    Article  Google Scholar 

  20. Ninomiya JK, L’Italien G, Criqui MH, Whyte JL, Gamst A, Chen RS. Association of the metabolic syndrome with history of myocardial infarction and stroke in the third national health and nutrition examination survey. Circulation 2004;109:42–46.

    Article  PubMed  Google Scholar 

  21. Kip KE, Marroquin OC, Kelley DE, et al. Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the women’s ischemia syndrome evaluation (WISE) study. Circulation 2004;109:706–713.

    Article  PubMed  Google Scholar 

  22. Marroquin OC, Kip KE, Kelley DE, et al. Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the women’s ischemia syndrome evaluation. Circulation 2004;109:714–721.

    Article  CAS  PubMed  Google Scholar 

  23. Chobanian AV, Bakris GL, Black HR, et al. for the National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA 2003;289:2560–2572.

    Article  CAS  PubMed  Google Scholar 

  24. Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population: results from the third national health and nutrition examination survey, 1988–1991. Hypertension 1995;25:305–313.

    CAS  PubMed  Google Scholar 

  25. Gillum RF. Epidemiology of hypertension in African American women. Am Heart J 1996;131:385–395.

    Article  CAS  PubMed  Google Scholar 

  26. Furberg CD, Wright JT, Davis BR, et al. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002;288:2981–2997.

    Article  CAS  Google Scholar 

  27. Mosca L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E. Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Circulation 1997;96:2468–2482.

    CAS  PubMed  Google Scholar 

  28. Grant AO, Jacobs AK, Clancy C. Cardiovascular disease in women-are there solutions? Circulation 2004;109:561.

    Article  PubMed  Google Scholar 

  29. Walsh JM, Pignone M. Drug treatment of hyperlipidemia in women. JAMA 2004;291:2243–2252.

    Article  CAS  PubMed  Google Scholar 

  30. Grundy SM, Cleeman JI, Merz NB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004;110(6):763.

    Article  Google Scholar 

  31. Heart Protection Study Collaborative Group. MRC/BHF Heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebocontrolled trial. Lancet 2002;360:7–22.

    Article  Google Scholar 

  32. Amsterdam EA. At the intersection of cardiology and primary care. Patient Care 2005;46-57.

    Google Scholar 

  33. Orth-Gomer K, Mittleman MA, Schenck-Gustafsson K, Wamala SP, Eriksson M, Belkic K. Lipoprotein(a) as a determinant of coronary heart disease in young women. Circulation 1997;95:329–334.

    CAS  PubMed  Google Scholar 

  34. 2005 Dietary Guidelines Advisory Committee Report. Dietary Guidelines for Americans 2005: U.S. Department of Health and Human Services, U.S. Department of Agriculture (last accessed May 2, 2005, at http://www.health.gov/dietaryguidelines).

    Google Scholar 

  35. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 2000;343:16–22.

    Article  CAS  PubMed  Google Scholar 

  36. Fung TT, Willett WC, Stampfer MJ, Manson JE, Hu FB. Dietary patterns and the risk of coronary heart disease in women. Arch Intern Med 2001;161:1857–1862.

    Article  CAS  PubMed  Google Scholar 

  37. Iso H, Stampfer MJ, Manson JE, et al. Prospective study of fat and protein intake and risk of intraparenchymal hemorrhage in women. Circulation 2001;103:856–863.

    CAS  PubMed  Google Scholar 

  38. Ridker PM, Manson JE, Buring JE, Shih J, Matias M, Hennekens CH. Homocysteine and risk of cardiovascular disease among postmenopausal women. JAMA 1999;281:1817–1821.

    Article  CAS  PubMed  Google Scholar 

  39. Zilberstein DE, Bengtsson C, Björkelung C, et al. Serum homocysteine in relation to mortality and morbidity from coronary heart disease: a 24-year follow-up of the population study of women in Gothenburg. Circulation 2004;109:601–606.

    Article  CAS  Google Scholar 

  40. Rimm EB, Willett WC, Hu FB, et al. Folate and Vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 1998;279:359–364.

    Article  CAS  PubMed  Google Scholar 

  41. Knekt P, Alfthan G, Aromaa A, et al. Homocysteine and major coronary events: a prospective population study amongst women. J Int Med 2001;249:461–465.

    Article  CAS  Google Scholar 

  42. Rosenberg L, Palmer JR, Shapiro S. Decline in the risk of myocardial infarction among women who stop smoking. N Engl J Med 1990;322:213–217.

    Article  CAS  PubMed  Google Scholar 

  43. Gulati M, Pandey DK, Arnsdorf MF, et al. Exercise capacity and the risk of death in women:the St. James women take heart project. Circulation 2003;108:1554–1559.

    Article  PubMed  Google Scholar 

  44. Manson JE, Greenland P, LaCroix AZ, et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002;347:716–725.

    Article  PubMed  Google Scholar 

  45. Lee IM, Rexrode KM, Cook NR, Manson JE, Buring JE. Physical activity and coronary heart disease in women: is “no pain, no gain” passé? JAMA 2001;285:1447–1454.

    Article  CAS  PubMed  Google Scholar 

  46. Manson JE, Hu FB, Rich-Edwards JW, et al. A prospective study of walking as compared with vigorous exercise in the prevention of coronary heart disease in women. N Engl J Med 1999;341:650–658.

    Article  CAS  PubMed  Google Scholar 

  47. Fuchs CS, Stampfer MJ, Colditz GA, et al. Alcohol consumption and mortality among women. N Engl J Med 1995;332:1245–1250.

    Article  CAS  PubMed  Google Scholar 

  48. Solomon CG, Hu FB, Stampfer MJ, et al. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation 2000;102:494–499.

    CAS  PubMed  Google Scholar 

  49. Janszky I, Ericson M, Blom M, et al. Wine drinking is associated with increased heart rate variability in women with coronary heart disease. Heart 2005;91:314–318.

    Article  CAS  PubMed  Google Scholar 

  50. Gaziano JM, Buring JE, Breslow JL, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med 1993;329:1829–1834.

    Article  CAS  PubMed  Google Scholar 

  51. Renaud SC, Beswick AD, Fehily AM, Sharp DS, Elwood PC. Alcohol and platelet aggregation: the Caerphilly prospective heart disease study. Am J Clin Nut 1992;55:1012–1017.

    CAS  Google Scholar 

  52. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836–843.

    Article  CAS  PubMed  Google Scholar 

  53. Davison S, Davis SR. New markers for cardiovascular disease risk in women: impact of endogenous estrogen status and exogenous postmenopausal hormone therapy. J Clin Endo Metab 2003;88:2470–2478.

    Article  CAS  Google Scholar 

  54. Rifai N, Buring JE, Lee IM, Manson JE, Ridker PM. Is C-reactive protein specific for vascular disease in women? Ann Intern Med 2002;136:529–533.

    CAS  PubMed  Google Scholar 

  55. Margolis KL, Manson JE, Greenland P, et al. Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the women’s health initiative observational study. Arch Intern Med 2005;165:500–508.

    Article  PubMed  Google Scholar 

  56. Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004;364:937–952.

    Article  PubMed  Google Scholar 

  57. Barrett-Connor E. An epidemiologist looks at hormones and heart disease in women. J Clin Endo Metab 2003;88:4031–4042.

    Article  CAS  Google Scholar 

  58. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605–613.

    Article  CAS  PubMed  Google Scholar 

  59. Manson JE, Hsia J, Johnson KC, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003;349:523–534.

    Article  CAS  PubMed  Google Scholar 

  60. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–333.

    Article  CAS  PubMed  Google Scholar 

  61. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA 2004;291:1701–1712.

    Article  CAS  PubMed  Google Scholar 

  62. Goldberg RJ, O’Donnell C, Yarzebski J, Bigelow C, Savageau J, Gore JM. Sex differences in symptom presentation associated with acute myocardial infarction: a population-based perspective. Am Heart J 1998;136:189–195.

    Article  CAS  PubMed  Google Scholar 

  63. McSweeney JC, Cody M, O’Sullivan P, Elberson K, Moser DK, Garvin BJ. Women’s early warning symptoms of acute myocardial infarction. Circulation 2003;108:2619–2623.

    Article  PubMed  Google Scholar 

  64. Lehmann JB, Wehner PS, Lehmann CU, Savory LM. Gender bias in the evaluation of chest pain in the emergency department. Amer J Card 1996;77:641–644.

    Article  CAS  Google Scholar 

  65. Massey CV, Hupp CH, Kreisberg MS, Burpo SS, Hoff CJ, Alpert MA. Race affects time to presentation, but not diagnostic evaluation of women with suspected coronary artery disease. JACC (Abstract). February 1995;982-117:267A–268A.

    Google Scholar 

  66. Wiviott SD, Cannon CP, Morrow DA, et al. Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction. Circulation 2004;109:580–586.

    Article  CAS  PubMed  Google Scholar 

  67. Kwok Y, Kim C, Grady D, Segal M, Redberg R. Meta-analysis of exercise testing to detect coronary artery disease in women. Am J Cardiol 1999;83:660–666.

    Article  CAS  PubMed  Google Scholar 

  68. Marwick TH, Anderson T, Williams MJ, et al. Exercise echocardiography is an accurate and cost-efficient technique for detection of coronary artery disease in women. J Am Coll Card 1995;26:335–341.

    Article  CAS  Google Scholar 

  69. Sketch MH, Mohiuddin SM, Lynch JD, Zencka AE, Runco V. Significant sex differences in the correlation of electrocardiographic exercise testing and coronary arteriograms. Am J Card 1975;36:169–173.

    Article  CAS  PubMed  Google Scholar 

  70. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 2004;291:210–215.

    Article  CAS  PubMed  Google Scholar 

  71. O’Rourke RA, Brundage BH, Froelicher VF, et al. American College of Cardiology/ American Heart Association expert consensus document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease. J Am Coll Cardiol 2000;36:326–340.

    Article  PubMed  Google Scholar 

  72. Bugiardini R, Merz CN. Angina with “normal” coronary arteries: a changing philosophy. JAMA 2005;293:477–484.

    Article  CAS  PubMed  Google Scholar 

  73. Reis SE, Holubkov R, Conrad-Smith AJ, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J 2001;141:735–741.

    Article  CAS  PubMed  Google Scholar 

  74. Shaw LJ, Gibbons RJ, McCallister B, et al. Gender differences in extent and seventy of coronary disease in the ACC-National Cardiovascular Data Registry (abstract). J Am Coll Cardiol 2002;39:321A.

    Article  Google Scholar 

  75. Johnson BD, Shaw LJ, Buchthal SD, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease. Circulation 2004;109:2993–2999.

    Article  PubMed  Google Scholar 

  76. Gurevitz O, Jonas M, Boyko V, Rabinowitz B, Reicher-Reiss H. Clinical profile and long-term prognosis of women <50 years of age referred for coronary angiography for evaluation of chest pain. Am J Cardiol 2000;85:806–809.

    Article  CAS  PubMed  Google Scholar 

  77. Steingart RM, Packer M, Hamm P, et al. Sex differences in the management of coronary artery disease. N Engl J Med 1991;325:226–230.

    CAS  PubMed  Google Scholar 

  78. Shaw LJ, Miller DD, Romeis JC, Kargl D, Younis LT, Chaitman BR. Gender differences in the noninvasive evaluation and management of patients with suspected coronary artery disease. Ann Int Med 1994;120:559–566.

    CAS  PubMed  Google Scholar 

  79. Hachamovitch R, Berman DS, Kiat H, et al. Gender-related differences in clinical management after exercise nuclear testing. J Am Coll Cardiol 1995;26:1457–1464.

    Article  CAS  PubMed  Google Scholar 

  80. Gottlieb S, Harpaz D, Shotan A, et al. Sex differences in management and outcome after acute myocardial infarction in the 1990s: a prospective observational community-based study. Circulation 2000;102:2484–2490.

    CAS  PubMed  Google Scholar 

  81. Ghali WA, Faris PD, Galbraith PD, et al. Sex differences in access to coronary revascularization after cardiac catheterization: importance of detailed clinical data. Ann Intern Med 2002;136:723–732.

    PubMed  Google Scholar 

  82. Scirica BM, Moliterno DJ, Every NR, et al. Differences between men and women in the management of unstable angina pectoris (the GUARANTEE registry), Am J Cardiol 1999;84:1145–1150.

    Article  CAS  PubMed  Google Scholar 

  83. Vaccarino V, Parsons L, Every NR, et al. Sex-based differences in early mortality after myocardial infarction. N Engl J Med 1999;341:217–225.

    Article  CAS  PubMed  Google Scholar 

  84. Vaccarino V, Horwitz RI, Meehan TP, Petrillo MK, Radford MJ, Krumholz HM. Sex differences in mortality after myocardial infarction: evidence for a sex-age interaction. Arch Intern Med 1998;158:2054–2062.

    Article  CAS  PubMed  Google Scholar 

  85. MacIntyre K, Stewart S, Capewell S, et al. Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardiol 2001;38:729–735.

    Article  CAS  PubMed  Google Scholar 

  86. Malacrida R, Genoni M, Maggioni AP, et al. A comparison of the early outcome of acute myocardial infarction in women and men. N Engl J Med 1998;338:8–14.

    Article  CAS  PubMed  Google Scholar 

  87. Chang WC, Kaul P, Westerhout CM, et al. Impact of sex on long-term mortality from acute myocardial infarction vs unstable angina. Arch Int Med 2003;163:2476–2484.

    Article  Google Scholar 

  88. Greenland P, Knoll MD, Stamler J, et al. Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA 2003;290:891–897.

    Article  PubMed  Google Scholar 

  89. Khot UN, Khot MB. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003;290:898–904.

    Article  PubMed  Google Scholar 

  90. Canto JG, Iskandrian AE. Major risk factors for cardiovascular disease-debunking the “only 50%” myth. JAMA 2003;290:947–949.

    Article  PubMed  Google Scholar 

  91. Mosca L, Ferris A, Fabunmi R, Robertson RM. Tracking women’s awareness of heart disease: an American Heart Association national study. Circulation 2004;109:573–579.

    Article  PubMed  Google Scholar 

  92. National Women’s Law Center, University of Pennsylvania School of Medicine, Oregon Health & Science University. Making the grade on women’s health: a national and state-by-state report card. 2001. (Available at http://www.nwlc.org/pdf/2001ReportCardChapter4.pdf).

    Google Scholar 

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Authors and Affiliations

  1. Wyeth Pharmaceuticals, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA

    Susan Mather MD

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  1. Susan Mather MD
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Editors and Affiliations

  1. Family Medicine Residency Program, Abington Memorial Hospital, Abington, PA

    Amy L. Clouse MD

  2. Department of Medicine, Drexel University College of Medicine, Philadelphia, PA

    Katherine Sherif MD

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Mather, S. (2008). Women and Coronary Heart Disease. In: Clouse, A.L., Sherif, K. (eds) Women’s Health in Clinical Practice. Current Clinical Practice. Humana Press. https://doi.org/10.1007/978-1-59745-469-8_5

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  • DOI: https://doi.org/10.1007/978-1-59745-469-8_5

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