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Alzheimer’s Dementia

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Iron Deficiency and Overload

Part of the book series: Nutrition and Health ((NH))

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Summary

• The disability caused by Alzheimer’s disease (AD) is increasing worldwide with 4.6 million newly diagnosed patients every year.

• Age-related oxidative stress appears to be an important contributor to the amyloid pathology and neuronal degeneration of AD.

• Iron homeostasis is altered in AD patients.

• Iron promotes the formation of amyloid plaques and neurofibrillary tangles, which are the hallmarks of the disease.

• Iron also causes synaptic dysfunction by altering cell membrane integrity and impairing the function of membrane-bound proteins.

• Future treatments for AD may include dietary modifications and drugs that reduce the amount of toxic free iron, or that protect cells against iron toxicity.

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Authors and Affiliations

  1. Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA

    Seema Gulyani PHD (RN) & Mark P. Mattson PHD

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  1. Seema Gulyani PHD
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  1. Dept. Psychology, Bar-Ilan University, Ramat Gan, 52900, Israel

    Shlomo Yehuda

  2. Dept. Psychology, Boston University, Cummington St. 64, Boston, 02215-2407, USA

    David I. Mostofsky

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Gulyani, S., Mattson, M.P. (2009). Alzheimer’s Dementia. In: Yehuda, S., Mostofsky, D. (eds) Iron Deficiency and Overload. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-462-9_14

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