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The Molecular Basis of Human Cancer pp 355–361Cite as

Retinoblastoma: Clinical and Molecular Perspectives

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Abstract

Retinoblastoma is a rare eye cancer that has been fundamental to the understanding of tumorigenesis. The RB gene was the first tumor suppressor gene to be discovered, and the Rb protein is targeted for inactivation in the vast majority of human cancers. This chapter reviews the clinical features of retinoblastoma and highlights the insights into molecular oncology that have resulted from study of the Rb tumor suppressor pathway.

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Authors and Affiliations

  1. Ocular Oncology Service, Bascom Palmer Eye Institute and Sylvester Comprehensive Cancer Center, University of MIami Miller School of Medicine, 900 NW 17th Street, Miami, FL, 33136, USA

    J. William Harbour M.D.

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  1. J. William Harbour M.D.
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Correspondence to J. William Harbour M.D. .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    William B. Coleman

  2. Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, Hanover, New Hampshire, USA

    Gregory J. Tsongalis

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Harbour, J.W. (2017). Retinoblastoma: Clinical and Molecular Perspectives. In: Coleman, W., Tsongalis, G. (eds) The Molecular Basis of Human Cancer. Humana Press, New York, NY. https://doi.org/10.1007/978-1-59745-458-2_23

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  • DOI: https://doi.org/10.1007/978-1-59745-458-2_23

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