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Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas

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The Molecular Basis of Human Cancer

Abstract

Unlike chemical carcinogens that can interact with DNA, and be metabolized or detoxified by cells, erionite and asbestos fibers are poorly soluble, naturally occurring fibers that may persist in the lung or pleura for decades after inhalation. Thus, they are commonly referred to as physical carcinogens. Historically, their mechanisms of action have been compared to foreign body carcinogenesis in which plastics or other materials are injected under the skin of rodents and produce sarcomas. In reality, the complex mechanisms of fiber carcinogenesis are still unclear despite decades of research.

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Acknowledgements

The authors appreciate the assistance of Maximilian MacPherson in the preparation of figures and the diligence of Jennifer Díaz in manuscript preparation. Research in Dr. Mossman’s laboratory has been funded by grants from the NIH, ACS, and EPA.

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  1. Department of Pathology, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, 05405-0068, USA

    Mutlay Sayan M.D. & Brooke T. Mossman Ph.D.

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  1. Mutlay Sayan M.D.
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  2. Brooke T. Mossman Ph.D.
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Correspondence to Brooke T. Mossman Ph.D. .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    William B. Coleman

  2. Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, Hanover, New Hampshire, USA

    Gregory J. Tsongalis

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Sayan, M., Mossman, B.T. (2017). Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas. In: Coleman, W., Tsongalis, G. (eds) The Molecular Basis of Human Cancer. Humana Press, New York, NY. https://doi.org/10.1007/978-1-59745-458-2_18

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